Pharm

Question 1

What is the equation for Volume of distribution?

Answer 1

Vd = amount of drug in body/plasma drug concentration

Question 2

What is the equation for half-life?

Answer 2

t 1/2 = (0.693 x Vd) / CL

Question 3

What is the equation fro clearance?

Answer 3

CL = rate of elim/ plasma drug conc = Vd x Ke

Question 4

What is the equation for loading dose?

Answer 4

Loading dose = (Cp x Vd) / F

Question 5

What is the equation for maintenance dose?

Answer 5

Maintenance dose = (Cp x CL x tau) / F = Css x CL

Question 6

What drugs cause coronary vasospasm?

Answer 6

Cocaine, sumatriptan, ergot alkaloids, amphetamines

Question 7

What drugs cause cutaneous flushing?

Answer 7

VANC: Vancomycin, Adenosine, Niacin, Calcium channel blockers

Question 8

What drugs cause dilated cardiomyopathy?

Answer 8

Doxorubicin, daunorubicin

Question 9

What drugs cause Torsades de pointes?

Answer 9

Class III and class IA antiarrhythmics, macrolide antibiotics, antipsychotics, TCAs, antimalarial

Question 10

What drugs cause hot flashes?

Answer 10

Tamoxifen, clomiphene

Question 11

What drugs cause Hypothyroidism?

Answer 11

Lithium, Amiodarone, Sulfonamides

Question 12

What drugs cause hypoglycemia?

Answer 12

Tacrolimus, Protease inhibitors, Niacin, HCTZ, B-blockers, Corticosteroids (Taking Pills Necessitates Having Blood Checked)

Question 13

What drugs cause gynecomastia?

Answer 13

Spironolactone, Ketoconazole, estrogens, cimetidine, alcohol, marijuana

Question 14

What drugs cause acute cholestatic hepatitis, jaundince?

Answer 14

Erythromicin

Question 15

What drugs cause diarrhea?

Answer 15

Metformin, Erythromycin, Colchicine, Orlistat, Acarbose (Might Excite Colon On Accident)

Question 16

What drugs cause Focal to massive hepatic necrosis?

Answer 16

Halothane, Amanita phalloides, Valproic acid, Acetaminophen (Liver “HAVAc”)

Question 17

What drug can cause hepatitis?

Answer 17

INH

Question 18

What drugs can cause pancreatitis?

Answer 18

Didanosine, Corticosteroids, Alcohol, Valproic acid, Azathioprine, Diuretics (Drugs Causing A Violent Abdominal Distress)

Question 19

What drugs cause agranulocytosis?

Answer 19

Dapsone, Clozapine, Carbamazepine, Colchicine, Methimazole, Propylthiouracil (Drugs CCCrush Myeloblasts and Promyelocytes)

Question 20

Waht drugs cause Aplastic anemia?

Answer 20

Carbamazepine, Methimazole, NSAIDs, Benzene, Chloramphenicol, Propyltiouracil (Can’t Make New Blood Cells Properly)

Question 21

What drugs cause Direct Coombs-positive hemolytic anemia?

Answer 21

Methyldopa, penicillin

Question 22

What drugs causes gray baby syndrome?

Answer 22

Chloramphenicol

Question 23

What drugs cause hemolysis in G6PD deficiency?

Answer 23

INH, Sulfonamides, Dapsone, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin & Fava beans (Hemolysis IS D PAIN)

Question 24

What drugs cause Megaloblastic Anemia?

Answer 24

Phenytoin, Methotrexate, Sulfa drugs (Having a blast with PMS)

Question 25

What drugs can cause thrombocytopenia?

Answer 25

Heparin, cimetidine

Question 26

What drugs can cause fat redistributions?

Answer 26

Protease inhibitors, Glucocorticoids (Fat PiG)

Question 27

What drugs cause gingival hyperplasia?

Answer 27

Phenytoin, verapamil, cyclosporine, nifedipine

Question 28

What drugs cause Hyperuricemia?

Answer 28

Pyrazinamide, Thiazides, Furosemide, Niacin, Cyclosporine (Painful Tophi and Feet Need Care)

Question 29

What drugs can cause myopathy?

Answer 29

Fibrates, niacin, colchicine, hydroxychloroquine, interferon-a, penicillamine, statins, glucocorticoids

Question 30

What drugs cause osteoporosis?

Answer 30

Corticosteroids, heparin

Question 31

What drugs cause photosensitivity?

Answer 31

Sulfonamides, Amiodarone, Tetracyclines, 5-FU (SAT For Photo)

Question 32

What drugs cause rash?

Answer 32

Anti-epileptic drugs, allopurinol, sulfa drugs, penicillin

Question 33

What drugs cause SLE-like syndrome?

Answer 33

Sulfa drugs, Hydralazine, INH, Procainaminde, Phenytoin, Etanercept (Having lupus is "SHIPP-E")

Question 34

What drugs cause teeth discoloration

Answer 34

Tetracyclines

Question 35

What drugs cause tendonitis, tendon rupture, and cartilage damage?

Answer 35

Fluoroquinolones

Question 36

What drugs cause cinchonism?

Answer 36

Quinidine, quinine

Question 37

What drugs cause Parkinson-like syndrome?

Answer 37

Antipsychotics, Reserpine, Metoclopramide (Cogwheel rigidity of ARM)

Question 38

What drugs can cause seizures?

Answer 38

INH, Bupropion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide (With seizures, I BITE My tongue

Question 39

What drugs cause tardive dyskinesia?

Answer 39

Antipsychotics, metoclopramide

Question 40

What drugs cause Diabetes insipidus?

Answer 40

Lithium, demeclocycline

Question 41

What drugs cause Fanconi syndrome?

Answer 41

Expired tetracycline (proximal tube defect)

Question 42

What drugs cause hemorrhagic cystitis?

Answer 42

Cyclophosphamide, ifosfamide (Prevent with Mesna)

Question 43

What drugs cause interstitial nephritis?

Answer 43

Methicillin (and other Abx), NSAIDs, and Furosemide

Question 44

What drugs can cause SIADH?

Answer 44

Carbamazepine, Cyclophosphamide, SSRIs (Can't Concentrate Serum Sodium)

Question 45

What drugs cause a dry cough?

Answer 45

ACE inhibitors

Question 46

What drugs cause pulmonary fibrosis?

Answer 46

Bleomycin, Amiodarone, Busulfan, Methotrexate

Question 47

What drugs have antimuscarinic side effects?

Answer 47

Atropine, TCAs, H1-blockers, antipsychotics

Question 48

What drugs have a disulfiram-like reaction?

Answer 48

Metronidazole, certain Cephalosporins, Griseofulvin, Procarbazine, 1st-gen sulfonylureas

Question 49

What drugs have nephrotoxicity/ototoxicity?

Answer 49

Aminoglycosides, vancomycin, loop diuretics, cisplatin