Pharm 2 Exam 3 Flashcards
(84 cards)
Diphenhydramine
Indication: Allergic RXN(Urticaria and Rhinitis), Motion sickness, Sleep Aid, and local Anesthetic
Contraindications:
MOA: Selective for H1, Antagonist
Adverse: Sedation, Anti-M effects, Excitation and convulsions in children, and orthostatic hypotension
Notes: PO, Penetrates CNS, and metabolized by Liver
Fexofenadine
Indication: Allergic RXN(Urticaria and Rhinitis), Motion sickness, Sleep Aid, and local Anesthetics.
MOA: Selective for H1 Antagonist
Adverse: Multiple metabolites, terfenadine can cause arrhythmias
Notes: Oral
Loratidine
Indication: Allergic RXN(Urticaria and Rhinitis), Motion sickness, Sleep Aid, and local Anesthetics.
MOA: Selective for H1 Antagonist
Adverse: Multiple metabolites, Decloratdaine
Notes: Oral
Ergotamine
Indication: Migraines and Postpartum hemorrhage
Contraindications:
MOA: Unclear but possible vasoconstriction
Adverse: NVD, and Vasospasm could lead to Gangrene and Amputation
Notes: last resort of postpartum
Bradykinin
Indication: Vasodilator Peptides
Contraindications:
MOA: B1 and B2 are Gq and Gs and B2 is the most responsive and metabolized by ACE
Adverse: Stimulate pain, hypotension, and inflammation
Notes: Direct and indirect effects(NO and PGI)
Dihydroergotamine
Indication: Abortive Migraine TX
Contraindications: Pregnant Women, and not for patients with PVD
MOA: Agonist for 5TH1 Receptor leads to constricted arteries
Adverse:
Notes: Most effective w/ an acute attack, used with sedative and anti-anxiety, and antiemetics
Sumatriptan
Indication: Abortive migraine, direct vasoconstrictor effect(NOT ANALGESIC)
Contraindications: PVD, CAD, DM, and Prego
MOA: Highly selective agonist for 5HT1D in the Intracranial vessels
Adverse:
Notes: Can combine with an analgesic for pain, ASA, APAP, Ibuprofen
Verapamil
Indication: Cluster HA
Contraindications:
MOA: CCB
Adverse:
Notes:
Litium
Indication: Cluster HA
Contraindications:
MOA:
Adverse:
Notes: Can Also tx bipolar
Indomethacin
Indication: Reduces Pain and inflammation
Contraindications:
MOA: COX inhibitor
Adverse: GI issues
Notes: Not a great COX inhibitor, worst do not use
Ibuprofen
Indication:
Contraindications: a
MOA: a
Adverse: a
Notes: Best Side effect profile
Acetaminophen
Indication: Pain
Contraindications:
MOA: Reversible Cox2 inhibitor
Adverse:
Notes: Not for anti-inflammatory, hepatotoxic w/ ETOH
Aspirin
Indication: Good anti-inflammatory, analgesic, antipyretic, and best for anti-platelet
Contraindications:
MOA: Irreversible COX1 and 2 inhibitors
Adverse:
Notes:
Celecoxib
Indication: Reversible COX-2 Inhibitor
Contraindications:
MOA: COX-1 helps with GI protection(TXA2 synth in PLTs) and COX-2 helps with prostacyclin synth
Adverse: GI isses main
Notes:
Colchicine
Indication: Used for Acute gout attack and prophylaxis
Contraindications:
MOA: Inhibits microtubule fxn which prevents migration and phagocytosis. Inhibits Leukotriene B4 synth
Adverse: NVD abd ABD pain
Notes:
Probenecid
Indication: Gout
Contraindications: a
MOA: Block active re-absorption of filtered urate in kidney. Hydrate to prevent formation of kidney stones & alkalinize urine
Adverse: Can aggravate acute gouty attack. Can cause GI irritation
Notes:
Sulfinpyrazone
Indication: Gout
Contraindications: a
MOA: Block active re-absorption of filtered urate in kidney. Hydrate to prevent formation of kidney stones & alkalinize urine
Adverse: Can aggravate acute gouty attack. Can cause GI irritation
Notes:
Allopurinol
Indication: Gout
Contraindications:
MOA: Inhibits urate synthesis by blocking xanthine oxidase
Adverse: a- GI irritation,Vasculitis, Bone marrow depression, Hypersensitivity reactions
Can precipitate acute gouty attack
Notes:
Rarburicase
Indication: Useful as adjunct during cancer chemotherapy , gout
Contraindications: a
MOA: Converts urate to allantoin
Adverse: Hypersensitivity and GI
Notes:
Fluticasone
Indication: Immunosuppression, Inflammatory states. RA, reduced pain, restorative for Asthma, Dermatological conditions and some CA
Contraindications:
MOA: Sympathetic stimulation,
Adverse: Susceptible to infections(immunosuppressed, Hyperglycemia(Endo), Osteoporosis, CNS: HTN, Stress
Notes:
Prednisone
Indication: Immunosuppression, Inflammatory states. RA, reduced pain, restorative for Asthma, Dermatological conditions and some CA
Contraindications:
MOA: Sympathetic stimulation,
Adverse: Susceptible to infections(immunosuppressed, Hyperglycemia(Endo), Osteoporosis, CNS: HTN, Stress
Notes: Oral for Servere asthma
Zileuton
Indication: Asthma
Contraindications:
MOA: Inhibits 5-lipoxygenase
Adverse: URI, Sore throat, HA, Sleepiness, psych symptoms
Notes: Decrease ASA sensitivity
Montelukast
Indication: Asthma
Contraindications:
MOA: Leukotriene receptor antagonist
Adverse: URI, Sore throat, HA, Sleepiness, psych symptoms
Notes: Decrease ASA sensitivity
Omalizumab
Indication: Moderate to severe ALLERGIC asthma
Contraindications:
MOA: Antibody for I-gE
Adverse: Rash, Injection site run, small decrease in plts
Notes: