pharm Flashcards
(296 cards)
1
Q
which drugs can precipitate an attack of acute intermittent porphyria?
A
barbiturates
benzodiazepines
halothane
alcohol
oral contraceptive pill
sulphonamides
2
Q
how much adrenaline is used in different situations?
A
anaphylaxis: 0.5ml 1:1,000 IM
cardiac arrest: 10ml 1:10,000 IV or 1ml of 1:1000 IV
3
Q
how is accidental adrenaline injection managed?
A
local infiltration of phentolamine
4
Q
which drugs act as alpha 1/beta 1/2 agonists/ antagonists?
A
Alpha-1 agonists
phenylephrine
Alpha-2 agonists
clonidine
Beta-1 agonists
dobutamine
Beta-2 agonists
salbutamol
Alpha antagonists alpha-1: doxazosin alpha 1a: tamsulosin - alpha-2: yohimbine non-selective: phenoxybenzamine (previously used in peripheral arterial disease)
Beta antagonists
beta-1: atenolol
non-selective: propranolol
5
Q
what do the different alpha adrenoreceptors do?
A
Alpha-1 vasoconstriction relaxation of GI smooth muscle salivary secretion hepatic glycogenolysis
Alpha-2
mainly presynaptic: inhibition of transmitter release (inc NA, Ach from autonomic nerves)
inhibits insulin
platelet aggregation
6
Q
what do the different B adrenoreceptors do?
A
Beta-1
mainly located in the heart
increase heart rate + force
Beta-2
vasodilation
bronchodilation
relaxation of GI smooth muscle
Beta-3
lipolysis
7
Q
what drugs can be used for alcohol addiction?
A
disulfram: promotes abstinence - alcohol intake causes severe reaction due to inhibition of acetaldehyde dehydrogenase. Patients should be aware that even small amounts of alcohol (e.g. In perfumes, foods, mouthwashes) can produce severe symptoms. Contraindications include ischaemic heart disease and psychosis
acamprosate: reduces craving, known to be a weak antagonist of NMDA receptors, improves abstinence
8
Q
how does allopurinol work?
A
inhibiting xanthine oxidase.
9
Q
when should allopurinol be initiated?
A
2 weeks after an attack .. thought to precipitate an attack.
after 1st attack
colchicine should be considered when using allopurinol
10
Q
what is the dose of allopurinol?
A
initial dose of 100 mg od, with the dose titrated every few weeks to aim for a serum uric acid of < 300 µmol/l. Lower initial doses should be given if the patient has a reduced eGFR
11
Q
what are the serious adverse effects of allopurinol?
whos at risk of this?
A
dermatological..
advised to stop immediately if they develop a rash…
severe cutaneous adverse reaction (SCAR)
drug reaction with eosinophilia and systemic symptoms (DRESS)
Stevens-Johnson syndrome
Chinese, Korean and Thai people
HLA-B *5801 allele.
12
Q
how does allopurinol interact with azothioprine?
A
increases effects of azothioprine
13
Q
how does allopurinol interact with cyclophosphamide?
A
reduces renal clearance and thus increases risk of marrow toxicity of cyclophosphamide
14
Q
how does allopurinol interact with theophylline?
A
allopurinol causes an increase in plasma concentration of theophylline by inhibiting its breakdown
15
Q
why does amiodarone lead to hypothyroid?
A
thought to be due to the high iodine content of amiodarone causing a Wolff-Chaikoff effect
This is an autoregulatory phenomenon where thyroxine formation is inhibited due to high levels of circulating iodide
16
Q
what are the different types of amiodarone induced thyrotoxicosis?
A
type 1
- excess iodine induced thyroid hormone synthesis.
- goitre
- treat with carbimazole
type 2
- amiodarone related destructive thyroiditis
- treat with steroids.
17
Q
should amiodarone be stopped if it causes thyroid dysfunction?
A
hypo - can continue if needed
hyper - should be stopped
18
Q
how does propofol work?
A
GABA receptor agonist
Rapid onset of anaesthesia
Pain on IV injection
19
Q
does sodium thiopentone have a slow or rapid onset of action?
A
very rapid.
often used for rapid sequence induction.
20
Q
how does ketamine work?
A
NMDA receptor antagonist
May be used for induction of anaesthesia
Has moderate to strong analgesic properties
Produces little myocardial depression making it a suitable agent for anaesthesia in those who are haemodynamically unstable
21
Q
which anaesthetic agents have little cardiovascular effects?
A
etomidate
ketamine
22
Q
What is the mechanism of class 1a antiarrhythmics? give examples of drugs in this class
A
Procainamid, quinidine, Disopyramide
blocks Na channels and increases AP duration
23
Q
what is a side effect of:
quinidine
procainamide?
A
quinidine - headache, tinnititus, thrombocytopenia
procainamide - drug induced lupus
24
Q
What is the mechanism of class 1b antiarrhythmics? give examples of drugs in this class
A
blocks Na channels and decreases AP duration
Lidocaine
Mexiletine
Tocainide
25
```
What is the mechanism of class 1c antiarrhythmics?
give examples of drugs in this class
```
blocks Na channel , no effect on AP duration
Flecainide
Encainide
Propafenone
26
What is the mechanism of class II antiarrhythmics?
B blockers
27
```
What is the mechanism of class III antiarrhythmics?
give examples.
```
```
K+ channel blockers
miodarone
Sotalol
Ibutilide
Bretylium
```
28
```
What is the mechanism of class IV antiarrhythmics?
give examples.
```
Ca CB
Verapamil
Diltiazem
29
which antibiotics effect cell wall synthesis?
peptidoglycan cross linking: carbopenems, penicillin, cephalosporins
peptidoglycan synthesis: glycopeptides e.g vancomycin
30
which antibiotics affect protein synthesis?
30S subunit: aminoglycosides, tetracyclines
50S: macrolides, chloramphenicol, clindamycin, linezolid, streptogrammins
31
what anitbiotics affect DNA?
DNA topoisomerase - Quinolones
damages DNA - metronidazole
32
which antibiotic effects RNA polymerase?
rifampicin
33
which antibiotics affect folate synthesis?
dihydrofolate reductase: trimethroprim
dihydroptorate synthase : sulphonamides
34
how does aspirin work?
blocking the action of both cyclooxygenase-1 and 2.
Cyclooxygenase is responsible for prostaglandin, prostacyclin and thromboxane synthesis.
The blocking of thromboxane A2 formation in platelets reduces the ability of platelets to aggregate
35
which drugs potentiate aspirin?
warfarin
steroids
oral hypoglycaemics
36
what age is aspirin contraindicated?
Aspirin should not be used in children under 16 due to the risk of Reye's syndrome. An exception is Kawasaki disease, where the benefits are thought to outweigh the risks.
