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Flashcards in Pharm 25 Drug List Deck (55)
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1

List the Alkylating Agents: Nitrogen Mustard drugs

Cyclophosphamide
Ifosfamide

2

Cyclophosphamide and Ifosfamide unique ASEs?

Hemorrhagic cystitis

CNS toxicity - confusion, AMS, encephalopathy

3

Why is Mesna used in conjunction with Ifosfamide?

Binds to acrolein to prevent hemorrhagic cystitis

4

List the Alkylating Agents: Platinum Analogues drugs

1. Carboplatin
2. Cisplatin
3. Oxaliplatin

5

ASEs of Platinum Analogue: Carboplatin?

Myelosuppression - thrombocytopenia

6

ASEs of Platinum Analogue: Cisplatin?

Ototoxicity

Highly emetic: acute (18-24hrs post tx) and delayed (48-72 hrs post tx)

Nephrotoxicity

7

ASEs of Platinum Analogue: Oxaliplatin?

Cold sensitivity - pharygolaryngeal dysethesia

Peripheral neuropathy

8

List the Topoisomerase Enzyme Inhibitor drugs

1. Irinotecan
2. Doxorubicin
3. Etoposide

9

List the Topoisomerase Enzyme Inhibitor: Camptothecins drug

Irinotecan

10

List the Topoisomerase Enzyme Inhibitor: Anthracycline drug

Doxorubicin

11

List the Topoisomerase Enzyme Inhibitor: Epipodophyllotoxin drug

Etoposide

12

ASEs of Camptothecins: Irinotecan?

When taking Irinotecan pts with UGT1A1 allele can experience life threatening diarrhea

Hepatic impairment

Neutropenia (UGT1A1 28)

13

What adjunct therapies do you use to avoid both acute and delayed diarrhea when taking Irinotecan?

Acute: use atropine

Delayed: use loperamide

14

ASEs of Anthracycline: Doxorubicin?

Cardiotoxicity (dilated cardiomyopathy)

Urine discoloration

15

What medication is often given with Doxorubicin to reduce cardiotoxicity?

Dexrazoxane

16

MOA of Dexrazoxane + Doxorubicin?

Inhibits free radical formation ---> limiting cardiotoxicity

17

What potential ASE occurs with using Dexrazoxane + Doxorubicin?

Potential decreases the chemo drug effectiveness.

18

ASEs of Epipodophyllotoxin: Etoposide?

Infection related rxn: HypoTN, fever/chills

Hypersensitivity rx: Anaphylaxis, tachy, bronchospasm, dyspnea

19

List the Antimicrotubule drugs

1. Vincristine
2. Docetaxel
3. Paclitaxel

20

List the Antimicrotubules: Vinca Alkaloid drug

Vincristine

21

List the Antimicrotubules: Taxanes drugs

Docetaxel
Paclitaxel

22

ASEs of Vinca Alkaloid: Vincristine?

Neurotoxicity: sensor, motor, peripheral neuropathy

Fatal if administered intrathecally - irreversible

23

What is best practice to avoid causing fatality when administering Vincristine?

Use IV mini infusion bags not syringes

24

ASES of Taxanes: Docetaxel
and Paclitaxel?

Cardiovascular - peripheral edema, flushing

Neurotoxic- cumulative peripheral neuropathy

25

List the Antimetabolites

1. Capecitabine
2. Fluorouracil (5-FU)
3. Cytarabine
4. Methotrexate (MTX)

26

List the Antimetabolites: Pyrimidine Analogue dugs

1. Capecitabine
2. Fluorouracil (5-FU)
3. Cytarabine

27

ASEs of Pyrimidine Analogues: Capecitabine and Fluorouracil (5-FU)

Continuous infusion:
- Mucosal damage
- Palmar - plantar erythrodysesthia ("hand-foot syndrome")

Genetic polymorphism defect (DPD)

28

List the Antimetabolites: Antifolate drug

Methotrexate (MTX)

29

ASEs of Antifolate: Methotrexate (MTX)

Mucosal damage

Hepatotoxicity and Nephrotoxicity

30

What are 2 drug interactions with Methotrexate (MTX)?

- NSAIDs (decreased clearance of MRX --> increased toxicity)

- PPIs (elevate and prolong serum MTX levels (high dose MTX)