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Pharm Flashcards

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1
Q

Phenelzine

  • brand name
  • drug type / mech of action
  • advantages/uses
  • disadvantages/side effects
A

brand name: (Nardil)

type/mech: MAO Inhibitor –> less metabolism of 5HT, NE, DA

  • advantages/uses: depression
  • disadvantages/side effects: serotonin syndrome, hypertensive crisis w/ tyramines
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2
Q

Tranylcypromine

  • brand name
  • drug type / mech of action
  • advantages/uses
  • disadvantages/side effects
A

brand name: (Parnate)

type/mech: MAO Inhibitor –> less metabolism of 5HT, NE, DA

  • advantages/uses: amphetamine-like properties
  • disadvantages/side effects: serotonin syndrome, hypertensive crisis w/ tyramines
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3
Q

Isocarboxazid

  • brand name
  • drug type / mech of action
  • advantages/uses
  • disadvantages/side effects
A

brand name: (Marplan)

type/mech: MAO Inhibitor –> less metabolism of 5HT, NE, DA

  • advantages/uses: depression
  • disadvantages/side effects: serotonin syndrome, hypertensive crisis w/ tyramines
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4
Q

Selegiline

  • drug type / mech of action
  • advantages/uses
  • disadvantages/side effects
A

type/mech: MAO-B Inhibitor –> less metabolism of 5HT, NE, DA

  • advantages/uses: parkinsons, transdermal available
  • disadvantages/side effects: serotonin syndrome, hypertensive crisis w/ tyramines
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5
Q

What are common and dangerous side effects of MAO Inhibitors?

A

common: GI distress, orthostasis hypotension, sleep disturbance, dry mouth, headache
dangerous: serotonin syndrome (flushing, diaphoresis, myoclonic jerks) and hypertensive crisis (w/ tyramine)

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6
Q

Nortriptyline

  • brand name
  • drug type / mech of action
  • advantages/uses
  • disadvantages/side effects
A
  • brand name: pamelor
  • drug type / mech of action: TCA, inhibits 5HT and NE reuptake
  • advantages/uses: least likely to cause orthostasis
  • disadvantages/side effects: lots of side effects, lethal in overdose
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7
Q

Desipramine

  • brand name
  • drug type / mech of action
  • advantages/uses
  • disadvantages/side effects
A
  • brand name: norpramin
  • drug type / mech of action: TCA, inhibits 5HT and NE reuptake
  • advantages/uses: lest sedating, fewer anticholinergic SEs
  • disadvantages/side effects: lots of side effects, lethal in overdose
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8
Q

Clomipramine

  • brand name
  • drug type / mech of action
  • advantages/uses
  • disadvantages/side effects
A
  • brand name: anafranil
  • drug type / mech of action: TCA, inhibits 5HT and NE reuptake
  • advantages/uses: most 5HT specific, use to treat OCD
  • disadvantages/side effects: lots of side effects, lethal in overdose
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9
Q

Amitryptiline

  • brand name
  • drug type / mech of action
  • advantages/uses
  • disadvantages/side effects
A
  • brand name: elavil
  • drug type / mech of action: TCA, inhibits 5HT and NE reuptake
  • advantages/uses: use to treat chronic pain, headaches, neuropathy
  • disadvantages/side effects: lots of side effects, lethal in overdose
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10
Q

Which TCAs can be used to treat chronic pain or neuropathy?

A

imipramine, amitryptyline (elavil), doxepin

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11
Q

What are the common and dangerous side effects of TCAs?

A

common:

  • anti-Histamine: sedation
  • anti-adrenergic: orthostatic hypotension, tachy, arrhythmia
  • anti-muscarinic: dry mouth, constipation, urine retention, blurred vision, tachycardia
  • weight gain

dangerous: contraindicated if pre-existing cardiac conduction abnormalities, lethal in overdose –> wide QRS –> torsades –> Vfib

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12
Q

What is treatment for TCA overdose?