37
what are the features of a B blocker overdose?
bradycardia
hypotension
heart failure
syncope
38
how is B blocker overdose managed?
atropine for bradycardia
| if resistant - glucagon
39
what are the two groups of CaCB?
mainly affects on myocardium - diltiazam and verapamil
mainly affects on peripheral blood - Nifedipine, amlodipine, felodipine
40
what are the indications/use of verapamil?
Angina, hypertension, arrhythmias
Highly negatively inotropic
Should not be given with beta-blockers as may cause heart block
41
what are the indications/use of diltiazam?
Angina, hypertension
Less negatively inotropic than verapamil but caution should still be exercised when patients have heart failure or are taking beta-blockers
42
what are indications/ use of Nifedipine, amlodipine, felodipine
HTN, raynauds, angina
43
what are the side effects of CaCB?
verapamil: Heart failure, constipation, hypotension, bradycardia, flushing
diltiazam: Hypotension, bradycardia, heart failure, ankle swelling
amlodipine etc: Flushing, headache, ankle swelling
44
what is the pathogenesis behind carbon monoxide poisoning?
has high affinity for Hb and myoglobin therefore left shift in dissociation curve - tissue hypoxia
45
what are the features of carbon monoxide toxicity?
```
headache: 90% of cases
nausea and vomiting:
vertigo:
confusion:
subjective weakness
severe toxicity: 'pink' skin and mucosae, hyperpyrexia, arrhythmias, extrapyramidal features, coma, death
```
46
what Ix is useful / not useful for CO poisoning?
pulse oximetry - unreliable, will be high as carboxyHb gives same as oxyHb
blood gas - reliable.
47
how is carbon monoxide poisoning managed?
high flow O2
target sats 100%
for atleast 6 hours
until symptoms have resolved
hyperbaric chamber
48
what are the indications of using a hyperbaric O2 chamber?
CO poisoning AND.... loss of consciousness at any point, neurological signs other than headache, myocardial ischaemia or arrhythmia and pregnancy as indications for hyperbaric oxygen
49
what is the mechanism of cyclosporin?
immunosuppressant which decreases clonal proliferation of T cells by reducing IL-2 release.
It acts by binding to cyclophilin forming a complex which inhibits calcineurin, a phosphatase that activates various transcription factors in T cells
50
what are the ADRs of cyclosporin?
nephrotoxicity
hepatotoxicity
fluid retention
hypertension
hyperkalaemia
hypertrichosis - hair growth
gingival hyperplasia
tremor
impaired glucose tolerance
hyperlipidaemia
increased susceptibility to severe infection
51
when might ciclosporin be indicated?
```
following organ transplantation
rheumatoid arthritis
psoriasis (has a direct effect on keratinocytes as well as modulating T cell function)
ulcerative colitis
pure red cell aplasia
```
52
how does cocaine work?
cocaine blocks the uptake of dopamine, noradrenaline and serotonin
53
what are the cardiovascular effects of cocaine?
coronary artery spasm → myocardial ischaemia/infarction
both tachycardia and bradycardia may occur
hypertension
QRS widening and QT prolongation
aortic dissection
54
what are the neuro effects of cocaine?
seizures
mydriasis
hypertonia
hyperreflexia
55
other than neuro/ CVS effects, what are the other S.E of cocaine?
ischaemic colitis
hyperthermia
metabolic acidosis
rhabdomyolysis
56
how is cocaine toxicity managed?
benzodiazepines are generally first-line for most cocaine-related problems
chest pain: benzodiazepines + glyceryl trinitrate.
hypertension: benzodiazepines + sodium nitroprusside
the use of beta-blockers in cocaine-induced cardiovascular problems is a controversial issue.
57
what are the contrainidication of COCPs?
relative - probably not worth the risk if...
more than 35 years old and smoking less than 15 cigarettes/day
BMI > 35 kg/m^2*
family history of thromboembolic disease in first degree relatives < 45 years
controlled hypertension
immobility e.g. wheel chair use
carrier of known gene mutations associated with breast cancer (e.g. BRCA1/BRCA2)
current gallbladder disease
diabetes
absolute:
more than 35 years old and smoking more than 15 cigarettes/day
migraine with aura
history of thromboembolic disease or thrombogenic mutation
history of stroke or ischaemic heart disease
breast feeding < 6 weeks post-partum
uncontrolled hypertension
current breast cancer
major surgery with prolonged immobilisation
58
what risk should women taking COCP be warned of?
only effective if taken correctly,
risk of blood clots
risk of cervical and breast ca
small risk of heart attack and stroke
may not be effective if on rifampicin or suffering from diarrhoea/vomitting.
59
what is the mechanism of cyanide poisoning?
Cyanide may be used in insecticides, photograph development and the production of certain metals.
Cyanide inhibits the enzyme cytochrome c oxidase, resulting in cessation of the mitochondrial electron transfer chain.
60
what are the symptoms of cyanide poisoning?
classical' features: brick-red skin, smell of bitter almonds
acute: hypoxia, hypotension, headache, confusion
chronic: ataxia, peripheral neuropathy, dermatitis
61
how is cyanide poisoning managed?
100% O2
definitive: hydroxocobalamin (intravenously), also combination of amyl nitrite (inhaled), sodium nitrite (intravenously), and sodium thiosulfate (intravenously)
62
how does digoxin work?
decreases conduction through the atrioventricular node which slows the ventricular rate in atrial fibrillation and flutter
increases the force of cardiac muscle contraction due to inhibition of the Na+/K+ ATPase pump. Also stimulates vagus nerve
digoxin has a narrow therapeutic index
63
what are the features of digoxin toxicity?
generally unwell, lethargy, nausea & vomiting, anorexia, confusion, yellow-green vision
arrhythmias (e.g. AV block, bradycardia)
gynaecomastia
64
what are the precipitating factors for digoxin toxicity?
classically: hypokalaemia
digoxin normally binds to the ATPase pump on the same site as potassium. Hypokalaemia → digoxin more easily bind to the ATPase pump → increased inhibitory effects
```
increasing age
renal failure
myocardial ischaemia
hypomagnesaemia, hypercalcaemia, hypernatraemia, acidosis
hypoalbuminaemia
hypothermia
hypothyroidism
```
drugs: amiodarone, quinidine, verapamil, diltiazem, spironolactone (competes for secretion in distal convoluted tubule therefore reduce excretion), ciclosporin. Also drugs which cause hypokalaemia e.g. thiazides and loop diuretics
65
how is digoxin toxicity managed?
Digibind
correct arrhythmias
monitor potassium
66
what is DRESS syndrome?
