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Pharm Flashcards

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1
Q

Amingoglycoside tox-

A

OTO, nephro, NMHJ block. Teratogenic

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2
Q

Linezolid - tx? Concern for?

A

VRE, VRSA,

Concern - serotonin syndrome.

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3
Q

Tetracycline concerns?

A

Photosenstiivity rash - teeth discoloration

Dont give in pregnant or children under 8y.o (doxy at least)

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4
Q

Macrolide tox?

A

Cholestatic hepatitis

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5
Q

Clinda tx?

A

Anaerobes, MRSA, Osteo (good bone concentration)

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6
Q

Fluoroquinodone concern?

A

Tendon

Also - Cipro tx pseudomonas

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7
Q

Metronidazole - mechanism of action

A

Free radical generation -

Tx anaerobes + a lot more .

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8
Q

TMP SMX - tox?

PPX for?

A

Anemia, G6PD trigger, SS trigger.

Tx - pseduo, nocardia,

PPX PCP, toxo, transplant

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9
Q

RIPE -

Side effects? for all? for one?

A

All have hepatotox

Pyrazidamine - Hyperuricemia

I know the others

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10
Q

Amphotericin tox?

Capsofung in Tox?

A

Neprhotox - HypoK, HypoMg

Caspofungin - Flushing, GI upset

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11
Q

Acyclovir,

Gangcylcovir

Foscarnet

tx?

A

ALL ARE NEPHROTOX.

Acyclovir - cystalline nephropathy (obsturctive)

Gangcylcovir - CMV - CYTOPENIA, renal tox

Foscarnet Used to tx CMV retinits - Nephrotox.

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12
Q

Maraviroc - Mech -

A

CCr5 - attachment block block gp120.

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13
Q

Enfuviritide - mech -

A

Enfuviritide - inbhits ENTRY - blocks gp41

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14
Q

RTI - nucleotide

RTI - nonnucleotide

Which? Tox?

A

RTI nucleotide - ZDV, lamivudine, Tenofovir, Didanosine, Abacavir - Bone marrow tox. LACTIC ACIDOSIS, NEUROPATHY.

RTI NONnucl- - Efavierenz, Nevirapine (1 shot at birth)m Delaverdine. LESS MARROW TOX. RASH, HEPATOTOX

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15
Q

Raltegravir - Mech - tox

A

Integrase inhibtor

Tx - Hypercholesterolemia

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16
Q

Navirs - Mech - Tox?

A

Protease inhbiitor. Hyperglycemia. Nephropathy.

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17
Q

Which anesthetic DEC IOP?

A

Thipental (barbitutatE) - DEC ICP.

Rapid entry into bain and redispribution.

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18
Q

Types of NM Blocker?

Depol

Nondepol

A

NM Blcoker - Nicotoninc motor receptor

Depol - Succ - Achr Agonist - Tox HyperK, HyperCa

  • Phase 1 - no antide
  • Phase 2 - cholinesterase inhbiitor

Nondepol - Turbocurare, mivacurium, RONIUMS. - Achr Competitive antagonists

Reversal - Neostigmine + Atropine (prevents muscarining side effects) `

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19
Q

Tox Tx.

Copper

Fe

Cyanide

Study These Flashcards
A

Copper - Penacillamine

FE - Deferoxamine

Cyanide - Nitrites + SUlfate + Hydroxy Cobalamin

20
Q

Tox tx

Lead

mercury

Study These Flashcards
A

Lead - EDTA, Dimercaprol

mercury - Dimercaptrol

21
Q

Tox tx

Heparin

TPA

Warfarin

Study These Flashcards
A

Heparin - protamin

TPA - aminocaproic

Warfarin - FFP + Vit K

22
Q

Tx Hyper!

K

Mg

TCA

Study These Flashcards
A

Hyper K - Ca gluconate

Hyper Mg - Ca gluconate

TCA poixoni - Sodium Bicarb

23
Q

Aspirin tox side effects.

ABG?

Study These Flashcards
A

Aspiriing - asthma, chronic rhinit,s polpyps

Tox tinnitus, fever

ABG - PH NORMA 7.4
Because Met acidosis (anion gap!) + resp alkalosis.

24
Q

ACE i tox?

Study These Flashcards
A

Cough, angioedema HYPERK!

25
Lead tox?
Abd pain, constipation, neuropathy, neprhopathy, neuropsych, mylagias, HTN
26
Zinc def causes?
Alopecia, DEC food tase, pustular skin lesions
27
VIT D tox - How to differentate from DKA?
HyperCa, polyuria, abd pain, UA IS NORMAL (abnormal in DKA)
28
Vit A tox -
dry skin, blurry vison, pseudotumor
29
Primidone tox can cause?
Acute intermitten porphyria - abd pain, hallucinatiosn
30
Transplant pt ppx?
Bactrim for PCP
31
Benzo tox presentation?
MAY NOT HAVE PUPILLARY OCNSTRICTION - Slurred speech, no severe resp distress.
32
Megestrol acetate - mech - for?
Progesteron - use for cachexia in CA pt. Cannabis does not work.
33
Tx for Lyme in Pregnancy?
Amoxicillin
34
EPO side effect Therapeutic EPO concern?
HTN!! headache,. If you are therapeutically given EPO, must give Iron to prevent iron deficiency.
35
Drug induced esophagitis
KCl, Tertracylcine, NSAID, Alendronate, Fe
36
PPI/H2 blocker increases risk for?
C diff
37
Cocaine preventative measure? Pharmacotherapy?
No pharm. 12 step and psychotherapy. Cocaine anonymous
38
Phenytoin tox - 3 major signs
horizontal nystagmus, cerebellar ataxia, confusion
39
Lithium tox
tremor, hyperreflexia, ataxia, seizures.
40
Cylophosphamide tox
hemorrhagic cystitis + BLADDER CA.
41
Which immunosuppressant gives you cochlear dysfunction?
Cisplatin carboplatin (amifostine)
42
Warfarin bleed give?
Vit K + Prothrombin complex concentrate (vit K clotting factors with RAPId reversal), Can give FFP if PCC not available.
43
Terbinafine, fluconazole tox
– hepatotox . Amphotericin is the one with neprhotox
44
Kaposi tx in those reftractior to antiretrovirals?
Adiramycin and vinblastine
45
Aspirin tox can give
– Bicarb to alk urine.
46
Benzo tox in ED tx
– let them sleep. Flumazenil can precipitate withdrawal seizures.

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