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Flashcards in Pharm 20 Deck (88)
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1

Positive sxs

Hallucinations
Agitation
Disordered thinking

2

Negative sxs

Flat affect
Avolition
Social withdrawal
Impoverished

3

Cognitive sxs

Attention
Memory
Reasoning
Learning

4

Dopamine - 1 receptor blockade characteristics

Cardiovascular receptors

No correlation/ therapeutic effects on dosage of drugs

Mostly all ASEs

5

Dopamine -2 receptor blockade characteristics

- Receptors in mesolimbic mesocortical pathway

Produce "typical" effects, alleviate some positive sxs of schizophrenia.

D2 receptor binding correlates with clinical dosage of drugs to control schizophrenia

6

ASEs for D2 receptor blockage

Hyperprolactinemia
Amenorrhea-galactorrhea
Infertility and/or impotence
Parkinsonism
Akathisia
Dystonia
Tardive dyskinesia

7

Histamine-1 (H1)-receptor blockade characteristics

Blockage of H1 may be important to efficacy but many mediate ASEs of these drugs.

Therapeutic benefit is unknown

8

Histamine-1 (H1)-receptor blockade ASEs

Weight gain

Sedation

9

5-Hydroxytryptamine-2A (5-HT2A)-receptor blockade characteristics

May contribute to the efficacy of antipsychotics

May improve some negative sxs of schizophrenia

10

5-Hydroxytryptamine-2A (5-HT2A)-receptor blockade ASEs

weight gain

11

Muscarinic-1 (M1)-receptor blockade characteristics

May reduce manifestations of movement disorders but NOT the underlying pathology of the movement disorder

May mask the development of movement disorder

12

Muscarinic-1 (M1)-receptor blockade ASEs

Loss of accommodation
Dry mouth
Difficulty urinating
Constipation
Delirium

13

Alpha-1 (α1)-adrenoceptor blockade characteristics

May provide benefit in pts with mixed psychotic illness, partially PTSD and/or in pts with nightmares

14

Alpha-1 (α1)-adrenoceptor blockade ASEs

Orthostatic Hypotension
Impotence
Ejaculatory disorders

15

Norepinephrine (NE) reuptake inhibition characteristics

Antidepressant effects
Reduced potential for weight gain

16

Norepinephrine (NE) reuptake inhibition ASEs

Agitation

17

Typical antipsychotic agents vs. atypical antipsychotics.

All antipsychotics are fairly effective at treating the positives symptoms.

The newer atypcal agents are more likely to alleviate some of the more negative symptoms.

18

Typical antipsychotic characteristics

They are D2 antagonist

19

Typical antipsychotic ASEs

Extrapyramidal toxicity
Tardive dyskinesia
Hyperprolactinemia-sexual dysfunction

20

Atypical antipsychotic characteristics

5HT2A/D2 antagonist

Reduced potential for extrapyramidal tox and hyperlactatemia

21

Atypical antipsychotic ASEs

Metabolic effects:
Weight gain
Worsening of lipid profile
Increased risk for DM and CV disease.

22

Group 1 atypical MC ASE

higher risk for metabolic effects

23

Group 2 atypical MC ASE

can still cause weight gain but lower risk compared to group 1

24

Extrapyramidal S/S

Dystonia
Akathisia
Parkinsonism

25

Extrapyramidal time of onset

Can occur at anytime of treatment

26

Extrapyramidal Tx

Antimuscarinic drug started ASAP (Benztropine), d/c any anticholinergic drugs

27

Movement disorders caused by direct dopamine receptor blockade

Parkinsonism
Akathisia
Dystonia

28

Movement disorders caused by dopamine receptor hypersensitivity

Tardive dyskinesia

29

3 specific txs have been approved to tx depressive phase in bipolar disorder

Quetiapine extended release
Olanzapine/fluoxetine
Lurasidone

30

Explain how renal clearance is effected by lithium

Renal clearance of lithium is reduced by diuretics, NSAID, ACE inhibitors, and ARBS