DRESS is an unexpected, severe reaction to medication. Several organs are affected including the skin, liver, kidneys, lungs and heart.
Patients develop a morbilliform skin rash in 80% cases which often leads to an exfoliative dermatitis, high fever, and inflammation of one or more organs.
Vesicles and bullae may be seen. Erythroderma can occur, mucosal involvement and facial swelling. The reaction usually occurs 2-8 weeks after commencing the offending drug.
May develop systematic symptoms
- haematological abnormalities (raised and low white count, eosinophilia, thrombocytopaenia, anaemia,
- enlarged lymph nodes
- kidney disease
- myocarditis, pericarditis,
- liver enlargement, hepatitis and rarely hepatic necrosis with liver failure
- lung disease (pneumonitis, pleuritis, pneumonia),
- neurological involvement which may lead to meningitis and encephalitis
- gastrointestinal symptoms, in severe cases, acute colitis and pancreatitis can occur
- endocrine abnormalities may include thyroiditis and diabetes.
67
what drugs can commonly cause DRESS syndrome?
allopurinol, anti-epileptics, antibiotics, immunosuppresants, HIV treatment and NSAIDS.
68
what is RegiSCAR diagnostic criteria for DRESS?
Patients require at least 3 of the following:
Hospitalisation
Reaction suspected to be drug related
Acute skin rash
Fever about 38ºC
Enlarged lymph nodes at two sites
Involvement of at least one internal organ
Blood count abnormalities such as low platelets, raised eosinophils or abnormal lymphocyte count.
69
how can DRESS syndrome be diagnosed?
Skin biopsy can help to confirm the diagnosis.
This may show inflammatory infiltrate in particularly eosinophils, extravasated erythrocytes and oedema.
Regular blood tests
Investigations looking for complications should be undertaken including ECG, CXR, echocardiogram, and urinalysis.
70
how is DRESS syndrome managed?
Antihistamines, topical steroids and emollients can be used to help control the rash.
Careful fluid balance
Systemic steroids may be started in severe cases where exfoliative dermatitis / pneumonitis / hepatitis is present.
Occasionally immunosuppressants, intravenous immunoglobulin and plasmapheresis may be started. Potential culprit drugs should not be restarted again.
71
when are dopamine receptor agonists indicated?
Parkinson's disease
prolactinoma/galactorrhoea
cyclical breast disease
acromegaly
72
give examples of dopamine receptor agonists...
e.g. bromocriptine, ropinirole, cabergoline, apomorphine
73
what are the side effects of dopamine receptor agonists?
ergot-derived dopamine receptor agonists (bromocriptine, cabergoline) have been associated with pulmonary, retroperitoneal and cardiac fibrosis.
ESR, creatinine and chest x-ray should be obtained prior to treatment and patients should be closely monitored
nausea/vomiting
postural hypotension
hallucinations
daytime somnolence
74
which drugs cause agranulocytosis?
Cytotoxic drugs - methotrexate
Antithyroid drugs - carbimazole, propylthiouracil
Antipsychotics - atypical antipsychotics (CLOZAPINE)
Antidepressant - mirtazapine
Antiepileptics - carbamazepine
Antibiotics - penicillin, chloramphenicol, co-trimoxazole
75
what are the most common drugs that can cause urticaria?
aspirin
penicillins
NSAIDs
opiates
76
For the following drugs what is the monitoring regimes..
a) statins
b) ACEi
c) amiodarone
statins LFTs - at baseline, 3 months, 12 months
ACIi - U&Es - prior to treatment, after increasing dose, atleast annually after that.
amiodarone: TFT, LFT, U&E, CXR prior to treatment
TFT, LFT every 6 months
77
For the following drugs what is the monitoring regimes..
a) methotrexate
b) azothioprine
methotrexate: FBC, UEs, LFTs before starting treatment and repeated weekly until therapy stabilised, thereafter patients should be monitored every 2-3 months
azothioprine:
FBC, LFT before treatment
FBC weekly for the first 4 weeks
FBC, LFT every 3 months
78
For the following drugs what is the monitoring regimes..
a) lithium
b) sodium valproate
c) glitazones
lithium - TFT, U&E prior to treatment
Lithium levels weekly until stabilised then every 3 months
TFT, U&E every 6 months
sodium valproate: LFT, FBC before treatment
LFT 'periodically' during first 6 months
glitazones: LFT before treatment
LFT 'regularly' during treatment
79
which drugs can impair glucose tolerance?
```
thiazides
steroids
tacrolimus, ciclosporin
interferon-alpha
nicotinic acid
antipsychotics
```
B blockers too slightly
80
which drugs can induce thrombocytopenia?
quinine
abciximab
NSAIDs
diuretics: furosemide
antibiotics: penicillins, sulphonamides, rifampicin
anticonvulsants: carbamazepine, valproate
heparin
81
which drugs can induce urinary retention?
```
tricyclic antidepressants e.g. amitriptyline
anticholinergics
opioids
NSAIDs
disopyramide
```
82
which drugs cause lung fibrosis?
amiodarone
cytotoxic agents: busulphan, bleomycin
anti-rheumatoid drugs: methotrexate, sulfasalazine
nitrofurantoin
ergot-derived dopamine receptor agonists (bromocriptine, cabergoline, pergolide)
83
which drugs can cause optic neuritis?
ethambutol
amiodarone
metronidazole
84
what can steroids do to the eyes?
cataractss
85
which drugs can induce photosensitivity?
```
thiazides
amiodarone
tetracyclines, sulphonamides, ciprofloxacin
NSAIDs e.g. piroxicam
psoralens
sulphonylureas
```
86
which drugs act on serotonin receptors?
sumatriptan is a 5-HT1D receptor agonist
ergotamine is a partial agonist of 5-HT1 receptors
pizotifen is a 5-HT2 receptor antagonist used in the prophylaxis of migraine attacks.
Methysergide is another antagonist of the 5-HT2 receptor but is rarely used due to the risk of retroperitoneal fibrosis
cyproheptadine is a 5-HT2 receptor antagonist which is used to control diarrhoea in patients with carcinoid syndrome
ondansetron is a 5-HT3 receptor antagonist and is used as an antiemetic
87
what are the features of ecstasy toxicity?
neurological: agitation, anxiety, confusion, ataxia
cardiovascular: tachycardia, hypertension
hyponatraemia
hyperthermia
rhabdomyolysis
88
how is ecstacy toxicity managed?
supportive
| dantrolene can be used for hyperthermia
89
where is ethylene glycol found?
anti-freeze
90
what are the stages of ethylene glycol toxicity?
