Peripheral Blood Films Flashcards
Acanthocytes
RBCs show spicules
abetolipoproteinaemia, liver disease, hyposplenism
Burr cells
Irreguraly shaped cells
Uraemia, GI bleed, stomach carcinoma
Heinz Bodies
Inclusions w/n RBCs (denatured Hb)
G6PD dcy, chronic liver disease
Howell-Jolly bodies
Purple spots in RBCs
Post-splenectomy/hyposplenism (e.g. SCA), megaloblastic anaemia, hereditary sphrerocytosis
Leucoerythroblastic
nucleated RBCs and primitive WBCs
marrow inflitration
Pelger Huet cells
Hyposegmented neutrophils
Myelogenous leukaemia and myelodysplactic syndrome
Reticulocytes
Immature RBCs
increase in haemolytic anaemia
decrease in aplastic anaemia, chemo
Right shift
Hypermature (hypoersegmented) white cells
Megaloblastic anaemia, uraemia, liver disease
Rouleax formation
Red cells stacked on each other
Chronic IFM, paraproteinaemia, myeloma
Schistocytes
Fragmented RBCs
Microangiopathic anaemia (e.g. DIC, HUS, TTP, pre-eclampsia)
Spherocytes
Sphere-shaped RBCs
Hereditary spherocytosis, AIHA
Target cells
“Bulls-eye” appearance
Liver disease, thalassaemia, hyposplenism, IDA