A

sodium bicarb and magnesium to stabilize arrythmia

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13
Q

Fluoxetine

  • brand name
  • drug type / mech of action
  • advantages/uses
  • disadvantages/side effects
A
  • brand name: prozac
  • drug type / mech of action: SSRI
  • advantages/uses: activating, long half life (no need to taper, use in pts with variable compliance), depression
  • disadvantages/side effects: most side effects (esp. sex dysfunction), can worsen anxiety
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14
Q

Paroxetine

  • brand name
  • drug type / mech of action
  • advantages/uses
  • disadvantages/side effects
A
  • brand name: paxil
  • drug type / mech of action: SSRI
  • advantages/uses: sedating, use in anxiety disorders, depression
  • disadvantages/side effects: short half life –> can cause discontinuation syndrome, cannot miss doses
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15
Q

Sertraline

  • brand name
  • drug type / mech of action
  • advantages/uses
  • disadvantages/side effects
A
  • brand name: zoloft
  • drug type / mech of action: SSRI
  • advantages/uses: few drug drug interactions, use in medically ill and elderly, anxiety disorders, depression
  • disadvantages/side effects: causes GI upset esp. at start, shorter half life can lead to discontinuation syndrome
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16
Q

Citalopram/Escitalopram

  • brand name
  • drug type / mech of action
  • advantages/uses
  • disadvantages/side effects
A
  • brand name: celexa / lexapro
  • drug type / mech of action: SSRI
  • advantages/uses: few drug-drug interactions, low side effects, go-to drug for depression
  • disadvantages/side effects: dose limited to 40mg adults, 20mg geri due to long QT (citalopram only)
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17
Q

Fluvoxamine

  • brand name
  • drug type / mech of action
  • advantages/uses
  • disadvantages/side effects
A
  • brand name: luvox
  • drug type / mech of action: SSRI
  • advantages/uses: only approved for OCD and social anxiety disorder (not depression)
  • disadvantages/side effects: BID dosing, p450 interactions, short half life can lead to discontinuation syndrome
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18
Q

Venlafaxine

  • brand name
  • drug type / mech of action
  • advantages/uses
  • disadvantages/side effects
A
  • brand name: effexor
  • drug type / mech of action: SNRI
  • advantages/uses: can help with chronic pain
  • disadvantages/side effects: contraindicated in pts with poorly controlled HTN; short half life, withdrawal syndrome
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19
Q

Duloxetine

  • brand name
  • drug type / mech of action
  • advantages/uses
  • disadvantages/side effects
A
  • brand name: cymbalta
  • drug type / mech of action: SNRI
  • advantages/uses: can help with chronic pain
  • disadvantages/side effects: very expensive, can cause nausea
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20
Q

What are common side effects of SSRIs?

A

sex dysfunction, GI upset, headache

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21
Q

What are common side effects of SNRIs?

A

sex dysfunction, GI upset, headache, more activating than SSRIs

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22
Q

Buproprion

  • brand name
  • drug type / mech of action
  • advantages/uses
  • disadvantages/side effects
A
  • brand name: wellbutrin
  • drug type / mech of action: inhibits reuptake NE and DA
  • advantages/uses: rare to have sex side effects, relatively activating, helpful in smoking cessation
  • disadvantages/side effects:
    similar SE to SSRI (GI upset, headache), rarely sexual side effects
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23
Q

Mirtazapine

  • brand name
  • drug type / mech of action
  • advantages/uses
  • disadvantages/side effects
A
  • brand name: remeron
  • drug type / mech of action: 5Ht2a/c, 5Ht3a antagonist
  • advantages/uses: useful in pts with poor appetite, useful as sleep aid at low dose
  • disadvantages/side effects: sedates at low dose, appetite stimulation –> can lead to weight gain
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24
Q