Stage 1: symptoms similar to alcohol intoxication: confusion, slurred speech, dizziness
Stage 2: metabolic acidosis with high anion gap and high osmolar gap. Also tachycardia, hypertension
Stage 3: acute kidney injury
91
how is ethylene glycol toxicity managed?
used to be ethanol which competes with ethylene glycol for the enzyme alcohol dehydrogenase
this limits the formation of toxic metabolites
fomepizole, an inhibitor of alcohol dehydrogenase, is now used first-line in preference to ethanol
haemodialysis also has a role in refractory cases
92
what is the action of finesteride?
inhibitor of 5 alpha-reductase, an enzyme which metabolises testosterone into dihydrotestosterone.
93
what are the indications for fenasteride?
male pattern baldness
| BPH
94
what does finesteride do to PSA?
decreases levels
95
what are the indications of finasteride?
impotence
decrease libido
ejaculation disorders
gynaecomastia and breast tenderness
96
what class drug does flecainide belong to?
class 1c antiarrhythmics
97
when is flecanide contraindicated?
post myocardial infarction
structural heart disease: e.g. heart failure
sinus node dysfunction; second-degree or greater AV block
atrial flutter
98
when is flecanide indicated?
atrial fibrillation
| SVT associated with accessory pathway e.g. Wolf-Parkinson-White syndrome
99
what are the adverse effects of flecainide?
```
negatively inotropic
bradycardia
proarrhythmic
oral paraesthesia
visual disturbances
```
100
what are the adverse effects of gentamicin?
ototoxic - vestibular nerve damage, irreversible.
nephrotoxic - acute tubular necrosis. use with furosemide increases risk.
dosing required due to this
101
what are the contraindications of gentamicin use?
myasthenia gravis
102
which drugs can be cleared by haemodialysis?
```
BLAST:
barbiturates.
lithium
alcohol
salicyclates
theophyllines
```
103
which drugs cant be cleared by haemodialysis?
```
tricyclics
benzodiazepines
dextropropoxyphene (Co-proxamol)
digoxin
beta-blockers
```
104
how does heparin work?
by activating antithrombin III
e.g. lmwh increases action of ATIII on factor Xa.
105
what are the adverse effects of heparin?
bleeding
thromocytopenia (lower risk in LMWH)
osteoporosis (lower risk in LMWH)
hyperK
106
how is heparin given compared to LMWH?
LMWH sub cut
| heparain - IV
107
what is the mechanism behind heparin induced thrombocytopenia?
immune mediated - antibodies form against complexes of platelet factor 4 (PF4) and heparin
these antibodies bind to the PF4-heparin complexes on the platelet surface and induce platelet activation by cross-linking receptors
usually does not develop until after 5-10 days of treatment
108
how does heparin induced thrombocytopenia present?
despite being associated with low platelets HIT is actually a prothrombotic condition
features include reduction in platelets, thrombosis and skin allergy
109
how is heparin overdose reversed?
protamine sulphate, although this only partially reverses the effect of LMWH.
110
what is the mechanism of action of
a) statin
b) ezetimibe
c) nicotinic acid
d) fibrates
e) cholestyramine
a) HMG coA reductase inhibitor
b) decreases cholesterol absorption in the small intestine
c) decreases hepatic VLDL
d) agonist of PPAR-a and so increases lipoprotein lipase expression
e) Decreases bile acid reabsorption in the small intestine, upregulating the amount of cholesterol that is converted to bile acid
111
what are the side effects of
a) statin
b) ezetimibe
c) nicotinic acid
d) fibrates
e) cholestyramine
a) myositis, deranged LFTs
b) headache
c) flushing, myositis
d) myositis, pruritis, cholestasis
e) GI side effects
112
what are the causes of low Mg
```
PPI, diuretics,
TPN
diarrhoea
hypoK
hyperCa
alcohol
gitleman/bartters
```
113
what are the features of hypocalcaemia?
paraesthesia
tetany
seizures
arrhythmias
ECG features similar to those of hypokalaemia
exacerbates digoxin toxicity
114
how is low Mg managed?
if <0.4 or arrhyhmias, seizures, tetany - IV MG SO4
otherwise oral
115
what can lithium toxicity be precipitated by?
dehydration
renal failure
drugs: diuretics (especially thiazides), ACE inhibitors/angiotensin II receptor blockers, NSAIDs and metronidazole
116
what are the features of lithium toxicity?
```
coarse tremor (a fine tremor is seen in therapeutic levels)
hyperreflexia
acute confusion
polyuria
seizure
coma
```
117
how is lithium toxicity managed?
mild-moderate toxicity may respond to volume resuscitation with normal saline
haemodialysis may be needed in severe toxicity
sodium bicarbonate is sometimes used
118
what effect does adrenaline have on anaesthetic drugs?
drenaline may be added to local anaesthetic drugs. It prolongs the duration of action at the site of injection and permits usage of higher doses
119
where is a photosensitive rash likely to present?
forehead and arms
120
what are the side effects of metformin?
GI symptoms
| lactic acidosis
121
what are the side effects of sulphonylureas?
weight gain
hypoglycaemia
SiADH
liver dysfunction.
122
what is chlorpropamide?
sulphonlyurea
123
what are the side effects of glitazones?
weight gain
liver dysfunction
fluid retention
fracture
124
what are the side effects of gliptins?
pancreatitis.
125
when is lithium monitored?
12 hours post dose
126
when is phenytoin monitored?
Phenytoin levels do not need to be monitored routinely but trough levels, immediately before dose should be checked if:
adjustment of phenytoin dose
suspected toxicity
detection of non-adherence to the prescribed medication
127
when is ciclosporin monitored?
immediately before
128
when should digoxin be monitored?
6 hours post dose
129
after causative substance ingestion what time frame should ogd be avoided?
5-15 dys due to oesophageal strength being at its weakess
130
what does st johns wort do?
treats mild depression. similar action to ssri
131
what are the adverse effects of st johns wort?
induces cytochorme p450
therefore reduces efficacy of e.g. warfarin, cyclosporin, COCP
similar adverse effects to placebo
may cause serotonin syndrome
132
what is Trastuzumab
herceptin - monoclonal antibody that acts on the HER2/neu receptor
133
what are the side effects of trastuzumab (herceptin)?
flu-like symptoms and diarrhoea are common
| cardiotoxicity: echo before treatemt.
134
what is the main limitation of monoclonal antibodies? how is it overcome?
Mouse antibodies are immunogenic leading to the formation of human anti-mouse antibodies (HAMAs). This problem is overcome by combining the variable region from the mouse body with the constant region from an human antibody.
135
what are the following monoclonal Ab used in?
