Pharm

Question 1

Cyclophosphamide- Indications

Answer 1

Breast cancer, lymphoma and leukemia

Question 2

Cyclophosphamide- MOA

Answer 2

Alkylating agent- nitrogen mustard representative drug, Cell cycle nonspecific- decreases DNA synthesis

Question 3

Cyclophosphamide-AE

Answer 3

Hemorrhagic cystitis (Mesna to prevent), cardiotoxicity, myelosupression

Question 4

Cisplatin- Indications

Answer 4

Solid tumors

Question 5

Cisplatin- MOA

Answer 5

Alkylating agent. Non-specific. Platinum compound representative. Interferes with DNA inter strand crosslinks

Question 6

Cisplatin- AE

Answer 6

Renal & ototoxicity, hypersensativity rxn, severe N/V

Question 7

Methotrexate- Indications

Answer 7

ALL, breast, head & neck, Non-hodgkin, osteo.

Question 8

Methotrexate- MOA

Answer 8

Antimetabolite- Folate antagonist- cell cycle specific. Binds to enzymes blocking DNA synthesis, repair and cellular replication

Question 9

Methotrexate- AE

Answer 9

Kidney injury, mucositis, elevated LFTs, rash. Interactions with NSAID, penicillin, PPI

Question 10

Fluorouracil- Indications

Answer 10

Breast, colon & gastric CA

Question 11

Fluorouracil- MOA

Answer 11

Antimetabolite- cell cycle specific- pyrmidine analogue- Interferes with DNA & RNA synthesis due to lack of thymidine

Question 12

Fluorouracil- AE

Answer 12

stomatitis, GI ulcer, Hand & foot syndrome, cardiotoxicity-angina

Question 13

Anastrazole- MOA

Answer 13

Aromatase inhibitor- Hormonal agent- Non-specific- interferes with estradiol production in peripheral tissues- inhibits conversion of adrenally generated androstenedione

Question 14

Anastrazole- Indications

Answer 14

Post menopausal breast cancer

Question 15

Anastrazole- AE

Answer 15

Cardiovascular, flushing, metabolic disturbances

Question 16

Vincristine- Indications

Answer 16

ALL, CNS tumors, Hodgkin, NHL

Question 17

Vincristine- MOA

Answer 17

Vinca alkyloid- cell cycle specific- antimicrotubule- Binds to tubulin inhibiting microtubule formation- cell arrested at metaphase

Question 18

Vincristine- AE

Answer 18

Constipation, neurotoxicity, cranial nerve disorder, phlebitis & cellulits. Death with intrathecal admin!

Question 19

Paclitaxel- MOA

Answer 19

Antimicrotubule- cell cycle specific- G2/ M phase- Bind to tubulin leading to nonfunctional microtubles- chromosome desegregation does not occur

Question 20

Paclitaxel- AE

Answer 20

Neutropenia, peripheral neuropathy, bradycardia

Question 21

Irinotecan- Indications

Answer 21

Colon & rectal carcinoma

Question 22

Irinotecan- MOA

Answer 22

Topoisomerase 1 inhibitor- cell cycle specific- prevents religation of single strand DNA breaks

Question 23

Irinotecan- AE

Answer 23

myelosupression, neutropenia, diarrhea

Question 24

Imatanib- Indications

Answer 24

CML, GI stromal tumors

Question 25

Imatanib- MOA

Answer 25

Targeted therapy. Inhibits tyrosine kinase- blocks proliferation, platelet growth factor, stem cell growth factor, induces apoptosis.

Question 26

Imatanib- AE

Answer 26

Edema, fluid retention, hepatotoxicity, thrombocytopenia, neutropenia

Question 27

Doxorubicin- Indications

Answer 27

Breast, metastatic, leukemia & lymphoma

Question 28

Doxorubicin- MOA

Answer 28

Anthracycline- cell cycle specific- Inhibits topoisomerase II, iron chelator binds to cell membrane and produces free radicals to cleave DNA.

Question 29

Doxorubicin- AE

Answer 29

Cardiotoxicity, secondary malignancies (heme), extravasation, hepatic fxn

Question 30

Etoposide- MOA

Answer 30

Topoisomerase II inhibitor, binds to topo II and causes DNA strand cell break. Cell cycle specific

Question 31

Etoposide- AE

Answer 31

Inflamed mucous membranes, secondary malignancies, hepatotoxicity, diarrhea

Question 32

Paclitaxel- MOA

Answer 32

Antimicrotubule/ mitotic inhibitor, cell cycle specific, prevents chromosome separation

Question 33

Paclitaxel- AE

Answer 33

Neutropenia, peripheral neuropathy, bradycardia

Question 34

Tamoxifen- Indications

Answer 34

Breast CA

Question 35

Tamoxifen- MOA

Answer 35

Hormone therapy, cell cycle non-specific- Non steroidal anti-estrogen, Binds to estrogen receptor to prevent growth. Only works on estrogen receptor positive

Question 36

Tamoxifen- AE

Answer 36

Flushing, thromboembolic events, uterine CA

Question 37

Leuprolide- Indications

Answer 37

Prostate & brest CA

Question 38

Leuprolide- MOA

Answer 38

Hormal therapy, cell cycle non-specific. Inhibit gonadatropin secretion or action- surpasses effects of steroid genesis due to decreased LSH, FSH.

Question 39

Bevacizumab- Indications

Answer 39

Antiangiogenesis- cuts off blood supply to tumors. Metastatic colorectal CA

Question 40

Bevacizumab- MOA

Answer 40

Monoclonal antibody, immunotherapy- cell cycle nonspecific. Attaches to vascular endothelial GF- blocks stimulation of new blood vessels

Question 41

Bevacizumab- AE

Answer 41

HTN, stomatitis, blood, protein in urine, GI bleed, bowel perforation, stroke

Question 42

Interferon alpha- Indications

Answer 42

Hematologic & solid tumors

Question 43

Interferon alpha- MOA

Answer 43

Biologic response modifier- immunotherapy- suppress cell proliferation, activate macrophages, increased cytotoxicity of lymphocytes

Question 44

Interferon alpha- AE

Answer 44

Flu like symptoms, N/V/D, skin rash, bleeding, hypotension