Haloperidol

  • brand name
  • drug type / mech of action
  • advantages/uses
  • disadvantages/side effects
A
  • brand name: haldol
  • drug type / mech of action: 1st gen antipsychotic, D2 blockade
  • advantages/uses: high efficacy, fewer anti-ACh SEs, short acting injectable available, long acting decanoate
  • disadvantages/side effects: high incidence of EPS
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25
Fluphenazine - brand name - drug type / mech of action - advantages/uses - disadvantages/side effects
- brand name: prolixin - drug type / mech of action: 1st gen antipsychotic, D2 blockade - advantages/uses: similar to haldol (high efficacy, few anti-ACh SEs) long acting decanoate - disadvantages/side effects: high incidence of EPS
26
Perphenazine - brand name - drug type / mech of action - advantages/uses - disadvantages/side effects
- brand name: trilafon - drug type / mech of action: 1st gen antipsychotic, D2 blockade - advantages/uses: moderate potency, lower risk of EPS - disadvantages/side effects: BID dosing
27
Chlorpromazine - brand name - drug type / mech of action - advantages/uses - disadvantages/side effects
- brand name: thorazine - drug type / mech of action: 1st gen antipsychotic, D2 blockade - advantages/uses: low potency so can use in pediatri population, fewer EPS side effects - disadvantages/side effects: lots of anti-ACh SEs --> dry mouth, tachy, urine retention, blurry vision, constipation, sedation (anti-H), weight gain, low potency
28
Risperidone - brand name - drug type / mech of action - advantages/uses - disadvantages/side effects
- brand name: risperdal - drug type / mech of action: 2nd gen antipsychotic, D2R blocker, 5HT2a receptor antagonist - advantages/uses: high potency, dissolving form, long acting consta form - disadvantages/side effects: hyperprolactinemia, high incidence of EPS
29
Olanzapine - brand name - drug type / mech of action - advantages/uses - disadvantages/side effects
- brand name: zyprexa - drug type / mech of action: 2nd gen antipsychotic, D2R blocker, 5HT2a receptor antagonist - advantages/uses: very effective, zydis form = dissolving tab - disadvantages/side effects: can cause significant metabolic risk --> central obesity, htn, DM, high TG/low HDL
30
Aripiprazole - brand name - drug type / mech of action - advantages/uses - disadvantages/side effects
- brand name: abilify - drug type / mech of action: 2nd gen antipsychotic, mixed agonist/antagonist - advantages/uses: adjunctive antidepressant, can be activating, weight neutral - disadvantages/side effects: can get akathesias
31
Quetiapine - brand name - drug type / mech of action - advantages/uses - disadvantages/side effects
- brand name: seroquel - drug type / mech of action: 2nd gen antipsychotic, D2R blocker, 5HT2a receptor antagonist - advantages/uses: useful as sleep aid, approved as monotherapy mood stabilizer, can be used in bipolar depression - disadvantages/side effects: sedation, qeight gain, dizziness, hard to tolerate
32
Ziprasidone - brand name - drug type / mech of action - advantages/uses - disadvantages/side effects
- brand name: geodon - drug type / mech of action: 2nd gen antipsychotic, D2R blocker, 5HT2a receptor antagonist - advantages/uses: weight neutral - disadvantages/side effects: QT prolongation, must be taken with food
33
Clozapine - brand name - drug type / mech of action - advantages/uses - disadvantages/side effects
- brand name: clozaril - drug type / mech of action: 2nd gen antipsychotic, D2 and D4 blockade, 5HT2A receptor antagonist - advantages/uses: extremely effective - disadvantages/side effects: significant sedation, weight gain, drooling, cardiomyopathy (in first 6 wks), agranulocytosis (need frequent blood monitoring), lowers seizure threshold
34
Lithium - brand name - drug type / mech of action - advantages/uses - common side effects - dangerous side effects - disadvantages
- brand name: eskalith - drug type / mech of action: mood stabilizer - advantages/uses: effective, not associated w/ weight gain - common side effects: polyuria, polydipsia, sedation, tremor - dangerous side effects: nephrogenic DI, renal impairment, thyroid dysfunction - disadvantages/side effects: lots of blood draws (Li level, BUN/Cr, T4/TSH), narrow therapeutic window --> can become toxic (N/V/D, COARSE TREMOR, MS change, renal failure, coma), contraindicated in renal disease, diuretic use, NSAID use