Infliximab
rituximab
cetuximab
trastuzumab
Infliximab (anti-TNF): used in rheumatoid arthritis and Crohn's
rituximab (anti-CD20): used in non-Hodgkin's lymphoma and rheumatoid arthritis
cetuximab (epidermal growth factor receptor antagonist): used in metastatic colorectal cancer and head and neck cancer
trastuzumab (HER2/neu receptor antagonist): used in metastatic breast cancer
136
where are the following monoclonal Ab used?
Alemtuzumab
abciximab
OKT3
alemtuzumab (anti-CD52): used in chronic lymphocytic leukaemia
abciximab (glycoprotein IIb/IIIa receptor antagonist): prevention of ischaemic events in patients undergoing percutaneous coronary interventions
OKT3 (anti-CD3): used to prevent organ rejection
137
how is tremor related to lithium?
fine tremor at therapeutic levels
| course tremor at toxicity
138
which drugs reduce the efficacy of COCP?
```
rifampicin
rifaxicin
phenytoin,
phenobarbital,
carbamazepine or
St John's Wort
all enzyme indcing drugs
```
139
which two cholesterol drugs when used together give a bigger risk of muscle toxicity?
fibrates and statins - myostitis
140
what is a common side effect of verapamil?
constipation
141
which drugs should be avoided in G6PD deficiency?
sulphonylureas
ciprofloxacin
nitrofurantoin,
chloramphenicol
142
give examples of quinolones
ciprofloxacin
| levofloxacin
143
how do quinolones work?
topoisomerase inhibitors
144
what are the mechanisms of quinolone resistance?
topoisomerase mutation
| efflux pump to reduce conc of drug
145
what are the adverse effects of quinolones?
lower seizure threshold
long QT
tendon damage
cardiac damage
146
when should quinolones be avoided?
G6PD deficiency
| pregnancy/ breast feeding
147
what types of reactions are involved in phase 1 drug metabolism
oxidation
reduction
hydrolysis
mainly carried out by p450 enzymes
148
what types of reactions are involved in phase 2 drug metabolism
conjugation to inactive products for excretion
149
what is first pass metabolism?
Phenomenon where the concentration of a drug is greatly reduced before it reaches the systemic circulation due to hepatic metabolism. As a consequence much larger doses are need orally than if given by other routes.
150
what is zero order kinetics?
Zero-order kinetics describes metabolism which is independent of the concentration of the reactant. This is due to metabolic pathways becoming saturated resulting in a constant amount of drug being eliminated per unit time.
151
which drugs exhibit zero order kinetics?
phenytoin
salicylates (e.g. high-dose aspirin)
heparin
ethanol
152
which drugs are affected by the acetylator status?
50% of population is deficient in hepatic N-acetyltransferase and this is known as your acetylator status.
```
isoniazid
procainamide
hydralazine
dapsone
sulfasalazine
```
153
which drugs are inducers of p450?
antiepileptics: phenytoin, carbamazepine
barbiturates: phenobarbitone
rifampicin
St John's Wort
chronic alcohol intake
griseofulvin
smoking - smokers require more aminophylline
154
which drugs inhibit p450?
```
antibiotics: ciprofloxacin, erythromycin
isoniazid
cimetidine,omeprazole
amiodarone
allopurinol
imidazoles: ketoconazole, fluconazole
SSRIs: fluoxetine, sertraline
ritonavir
sodium valproate
acute alcohol intake
quinupristin
```
155
how does pilocarpine work?
Pilocarpine is a muscarinic agonist that is sometimes used in the treatment of glaucoma.
It is thought to reduce intraocular pressure by widening the trabecular spaces and allowing for increased aqueous flow.
Muscarinic receptors are found in the ciliary muscles and iris sphincter, therefore it also causes pupillary constriction.
Miosis usually persists for 4-8 hours following administration.
156
how does timolol work?
beta-blocker which inhibits the production of aqueous humour.
157
what is oculogyric crisis?
dystonic reaction to certain meds e.g. metaclopramide, antipsycotics
features include restlessness, agitation
involuntary upward deviation of the eyes
158
how is oculogyric crisis managed?
Intravenous antimuscarinic: benztropine or procyclidine
159
what are the effects of methanol poisoning?
same as alcohol intoxication + visual problems
160
what is the mechanism of methanol poisoning?
formic acid
161
how is methanol poisoning managed?
fomepizole (competitive inhibitor of alcohol dehydrogenase) or ethanol
haemodialysis
cofactor therapy with folinic acid to reduce ophthalmological complications
162
what is HLA-B *5801 allele screening done for?
Screen for HLA-B *5801 allele in a patient at high risk for allopurinol induced severe cutaneous adverse reaction
163
what are risk factors for developing allopurinol sensivity?
Certain ethnic groups such as the Chinese, Korean and Thai people
CKD
diuretic use
allopurinol should be avoided in those with mild-moderate kidney diseaee
164
what is octreotide?
ong-acting analogue of somatostatin
| somatostatin is released from D cells of pancreas and inhibits the release of growth hormone, glucagon and insulin
165
when is octreotide used?
```
acute treatment of variceal haemorrhage
acromegaly
carcinoid syndrome
prevent complications following pancreatic surgery
VIPomas
refractory diarrhoea
```
166
what are the side effects of octreotide?
gallstones
167
what are the side effects of sildenafil?
visual disturbances e.g. blue discolouration, non-arteritic anterior ischaemic neuropathy
nasal congestion
flushing
gastrointestinal side-effects
headache
168
what are phosphodiesterase type 5 inhibitors?
DE5 inhibitors cause vasodilation through an increase in cGMP leading to smooth muscle relaxation in blood vessels supplying the corpus cavernosum.
used for erectile dysfunction and pulmonary HTN
e.g. sildenafil (Viagra)
tadalafil (Cialis)
vardenafil
169
what are the contraindications of phosphodiesterase type 5 inhibitors?
patients taking nitrates and related drugs such as nicorandil
hypotension
recent stroke or myocardial infarction (NICE recommend waiting 6 months)
170
which enzyme does smoking affect and what does this mean?
```
CYP1A2 enzyme (of p450 system)
smokers usually require more aminophylline.
```
171
what drug is MCAT similar to?
similar to MDMA, amphetamines and cocaine, resulting in increased levels of serotonin, dopamine and noradrenaline, resulting in a 'high' and feeling of euphoria
similar risk of causing serotonijn syndrome
172
what drug group is mexxy similar too?
new illegal high - hallucinogen
173
what drug is GHB?
| what is the major side effect
similar to liquid ectasy
| can cause resp depression esp when taken with alcohol
174
what should be done if a patient is having unbearable GI effects from metformin?
switch to modified release
| if still no good try a sitagliptin/gliclazide
175
how does metformin work?
acts by activation of the AMP-activated protein kinase (AMPK)
increases insulin sensitivity
decreases hepatic gluconeogenesis
may also reduce gastrointestinal absorption of carbohydrates
176
what are the adverse effects of metformin?
