Peripheral vascular disease Flashcards

(36 cards)

1
Q

Define peripheral vascular disease

A

Circulatory condition involving reduced blood flow to the limbs due to narrowed blood vessels

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2
Q

What is peripheral vascular disease also known as?

A

Chronic limb arterial insufficiency/ischemia

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3
Q

Give the etiology of peripheral vascular disease

A
Atherosclerosis 
HIV vasculopathy
Popliteal aa entrapment
Mucinous cystic degeneration
Buerger's disease
Abdominal aortic co-arctation
Peripheral emboli
Fibrodysplasia
Pseudoxanthoma elasticum
Persistent sciatic aa
Iliac aa syndrome
Primary arterial tumours
Hypercoaguability
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4
Q

Name risk factors for atherosclerosis

A
Smoking
DM
Hypertension
Hyperlipidemia
Obesity
Elevated homocystein/fibrinogen
Male
>55yo
Family history
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5
Q

What is Leriche syndrome?

A

Clinical syndrome involving

  1. Buttock claudication
  2. Impotence
  3. Decr/absent femoral pulses
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6
Q

Name clinical features of peripheral vascular disease

A
Silent
Intermittent claudication
Absent pulses
Trophic changes
Rest pain
Critical limb ischemia
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7
Q

Name the features of ischemic rest pain

A

> 2w duration
Worse at night
Relieved by leg dependency

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8
Q

Name causes of intermittent claudication

A

PVD
Venous claudication
Neurogenic claudication

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9
Q

Define intermittent claudication

A
  1. Pain, cramps or paresthesia distal to arterial occlusion
  2. Worsens upon exertion completely relieved by rest
  3. Reproducible
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10
Q

How do you differentiate between intermittent claudication, venous claudication and neurogenic claudication?

A
Quality of pain
Onset
Relieved by
Location
Legs affected
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11
Q

Give the characteristics of intermittent claudication

A
Cramping pain
Gradual onset
Relieved by rest
Located at muscle groups
Usually one leg affected
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12
Q

Give the characteristics of venous claudication

A
Aching, heavy pain
Gradual/immediate onset
Relieved by activity
Whole leg
Usually one leg affected
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13
Q

Give the characteristics of neurogenic claudication

A
Pins and needles
Immediate onset
Relieved by sitting down, flexion
Poorly localized
Often both legs affected
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14
Q

Differentiate between ischemic, venous and neuropathic ulcers

A

Pain
Location
Pulses
Appearance

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15
Q

Name the characteristics of ischemic ulcers

A

Painful
Distal foot
Absent foot pulses
Punch out w/ gangrenous base

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16
Q

Name the characteristics of venous ulcers

A

Mild pain unless septic
Medial malleolus
Pulses present
Shallow with granulation tissue at base

17
Q

Name the characteristics of neuropathic ulcers

A

Painless
Located at pressure points
Pulses present
Granulation tissue

18
Q

Define critical limb ischemia

A
  1. Persistent, recurring ischemic rest pain requiring opiate analgesia >2w
  2. Ulceration/gangrene of foot/toes
  3. Ankle systolic <50
  4. Toe systolic <30
19
Q

What do absent femoral pulses indicate?

A

Aorto-iliac disease

20
Q

What do absent popliteal pulses with present femoral pulses indicate?

A

Femoral-popliteal disease

21
Q

What do absent foot pulses with palpable popliteal pulses indicate?

A

Tibio-peroneal disease

22
Q

How can you asses severity of PVD using a measurement?

A

Ankle-to-brachial index

23
Q

Discuss the grading of severity of PVD using ankle-to-brachial index

A

> 0.9 normal
0.8 - 0.9 mild
0.5 - 0.79 moderate
<0.5 severe

24
Q

Name special investigations in PVD

A

Duplex ultrasound
Angiography
Convnitonal angiogram

25
What do duplex ultrasound findings indicate in PVD?
Triphasic flow - normal Biphasic flow - proximal occlusion Monophasic flow - proximal stenosis
26
Which classification is used to assess PVD severity?
Fontaine classification
27
Discuss the Fontaine classification of peripheral vascular disease
Stage 1 asymptomatic Stage 2a intermittent claudication after >200m pain free walking Stage 2b intermittent claudication after <200m pain free walking Stage 3 ischemic rest pain Stage 4 ischemic ulceration/gangrene
28
Name the objectives of management in peripheral vascular disease
``` Pain relief Ulcer healing Limb loss prevention Improve patient function and QOL Prolong survival ```
29
Discuss the management of peripheral vascular disease
Best medical therapy 1. Pharmacology - statins (dyslipidemia) - ACE-Is (hypertension) - metformin (diabetes) - aspirin (all) - PDE inhibitors 2. Lifestyle modification - smoking cessation - exercise Surgery
30
Name indications for surgery in peripheral vascular disease
Disabling claudication | Critical limb ischemia
31
Name types of surgical intervention
Endovascular - PTA and stenting Open - endartectomy - surgical bypass
32
Name types of bypass grafts
Autogenous - vein (long saphenous, short saphenous, superficial femoral) - artery (internal mammary, radial) Biological - human umbilical vein - bovine pericardial - porcine Synthetic - ePTFE (goretex) - dacron
33
Which trial compared open to endovascular surgery and what were the findings
BASIL trial Endovascular = less invasive Open = better long term patency
34
Name complications of surgical revascularisation
Early - hemorrhage - limb ischemia - renal failure - intestinal ischemia Late - graft occlusion - infection - aorto-enteric fistula
35
Which organism is most common in surgical revascularization infection?
Staph epidermidis
36
Discuss PDE inhibitors
Can be given after 3months graded exercise therapy in lifestyle-limiting intermittent claudication Reduces platelet aggregation Causes arterial vasodilation