35
Valproic acid - brand name - drug type / mech of action - advantages/uses - common side effects - dangerous side effects - disadvantages/side effects
- brand name: depakote - drug type / mech of action: mood stabilizer - advantages/uses: slightly wider therapeutic window - common side effects: sedation, weight gain, alopecia - dangerous side effects: pancreatitis, hepatotoxicity, thrombocytopenia - disadvantages/side effects: blood draws to monitor levels, platelets, LFTs, p450 interactions, teratogen, potential for toxicity (N/V, ataxia, NYSTAGMUS, coma)
36
Carbamazepine / Oxcarbazepine - brand name - drug type / mech of action - advantages/uses - disadvantages/side effects
- brand name: tegretol / trileptal - drug type / mech of action: mood stabilizer / anti-epileptic - advantage/uses: mood stabilization - disadvantages/side effects: BM suppression, SIADH, autoinducer (induces own P450 metabolism --> can have decrease level at higher dose), many drug drug interactions (deactivates birth control, etc)
37
Lamotrigine - brand name - drug type / mech of action - advantages/uses - disadvantages/side effects
- brand name: lamictal - drug type / mech of action: mood stabilizer / anti-epileptic - advantages/uses: good for prevention bipolar depression (not acute episode) - disadvantages/side effects: titrate very slowly b/c risk Stevens-Johnson
38
Topiramate - brand name - drug type / mech of action - advantages/uses - disadvantages/side effects
- brand name: topamax - drug type / mech of action: mood stabilizer / anti-epileptic - advantages/uses: can promote weight loss, also treats headache, impulse control in borderline PD - disadvantages/side effects: no evidence of efficacy in mood stabilization, cognitive dulling (dopamax), kidney stones
39
Triazolam - brand name - drug type - use - onset of action/half-life
- brand name: halcion - drug type: benzo - use: use for difficulty falling asleep - onset of action/half-life: fast onset, short half-life = high addictive potential, higher withdrawal
40
Alprazolam - brand name - drug type - onset of action/half-life
- brand name: xanax - drug type: benzo - use: panic attacks - onset of action/half-life: fast/intermediate action, short/intermediate half life = highly addictive, higher risk withdrawal
41
Lorazepam - brand name - drug type - onset of action/half-life
- brand name: ativan - drug type: benzo - use: catatonia, acute agitation - onset of action/half-life: intermediate onset + half life
42
Clonazepam - brand name - drug type - onset of action/half-life
- brand name: klonipin - drug type: benzo - use: go-to benzo - onset of action/half-life: slow onset and intermediate/long half life = less potential for abuse
43
Diazepam - brand name - drug type - onset of action/half-life
- brand name: valium - drug type: benzo - onset of action/half-life: fast onset, long half-life
44
chlordiazepoxide - brand name - drug type - onset of action/half-life
- brand name: librium - drug type: benzo - use: EtOH withdrawal - onset of action/half-life: intermediate onset, long half-life
45
Zolpidem - brand name - drug type / mech of action - advantages/uses - disadvantages/side effects
- brand name: ambien - drug type / mech of action: hypnotic, difficulty sleeping - advantages/uses: widely available - disadvantages/side effects: can cause strange dreams, dissociative symptoms, less effective after 2 weeks
46
Zaleplon - brand name - drug type / mech of action - advantages/uses - disadvantages/side effects
- brand name: sonata - drug type / mech of action: hypnotic - advantages/uses: very short acting, may be taken if wake in middle of night - disadvantages/side effects: can be habit-forming
47
Ramelteon - brand name - drug type / mech of action - advantages/uses - disadvantages/side effects
- brand name: rozerem - drug type / mech of action: hypnotic - advantages/uses: similar to melatonin, unlikely to be habit-forming - disadvantages/side effects: expensive
48
Eszopiclone - brand name - drug type / mech of action - advantages/uses - disadvantages/side effects