GI - nausea, anorexia, diarrhoea
reduced b12 absorption - rarely an issue
lactic acidosis with severe liver disease or renal failure
177
what are the contraindications of using metformin?
CKD - dose should be reviewed if the creatinine is > 130 µmol/l (or eGFR < 45 ml/min) and stopped if the creatinine is > 150 µmol/l (or eGFR < 30 ml/min)
metformin may cause lactic acidosis if taken during a period where there is tissue hypoxia. Examples include a recent myocardial infarction, sepsis, acute kidney injury and severe dehydration
iodine-containing x-ray contrast media: increasing risk of provoking renal impairment due to contrast nephropathy; metformin should be discontinued on the day of the procedure and for 48 hours thereafter
alcohol abuse - relative contraindication
178
how does rifampicin work? what are the side effects?
inhibits bacterial DNA dependent RNA polymerase preventing transcription of DNA into mRNA
hepatitis, orange secretions
flu-like symptoms
179
how does isoniazid work? what are the side effects?
inhibits mycolic acid synthesis
peripheral neuropathy: prevent with pyridoxine (Vitamin B6)
hepatitis, agranulocytosis
liver enzyme inhibitor
180
how does Pyrazinamide work? what are the side effects?
converted by pyrazinamidase into pyrazinoic acid which in turn inhibits fatty acid synthase (FAS) I
hyperuricaemia causing gout
arthralgia, myalgia
hepatitis
181
how does ethambutol work? what are the side effects?
inhibits the enzyme arabinosyl transferase which polymerizes arabinose into arabinan
optic neuritis: check visual acuity before and during treatment
dose needs adjusting in patients with renal impairment
182
what are the features of Organophosphate insecticide poisoning?
```
Ach build up .. presents as SLUD..
salivation
lacrimaton
urinary incontinence
diarrhoea
others - bradycardia and hypotension, small pupils and muscle fasciculations.
```
183
how is Organophosphate insecticide poisoning managed?
atropine
184
what is the mechanism of aspirin?
Aspirin is a non reversible COX 1 and 2 inhibitor
185
what are the features of salicylate overdose?
mixed respiratory alkalosis and metabolic acidosis
early stimulation of resp system leads to resp alkalosis
later acid effects of salicylates + renal fialure leads to metabolic acidosis
```
hyperventilation (centrally stimulates respiration)
tinnitus
lethargy
sweating, pyrexia
nausea/vomiting
hyperglycaemia and hypoglycaemia
seizures
coma
```
186
how is salicylate poisoning managed?
general (ABC, charcoal)
urinary alkalinization with intravenous sodium bicarbonate - enhances elimination of aspirin in the urine
haemodialysis
187
what are the indications for haemodyalysis in salicylate poisoning?
```
serum concentration > 700mg/L
metabolic acidosis resistant to treatment
acute renal failure
pulmonary oedema
seizures
coma
```
188
what are the features of tricyclic overdose?
anticholinergic effects early on - dry mouth, dilated pupils, agitation, sinus tachycardia, blurred vision.
```
features of severe poisoning:
arrhythmias
seizures
metabolic acidosis
coma
```
189
what are the ECG changes in tricyclic overdose?
sinus tachycardia
widening of QRS
prolongation of QT interval
190
in tricyclic OD what is the QRS changes associated with?
Widening of QRS > 100ms is associated with an increased risk of seizures whilst QRS > 160ms is associated with ventricular arrhythmias
191
How is tricyclic OD managed?
IV bicarbonate
- first-line therapy for hypotension or arrhythmias
can also use other drugs for arrhythmias
Intravenous lipid emulsion is increasingly used to bind free drug and reduce toxicity
dialysis is ineffective in removing tricyclics
192
what are the indications for IV bicarbonate in tricyclic OD?
widening of the QRS interval >100 msec or a ventricular arrhythmia
193
which drugs are contraindicated in tricyclic OD?
+ class 1a (e.g. Quinidine) and class Ic antiarrhythmics (e.g. Flecainide) are contraindicated as they prolong depolarisation
class III drugs such as amiodarone should also be avoided as they prolong the QT interval
194
what are the causes of raised anion gap?
```
lactic acidosis
ketoacidosis
renal failure (high urate)
toxins such as methanol, ethylene glycol, salicylates
```
195
what type of drug is tamoxifen?
Selective oEstrogen Receptor Modulator (SERM) which acts as an oestrogen receptor antagonist and partial agonist.
196
what are the ADRs of tamoxifen?
hot flushes
menstural disturbances
VTE
endometrial Ca
197
how long is tamoxifen used?
5 years after removal of tumour
198
what is raloxifene?
Raloxifene is a pure oestrogen receptor antagonist, and carries a lower risk of endometrial cancer
199
which antibiotic lowers seizure threshold?
ciprofloxacin
200
which antibiotic can increase QT?
erythromycin
201
which Abx can interact with alcohol?
metronidazole
202
what is a complication of methanol poisoning?
visual disturbance
| metabolite of methanol, formic acid, accumulates in the optic nerve causing visual disturbance and eventually blindness.
203
what is meant by efficacy and potency of a drug?
'Efficacy' is the measure of how able an agonist is to produce a response once it has bound to the receptor.
'Potency' is related to the concentration at which a drug is effective.
204
which method of VTE prophylaxis should be used in renal failure?
unfractionated heparin.
LMWH should not be used
Current NICE guidelines state that unfractionated heparin (UFH) is the anticoagulant of choice in patients with severe chronic kidney disease.
205
does diazepam undergo first pass metabolism?
no
206
what factors are associated with increased hepatotoxicity with paracetamol OD?
chronic alcohol intake
carbemazepine
malnutrition- due to depletion of glutathione
st johns wart
(acute alcohol intake IS NOT associated with increased toxicity - may actually be protective)
207
which drugs are seemed to be harmful in pregnancy?
Antibiotics
tetracyclines
aminoglycosides
sulphonamides and trimethoprim
quinolones: the BNF advises to avoid due to arthropathy in some animal studies
some reports of co-amox causing necrotising entercolitis
```
Other drugs
ACE inhibitors, angiotensin II receptor antagonists
statins
warfarin
sulfonylureas
retinoids (including topical)
cytotoxic agents
```
The majority of antiepileptics including valproate, carbamazepine and phenytoin are known to be potentially harmful. however risk of seizure is also harmful.
