PHARM

Question 1

List the 5 topical glaucoma meds

Answer 1

beta blocker
alpha-2 agonist
CAI
prostaglandin
cholinergics

Question 2

Which 3 glaucoma meds REDUCE aqueous production

Answer 2

Beta-blockers
alpha-2 agonist
CAI

Question 3

which 2 glaucoma meds INCREASE aqueous outflow

Answer 3

prostaglandin
cholinergics

Question 4

what are some SE of beta blockers

Answer 4

mask diabetic hypoglycemic response
arrhythmia, bradycardia, hypotension
asthma, bronchospasms

Question 5

what are some SE of alpha-2 agnoist

Answer 5

follicular conjunctivitis
HA, fatigue, muscle pain
dry mouth/nose

Question 6

3 SE of CAIs

Answer 6

bitter taste
ocular burning
sula allergies

Question 7

4 SE of prostaglandins

Answer 7

ocular burning/redness
darkening iris
eyelash growth (hypertrichosis)
orbital fat atrophy

Question 8

4 SE of cholinergics (pilocarpine)

Answer 8

brow ache
neurologic
parasympathetic effects
higher rate of retinal detachment (rhetorical)

Question 9

which of the topical glaucoma meds also induces miosis? hint: this is also the last class that is used w/ glaucoma

Answer 9

cholinergics– they stretch the trabecular meshwork

Question 10

name your 6 penicillins

Answer 10

penicillin
amoxicillin– extended
ampicillin– extended
zosyn— IV
augmentin– broad
dicloxacillin

Question 11

what two ingredients make up augmentin

Answer 11

amoxicillin + clavulanic acid

Question 12

what two ingredients make up zosyn

Answer 12

piperacillin + tazobactam

Question 13

penicillin is used against….. (4 things)

Answer 13

streptococcus
GP anaerobes
GN cocci
spirochetes

Question 14

Dicloxacillin is used against…

Answer 14

beta-lactamase resistant/antistaphylococcal
MSSA

Question 15

Augmentin & Zosyn is for what kind of infections?

Answer 15

polymicrobial infxn
intra-abdominal, gynecologic, skin and soft tissue
respiratory infxn
aspiration

Zosyn only– GN, pseudomonas, anaerobes, sensitive GP

Question 16

Ampicillin is used against…

Answer 16

streptococcus
enterococcus sp
listeria
some GNR

Question 17

which penicillin meds are used against enterococcus

Answer 17

ampicillin & ampoxicillin

Question 18

containdications of penicillin

Answer 18

severe allergy hx including hx of SJS w/ penicillin

Question 19

SE of penicillin class

Answer 19

thrombocytopenia & leukopenia
allergic interstitial nephritis
hyprenatremia

Question 20

which class can cross-allergic rxns happen w/ penicillin class?

Answer 20

B-lactams esp 1st gen cephalosporins

Question 21

which penicillin has increased risk of acute kidney injury when combined with vancomycin?

Answer 21

Zosyn

Question 22

name the ONLY PCN that can be taken WITH food

Answer 22

amoxicillin

Question 23

which PCN is resistant to beta-lactamase?

Answer 23

dicloxacillin

Question 24

MOA of PCN & cephalosporin classes

Answer 24

inactivate PBP to stop cell wall synthesis
bactericidal, time-dependent
kidney elimination– reduce dose in CKD

Question 25

name the two 1st gen cephalosporins

Answer 25

cephalexin and cefazolin *FA/PHA*

Question 26

name the three 2nd gen cephalosporins

Answer 26

cefprozil cefuroxime cefoxitin

Question 27

1st gen cephalosporin coverage

Answer 27

MMSA, Streptococcus PEK

Question 28

2nd gen cephalosporin coverage

Answer 28

MSSA, Streptococcus HeNPEK (includes Haemophilus & Neisseria) cefotoxin-- anaerobes

Question 29

contraindication for ALL cephalosporins

Answer 29

NOT for ppl w/ anaphylactic rxn or SJS hx with PCN or other cephalosporin (esp 3rd gen)

Question 30

are 1st, 2nd, 3rd & 4th gens broad or narrow?

Answer 30

1st-- narrow 2nd--- extended 3rd & 4th--- broad

Question 31

which cephalosporin class is best for GP coverage?

Answer 31

1st gen also has highest rate of cross-reactivity w/ PCN

Question 32

clinical indications for 1st gen cephalosporins

Answer 32

surgical prophylaxis GP skin infection pneumococcal resp. infxn UTI staph infection (bacteremia)

Question 33

name the ONLY cephalosporin that is cleared by the liver

Answer 33

ceftriaxone (3rd gen)

Question 34

clinical indications for 2nd gen cephalosporins

Answer 34

CAP skin infxn, other resp infxn mixed aerobic/anaerobic infxn

Question 35

which 2nd gen cephalosporin includes anaerobic coverage

Answer 35

cefoxitin

Question 36

which generation of cephalosporin does not cover S. Aureus?

Answer 36

3rd gen

Question 37

name the four 3rd gen cephalosporins

Answer 37

cefdinir cefpodoxime ceftriaxone ceftazidime broad spectrum

Question 38

spectrum for 3rd gen cephalosporins

Answer 38

IT DROPS MSSA keeps streptococcus & HeNPEK adds Moraxella

Question 39

which 3rd gen cephalosporin also covers pseudomonas?

Answer 39

ceftazidime can use for complicated UTI or w/ metronidazole

Question 40

which 3rd gen cephalosporin also covers meningitis?

Answer 40

ceftriaxone

Question 41

clinical indicators for 3rd gen

Answer 41

nocosomial infxn rest is same as 2nd gen

Question 42

name the only 4th gen cephalosporin

Answer 42

cefepime

Question 43

spectrum for cefepime

Answer 43

pseudomonas aerobic GN

Question 44

clinical indications for cefepime

Answer 44

intra-abd, skin/soft tissue infxn CAP, HABP/VABP, complicated UTI peritonitis, neutropenic fever sepsis/septic shock

Question 45

which cephalosporin generation has the best GN coverage

Answer 45

4th gen- cefepime

Question 46

name the only 5th gen cephalosporin

Answer 46

ceftaroline

Question 47

name the only cephalosporin that covers MRSA

Answer 47

ceftaroline (5th gen)