- brand name: lunesta - drug type / mech of action: hypnotic - advantages/uses: can take for longer periods than other hypnotics - disadvantages/side effects: expensive, metal taste, withdrawal syndrome
49
Trazodone - brand name - drug type / mech of action - advantages/uses - disadvantages/side effects
- brand name: desyrel - drug type / mech of action: hypnotic - advantages/uses: benign, common on inpatient unit - disadvantages/side effects: morning grogginess, priapism
50
What are the HAM side effects?
H = antiHistamine: sedation, weight gain A = anitAdrenergic = hypotension M antiMuscarinic = dry mouth, blurred vision, urine retention
51
What are some types of drugs that have lots of HAM side effects?
TCAs and low potency first gen antipsychotics (chlorpromazine, thioridazine)
52
What are sx in 5HT syndrome?
confsuion, flushing, diaphoresis, tremor, myoclonic jerks, hyperthermia, hypertonicitiy, rhabdo, renal failure
53
What is drug of choice for EPS sx produced by neuroleptics?
benztropine
54
What is treatment for 5HT syndrome?
stop drugs = 1st line --> then maybe give cyproheptadine or ca channel blocker (nifedipine)
55
What foods to avoid in MAOI?
tyramine --> red wine, cheese, liver, cured meats
56
When do EPS sx occur?
with high potency traditional antipsychotics, wthin days of stating med
57
Which drugs cause hyperprolactinemia?
high potency traditional antipsychotics (haldol) and risperidone
58
When does tradvice dyskinesia occur?
years after antipsychotic use esp. high potency, can be irreversible
59
What are sx of NMS?
fever, tachycardia, hypertension, tremor, high CPK, lad pipe rigidity occurs most with high potency, 20% mortality rate
60
What is treatment for NMS?
stop the medication and supportive
61
What are some important CYP450 inducers?
- smoking - carbamazepine - barbiturates - st johns wor
62
What are some important CYP450 inhibitors?
- fluvoxamine - fluoxetine - paroxetine - duloxetine - sertraline
63
What is the difference in response rates among antidepressants? med vs placebo response?
all same response rates --> 70% respond to med, 30% of this is placebo response big difference is really in safety and side effects
64
How long should you try antidepressant?
1-2 months at full dose before consider medication change
65
What are unique feat of fluoxetine?
- longest half life --> no need to taper - safe in pregnancy - FDA approved in kids activating --> more common sleep changes and anxiety
66
What are some unique features of sertraline?
- highest risk of GI upset
67
What are some unique features of paroxetine?
- more anticholinergic --> sedating, constipation, weight gain, delirium / cognitive decline - short half life so significant discontinuation yndrome
68
What are some unique features of fluvoxamine?
- only currently approved for OCD and social anxiety, no MDD | - lots of p450 interactions
69
What are some unique features of citalopram?
- fewer sex side effects | - dose limited to 40mg in adults, 20mg in geri due to prolonging QT
70
What are some unique features of escitalopram?
fewest side effects, go to drug of choice
71
What is interaction SSRI and warfarin?
SSRI can increase level of warfarin so need to monitor when starting and stopping
72
What is clinical use of venlafaxine? major side effect?
MDD, GAD | similar SE to SSRI plus can cause increase BP
73
What is clinical use of duloxetine?
MDD with neuropathic pain or fibromyalgia
74
When is bupropion contraindicated?
epilepsy, eating disorder, currently on MAOI
75
What is clinical use of trazodone and nefazodone?
treat refractory major depression, MDD with anxiety, and insomnia
76
What are unique features of trazodone?
no sexual side effects, no affect on REM sleep SE: sedation and priapism
77
What are unique features of nefazodone?
no sexual side effects, no affect on REM sleep SE: sedation, black box warning of serious liver failure
78
What is clinical use of mirtazapine?
refractory major depression esp. in patients who need help with sleep and appetite/weight gain *no sex side effects
79
What is mech of action of TCAs?
inhibit reuptake of NE and 5HT
80
What are the two TCAs with less anticholinergic effects?
nortriptyline, desipramine
81
What is treatment for TCA overdose?
IV sodium bicarbonate
82
What are unqiue features of amitriptyline?