208
which antibiotic allergy is associated with penicillin allergy?
cephalosporins e.g. cefalexin
Penicillins, cephalosporins, and carbapenems are all members of the beta-lactam group of antibiotics and share a common beta-lactam ring.
cefixime, cefotaxime, ceftazidime, ceftriaxone, or cefuroxime - have less risk
cefalexin - should be avoided in pen allergy
209
what is timentin?
ticarcillin with clavulanic acid
| contains penicillin
210
which Abx is contraindiciated in G6PD deficinecy?
quinolones e.g. ciprofloxacin
211
which drug can precipitate lithium toxicity?
drugs: diuretics (especially thiazides), ACE inhibitors/angiotensin II receptor blockers, NSAIDs and metronidazole.
212
how is paracetamol normally metabolised? what happens in overdose
conjugation with glucuronic acid/sulphate.
in overdose this becomes saturated and instead there is oxidation by p450 leading to toxic metabolites
glutathione can conjugate this metabolite into non-toxic form.
if glutathione stores also become saturated it can lead to damage - hepatocytes and renal cells
213
what chemical can help with paracetamol OD. how does this work?
N-acetyl cysteine is used in the management of paracetamol overdose as it is a precursor of glutathione and hence can increase hepatic glutathione production
214
why is there a lower threshold for treating paracetamol OD in patients on phenytoin/rifampicin?
these are p450 inducing agents.
| thus paracetamol is oxidised into toxic metabolites quicker.
215
which drug can give green vision?
digoxin
216
what is the action of pilocarpine?
muscarinic agonist
pupillary constriction and contraction of the ciliary muscles, which opens up the trabecular meshwork allowing greater drainage of aqueous humour and reduces intraocular pressure.
217
what is sarin gas? what affect does poisoning with this have?
Sarin gas is a highly toxic synthetic organophosphorus compound which causes inhibition of the enzyme acetylcholinesterase
excess ACh levels
218
what are the effects of excess ACh?
```
he effects of excessive ACh can be remembered by the mnemonic DUMBELLS:
Diarrhoea
Urination
Miosis/muscle weakness
Bronchorrhea/Bradycardia
Emesis
Lacrimation
Salivation/sweating
```
219
name 3 macrolides
erythromycin
azithromycin
clarithromycin
220
how do macrolides work?
inhibit translocation
221
what is the mechanism of macrolide resistance?
post-transcriptional methylation of the 23S bacterial ribosomal RNA
222
what are the ADRs of macrolides?
prolongation of the QT interval
gastrointestinal side-effects are common. Nausea is less common with clarithromycin than erythromycin
cholestatic jaundice
P450 inhibitor
azithromycin is associated with hearing loss and tinnitus
223
what are the DDIs of macrolides
statins should be stopped whilst taking a course of macrolides.
Macrolides inhibit the cytochrome P450 that metabolises statins.
increases the risk of myopathy and rhabdomyolysis.
224
what are the features of mercury poisoning?
```
paraesthesia
visual field defects
hearing loss
irritability
renal tubular acidosis
```
225
how can motion sickness be managed?
hyoscine (e.g. transdermal patch) - most effective treatment.
non-sedating antihistamines such as cyclizine or cinnarizine are recommended in preference to sedating preparation such as promethazine
226
what does digoxin do to QT interval?
shorten it
227
how do aminoglycosides cause AKI?
e.g. gentamicin
| acute tubular necrosis
228
which meds can cause renal injury via Acute interstitial nephritis ?
penicillins, quinolones and diuretics
229
which drugs can cause crystal nephropathy?
methotrexate and ganciclovir
230
how should amiodarone induced hypothyroid be managed?
cont amiodarone, start thyroxine
231
how should metformin be initiated?
start slow and titrate - 500mg OD for 2 weeks then BD, then review.
232
which two tumours are known to over express HER2?
breast
| gastric adenocarcinoma
233
How is HER2 positive gastric adenocarcinoma treated?
NICE state trastuzumab in combination with cisplatin and capecitabine or 5-fluorouracil is a recommended option for HER2 positive metastatic adenocarcinoma of the stomach.
234
which cancers over express HER1? which monoclonal can be used here?
squamous and colorectal
| Cetuximab
235
what is muddy brown casts on urinalysis indicative of?
acute tubular necrosis
236
when can charcoal be used in paracetamol OD?
within 1 hour
237
when should N-acetylcysteine be given in paracetamol OD?
if there is a staggered overdose or there is doubt over the time of paracetamol ingestion, regardless of the plasma paracetamol concentration;
OR
the plasma paracetamol concentration is on or above a single treatment line joining points of 100 mg/L at 4 hours and 15 mg/L at 15 hours, regardless of risk factors of hepatotoxicity
238
how quickly is Nacetylcysteine transfused?
over 1 hour
239
what is one allergic complication of N-acetylcysteine?
can cause anaphalactoid reaction.
| should be stopped and restarted at slower rate
240
what is the kings college criteria for liver transplant after paracetamol OD?
Arterial pH < 7.3, 24 hours after ingestion
or all of the following:
prothrombin time > 100 seconds
creatinine > 300 µmol/l
grade III or IV encephalopathy
241
what is a good prognostic marker in paracetamol OD?
elevated PT - signifies poor prognosis and liver failure
242
```
how do the following work...
suxamethonium
atracurium
Vecuronium
Pancuronium
```
suxamethonium:
Depolarising neuromuscular blocker
Inhibits action of acetylcholine at the neuromuscular junction
Degraded by plasma cholinesterase and acetylcholinesterase
atracurium, vecuronium and pancuronium:
Non depolarising neuromuscular blocking drug
243
out of the muscle relaxants which is the quickest acting and shortest duration?
suxamethonium
244
what are the ADRs of suxamethonium?
hyperkalaemia,
malignant hyperthermia
and lack of acetylcholinesterase
245
how is atracurium metabolised?
not by kidney/.liver
| hydrolysed by tissues
246
what are the ADRs of atracurium?
Generalised histamine release on administration may produce facial flushing, tachycardia and hypotension
247
how is atracurium reversed?
neostigmine
| also reverses pancuronium and vecuronium
248
how is salicylate overdose managed?
urinary alkalinization with IV bicarbonate
| haemodialysis
249
what is the antidote for..
opioids
benzos
heparin
a) naloxone
b) flumazenil
c) protamine sulphate
250
how is lithium toxicity managed?
mild-moderate toxicity may respond to volume resuscitation with normal saline
haemodialysis may be needed in severe toxicity
251
how is bblocker toxicity treated?
atropine if bradycardic
| glucagon if resistant
252
how is lead poisoning managed?
dimercaprol
253
how is cyanide poisoning managed?
Hydroxocobalamin
254
which groups of patients are more at risk of developing hepatotoxicity from paracetamol OD?
