Pharm 2 Flashcards by Micah Shaw

Lithium indications and MOA

Mood stabilizer, first line for bipolar, interferes with ion transport, notable tremor

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Lithium contraindications

Severe CV / renal disease, dehydration, sodium depletion

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Lithium drug interactions

oodles, may enhance risk of QT prolongers

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Valproate indications and MOA

Anti-seizure, migraine prophylaxis, mania, enhances GABA

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Valproate side effects

headache, nausea, vomiting, tremor

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Valproate contraindications

pregnancy or childbearing potential

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Risperidone indications and MOA

antipsychotic, treatment of irritability/aggression with autism, blocks dopamine and serotonin receptors

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Risperidone side effects

urinary retention, weight gain, seizure, sedation, extrapyramidals, postural hypotension, sexual dysfunction, arrhythmia, xerostomia

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Imipramine indications

enuresis in children over 6, depression

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Imipramine MOA

tricyclic antidepressant, inhibits dopamine and serotonin reuptake, also block serotonergic, alpha adrenergic, histaminic, and muscarinic receptors

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Imipramine side effects

weight gain, xerostomia, constipation, urinary retention, blurry vision, tachycardia, arrhythmia, nausea, drowsiness

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Imipramine contraindications

recent MI, MAOi’s within 14 days, linezolid, methylene blue

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Desipramime indications and MOA

Tricyclic antidepressant, SNRI

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List anticonvulsants

LOVEPC
Lamotrigine
Oxcarbazepine
Valproate
Ethosuximide
Phenytoin
Carbamazapine

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fluoxetine indications and MOA

antidepressant, SSRI

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bupropion indications and MOA

antidepressant, NDRI, fewer sexual side effects than SSRI

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venlafaxine indications and MOA

antidepressant, SNRI

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SSRI side effects

nausea, anxiety, drowsiness, insomnia, sexual dysfunction, drug interactions

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tricyclic side effects

weight gain, xerostomia, constipation, urinary retention, blurry vision, tachycardia, arrhythmias, nausea, drowsiness

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common side effects of antiseizures

ataxia, n/v, sedation, rash, weight changes, teratogen, hyponatremia, osteoporosis

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phenytoin indications and MOA

generalized and tonic clonic antiseizure, blocks sodium channels

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lamotrigine indications and MOA

wide variety of seizures and bipolar disorder, sodium channel and high voltage calcium blocker

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carbamazepine indications and MOA

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focal, tonic-clonic, trigeminal neuralgia and bipolar disorder, sodium channel blocker

oxcarbazepine indications and MOA

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partial onset seizures, blocks sodium channels, modulates calcium channels

valproate indications and MOA

focal and primary generalized epilepsies, blocks sodium channels, and GABA transaminase

ethosuximide indications and MOA

only for absence seizures, inhibits T-type calcium channels

chlorpromazine indications and MOA

antipsychotic, block D2 receptor, notable ataxia

haloperidol indications and MOA

antipsychotic, block D2 receptor, notable ataxia

2 first gen antipsychotics on this list

chlorpromazine and haloperidol

3 second gen antipsychotics on this list

clozapine risperidone aripiprazole

first gen antipsychotic big side effects

extrapyramidals

second gen antipsychotic big side effects

diabeetus, hypercholesterolemia and weight gain

clozapine indications and MOA

second generation antipsychotic, indicated only for the most refractory of mothafuckas

bad effects of clozapine

bone marrow suppression, agranulocytosis, orthostasis, and seizures

risperidone indications and MOA

second generation antipsychotic

aripiprazole indications and MOA

second generation antipsychotic

adverse effects of barbiturates

addictive, drowsiness, nausea, vertigo, tremors

phenobarbital indications and MOA

sedation, GABA potentiation

short acting benzo from list

diazepam

medium acting benzo from list

alprazolam

cyclobenzaprine indications and MOA

muscle relaxant, centrally acting

alprazolam indications and MOA

intermediate acting benzo, potentiate GABA

diazepam indications and MOA

short acting benzo, potentiate GABA

benzo indications

anxiety reduction, sedative, hypnotic, anterograde amnesia, anticonvulsant, muscle relaxant

buspirone indications and MOA

chronic GAD, not helpful for event specific anxiety due to long action, fewer CNS depression side effects, but has greater nausea. potentiates serotonin and dopamine

zolpidem indications

hypnotic, no anticonvulsant or muscle relaxant properties. does not alter sleep stages like benzos

ramelteon indications and MOA

sleeps, melatonin agonist

baclofen indications

back-lofen, muscle relaxant acts on GABA receptors in spinal cord

ergotamine indications

early onset migraine headaches

ondansetron indications

antiemetic, especially during chemotherapy

carbamazepines favorite seizure

complex partial

first line for lots of seizures

phenytoin

pro-drug converted by liver into morphine

codeine

keep therapeutic levels of this for status epilep.

phenytoin

benzos are class

Pharm 2 Flashcards

(55 cards)