Pharm

Question 1

roundworm, hookworm tx

Answer 1

albendazole, pyrantel pamoate or mebendazole

Question 2

threadworm tx

Answer 2

ivermectin

Question 3

pinworm tx

Answer 3

pyrantel pamoate or mebendazole

Question 4

trichinosis tx

Answer 4

mebendazole or albendazole. steroids added if severe infection

Question 5

whipworm tx

Answer 5

mebendazole or albendazole

Question 6

trichostrogylus tx

Answer 6

pyrantel pamoate or mebendazole

Question 7

cutaneous larva migrans tx

Answer 7

albendazole or ivermectin

Question 8

visceral larva migrans tx

Answer 8

albendazole

Question 9

angiostronylus cantonesis tx

Answer 9

mebendazole or albendazole

Question 10

filariasis tx

Answer 10

diethylcarbamazine

Question 11

onchocerciasis tx

Answer 11

ivermectin

Question 12

guinea worm tx

Answer 12

metronidazole

Question 13

bilharziasis, schistosoma mansoni, japonicum, liver fluke, lung fluke tx

Answer 13

praziquantel

Question 14

large or small intestinal fluke tx

Answer 14

praziquantel or niclosamide

Question 15

beef tapeworm, fish tapeworm, pork tapeworm tx

Answer 15

praziquantel or niclosamide

Question 16

pork tapeworm larval stage tx

Answer 16

albendazole, praziquantel (alt)

Question 17

dwarf tapeworm tx

Answer 17

praziquantel , nitazoxanide (alt)

Question 18

hydatid disease tx

Answer 18

albendazole

Question 19

oral drug bioavail improved by fatty meal

Answer 19

albendazole

Question 20

active sulfoxide metabolite produced in 1st pass metab

Answer 20

albendazole - dist well in body, CSF, hydatid cysts

Question 21

monitor blood counts and LFTS

Answer 21

albendazole- long term use

Question 22

no active metabolite, blood dyscrasia rare, but monitor CBCs and LFTs

Answer 22

mebendazole

Question 23

oral drug with good bioavail, increased by high carb meal or cimetidine, reduced by phenytoin or carbamazepine

Answer 23

pyrantel pamoate

Question 24

take with liquid after meal, don’t chew - bitter

Answer 24

praziquantel and pyrantel pamoate

Question 25

increases permeability of trematode or cestode membranes to calcium, resulting in paralysis

Answer 25

pyrantel pamoate

Question 26

AE N/V, diarrhea, abdominal pain and cramp, HA, dizz

Answer 26

pyrantel pamoate

Question 27

increases cell membrane permeability in susceptible worms- rapid contraction - vacuolization and disintegration of the schistosome tegument

Answer 27

praziquantel

Question 28

CYP3A4 interactions possible, malaise, HA, dizz, abd discomfort, nausea, fever, urticaria

Answer 28

praziquantel

Question 29

oral or topical, CYP2E1, 2D6, 3A4

Answer 29

ivermectin

Question 30

selective high affinity binding to glutamate-gated Cl- channels in invertebrate nerve and muscle cells

Answer 30

ivermectin

Question 31

usually produces fewer AE and better compliance

Answer 31

ivermectin

Question 32

not avail in US - oral, remains in GI tract, inhibits ox phos or stim ATPase activity

Answer 32

niclosamide

Question 33

inhibits arachidonic acid metab, making microfilaria more susceptible to immune attack

Answer 33

diethylcarbamazine - no longer approved in US

Question 34

kills symbiotic bacterium Wolbachia leading to death of worm (filarial)

Answer 34

doxycycline

Question 35

entamoeba histolytica tx

Answer 35

asym - paromomycin or iodoquinol. sym intestinal dz - metronidazole or tinidazole, followed by paromomycin or iodoquinol