```
patients taking liver enzyme-inducing drugs (rifampicin, phenytoin, carbamazepine, chronic alcohol excess, St John's Wort)
malnourished patients (e.g. anorexia nervosa) or patients who have not eaten for a few days
```
Acute alcohol intake is actually maybe protective
255
what are the following symptoms suggestive of: headache, confusion, pink mucosa, low grade fever.
CO poisoning
256
when is haemodyalysis for lithium indicated?
severe toxicity e.g.. >2 or when renal/neuro involvement
257
what affect do the following teratogens have?
ACEi
alcohol
aminoglycosides
ACEi - craniofacial abnorm , renal dysgenesis
alcohol: craniofacial abnorm
aminog - ototoxic
258
what affect do the following teratogens have?
chloramphenicol
carbemazapines
cocaine
chloramphenicol: grey baby syndrome
'
carbemazapines: neural tube defects, craniofacial
cocaine: IUGR, preterm labour
259
what affect do the following teratogens have?
warfarin
valproate
tetracyclines
warfarin: craniofacial
valproate: neural tube defects, craniofacial
tetracyclines: discoloured teeth
260
what affect do the following teratogens have?
smoking
lithium
Diethylstilbesterol
smoking: IUGR, preterm labour
lithium: ebstein anomoly
Diethylstilbesterol: vaginal clear cell adenocarcinoma
261
how does tacrolimus work?
decreases clonal proliferation of T cells by reducing IL-2 release
calcinurin inhibitor
262
what is more potent tacrolimus or ciclosporin?
tacrolimus
| also more likely to cause renal toxocity and glucose intolerance
263
what is the function of amiloride?
blocks the epithelial sodium channel in the distal convoluted tubule
also leads to high K
264
what is the function of spironolactone?
Aldosterone antagonist
| in colecting duct
265
which medications exacerbate heart failure?
pioglitazone is contraindicated as it causes fluid retention
verapamil - negative inotropic effect
NSAIDs/glucocorticoids - should be used with caution as they cause fluid retention
class I antiarrhythmics - flecainide (negative inotropic and proarrhythmic effect
266
which drugs should be avoided in renal failure?
antibiotics: tetracycline, nitrofurantoin
NSAIDs
lithium
metformin
267
which drugs need adjusting in renal failure due to accumulation?
```
most antibiotics including penicillins, cephalosporins, vancomycin, gentamicin, streptomycin
digoxin, atenolol
methotrexate
sulphonylureas
furosemide
opioids
```
268
can progesterone only pill be used while breast feeding?
yes
269
what affect may progesterone have on ovarian cysts?
increase of functional ovarian cysts.
270
what is cinchonism?
Quinine toxicity
it can be fatal, usually by cardiac arrhythmia or flash pulmonary oedema in the short term, although incipient renal failure may be fatal more long-term.
cardiac arrhythmias - long QT due to blockage of na and k channels. can lead to VT/VF
hypoglycaemia - quinine stimulates pancreatic insulin release
classical hallmarks of cinchonism are tinnitus, visual blurring, flushed and dry skin and abdominal pain.
271
why is measuring salicylate levels important in quinine toxicity?
Clinically, quinine toxicity is difficult to distinguish from aspirin poisoning
however the effects are usually reversible with aspirin and irreversible for quinine e.g. tinnitus and visual blurring
272
what drugs can cause serotonin syndrome?
MAOi
SSRIs
ecstasy
amphetamines
273
what are the features of serotonin syndrome?
```
neuromuscular excitation (e.g. hyperreflexia, myoclonus, rigidity)
autonomic nervous system excitation (e.g. hyperthermia)
altered mental state
```
274
how is serotonin syndrome managed?
supportive including IV fluids
benzodiazepines
more severe cases are managed using serotonin antagonists such as cyproheptadine and chlorpromazine
275
how does serotonin syndrome and neuroleptic malignant syndrome compare?
both have tachycardia, increased BP and fever and rigidity
serotonin syndrome has much faster onset and increased reflexes
wheereas neuroleptic malignant syndrome is slower in onset and reduced reflexes
dilated pupils in serotonin but not in neuroleptic MS
276
how is neuroleptic malignancy syndrome managed?
benzos and fluids
| severe cases - dantrolene.
277
what are the side effects of Ca blockers?
Headache
Flushing
Ankle oedema
Verapamil also commonly causes constipation
278
what are the side effects of nitrates
Headache
Postural hypotension
Tachycardia
279
what are the side effects of nicorandil
Headache
Flushing
Anal ulceration
280
what are the side effects of sulphonylureas?
Hypoglycaemic episodes
Increased appetite and weight gain
Syndrome of inappropriate ADH secretion
Liver dysfunction (cholestatic)
281
what are the side effects of glitazones?
Weight gain
Fluid retention
Liver dysfunction
Fractures
282
What is the kings college criteria for liver transplant?
pH <7.3
Creatinine > 300
PT > 100 s
Hepatic encephalopathy 3 or 4
283
What is the mechanism of rifampicin , isoniazid and pyrazinamide?
Rifampicin - inhibits DNA dep RNA pol
Isoniazid - reduces mycolic synthesis
Pyrazinamide - inhibits fatty acids
284
What are the ADRs of rifampicin
Orange secretions
Hepatitis
Flu like symptoms
Liver enzyme inducer
285
What are the side effects of isoniazid ?
Peripheral neuropathy - give pyroxidine
Hepatitis
Agranulocytosis
286
What are the side effects of pyrazinamide?
Gout
Arhralgia, myalgia
Hepatitis
287
What is side effects of ethambutol
Optic neuritis
288
What drugs should not be taken with statins ?
Macrolides - erythromycin / clarithromycin
| These inhibit p450 so statin levels rise to toxic
289
Which electrolyte can promote digoxin toxicity
HypoK
| Because digoxin competes for pottasium binding site on Na/ K ATPase
290
What are the complications of transtuzumab?
Transtuzumab = herceptin
Cardiomyopathy
Do ECHO before starting
Don’t take with antracyclines e.g doxorubicin as these also cause cardiomyopathy
291
What are the side effects of dopamine agonists
```
Fibrosis - pulmonary , retrroperitoneal
Sleepiness
Hallucination
Nausea
Postural hypotension
```
292
What should be given in tricyclic OD and when ?
IV bicarb if pH <7.1, QRS >160, arrhythmia
293
When can gastric lovage and charcoal be used
Both only within 1 hour
294
What is the dose of adrenaline in adults for cardiac arrest and anaphylaxis
Anaphylaxis - 500microG 1 in 1000 (0.5ml)
| Cardiac arrest - 1mg (1ml 1 in 1000)
295
How does methanol poisoning present and how is it treated ?
Like alcohol toxicity but with visual changes/ effects
Fomepizole
296
Which drugs have 0 order kinetics
Salicyclates
Heparin
Phenytoin
Ethanol
