Pesticides And Rodenticides

Question 1

Mention the role of antidotes in OPC poisoning
How are carbamates different?

Answer 1

1-Atropine antagonizes M but not N effects, may protect from cardiac complications.proper oxygenation ensured before administration (1-2 mg IV every 20 min for adult)
2-Oximes: they reactivate cholinesterase enzymes hence correct M,N and central effects. Protect from intermediate syndrome, atropie pre-ttt is essential
=Carbamates have short duration and do not require oximes.

Question 2

When is atropine stopped in TTT of OPC toxicity?

Answer 2

1. Dryness of pulmonary secrtion
   2.relief of bronchospasm and wheezes
   BUT NOT HR or pupil size

Question 3

When to discharge a case of OPC toxicity?

Answer 3

1-2 days after pateint is astmptomatic without requiring administartion of atropine or oximes

Question 4

Mention phases of phospides toxicity

Answer 4

1st phase: GI, CNS, CVS, respiratory and metabolic symptoms (1-24 hr)
2nd phase: apparent recovery (24-48 hr)
3rd phase: severe toxic hepatitis (36-7 days)

Question 5

Mention the role of elimination in phosphides toxicity

Answer 5

GL using NaHCO3
AC