can use to treat chronic pain, migraines, insomnia
83
What are unique features of clomipramine?
can use to treat OCD | most 5HT specific
84
What are unique features of doxepin?
can treat chronic pain, sleep aid in low doess
85
What are unique features of imipramine?
use in enuresis and panic disorder
86
What are unique features of nortriptyline?
least likely to cause orthostasis --> use in elderly | can use to treat chronci pain
87
What are unique features of deipramine?
leas sedating and most activating of all TCAs
88
What is amoxapine?
tetracyclic antidepressants, can cause EPS
89
What are side ffects of TCAs?
highly protein bound and lipid soluble so interact with other meds that have high protein binding antiH --> sedation anti-A --> orthostasi, reflex tachycardia, arrhythmia, ekg change (wide QRS, QT, PR) anti-M --> dry mouth, cognition, etc
90
What drug is considered most effect in atypical depression?
MAOIs
91
What are effects of TCA overdose?
hypoventilation from CNS depression, delirium, myoclonus, hyperreflexia, seizure, coma
92
Which MAOI does not require following dietary restrictions?
selegiline
93
What is mech of action MAOIs?
pevent inactivation of biogenic amines like NE, 5HT, doapmine, tyramine by irrversibly inhibitiong MAO ``` MAO-A = 5HT MAO-B = NE both = dopamine, tyramine ```
94
When do you use MAOI?
certain types of refractory depression/panic/anxiety
95
How long do you have to weight when swithcing SSRI to MAOI?
2 wks, 5-6 wks if fluoxetine due to long half life
96
What is most common side effect of MAOI?
orhthostatic hypotension
97
What is mech of action typical vs atypical antipsychotics?
``` typical = block D2 atypical = block D2 and serotonin 2A ``` both effective at blocking + sx, atypical more effective at negative
98
What is unique about chlorpromazine?
low potency typical antipsychotic --> more anti-ACh effects (orthostasis), fewer EPS can cause bluish skin discoloration approved in pediatrics
99
What is unique about thioridazine?
low potency typical antipsychotic can cause retinitis pigmentosa
100
What is unique about thiothixeine?
midpotency typical antipsychoticic can cause ocular pigment cahnges
101
Which 3 antipsychotics have long acting IM forms?
haloperidol, fluphenazine, risperidone
102
What is unique about pimozide?
high potency typical antipsychotic associated w/ heart block VT, acrdiac effects
103
What are the 4 dopamine paths and their relation with neuroleptics?
mesolimbic = postivie sx of schizpohrneia treated by medication = nucleus accumbens, fornix, amygdala, hippocampus mesocortical = negative sx of schizophrenia nigrostrial = EPS sx of dopmine blockade tuberoinfundibular = increased prolactin SE of dopamine blockade
104
What are treatment options for EPS sx of neuroleptics?
- reduce dose of antipsychotic - benztropine (anticholinergic) - diphenhydramine (antihistamine) - amantadine (antiparkinson)
105
What is treatment of tardive dyskinesia?
discontinue current med and change med with less potential for tardvice
106
What are opthalmologic problems associated with antipsychotics?
irreversible retinal pigmentation with high dose thioridazine deposits in lens/cornea with chlorpromazine
107
Which type of antipsychotics most associated with lower seizure threshold?
low potency more than high potency
108
What are clinical uses of atypical antipsychotics?
acute mania, bipolar, adjunct to unipolar
109
What are unique features of clozapine?
- only antipsychotic shown to be more efficacious, good for treatment-resistant - high risk of agranulocytosis, seizures, metabolic, drooling - decreases risk of suicide
110
What are unique features of risperidone?
most likely to cause increased prolactin most EPS of atypicals long acting injetable
111
What are unique features of olanzapine?
most likely to cause weight gain besides clozapine
112
What are unique features of ziprasidone?
weight neutral
113
What are unique features of aripiprazole?
unique partial D2 agonism and D4 antagonism more activating (akathisia) less potential for weight gain
114
What is the only mood stabilizer that decreases suicidality?
lithium
115
What is drug of choice in acute mania and prophylaxis of manic/depressive?
lithium
116
Where is lithium metabolized?
kidney
117
How long before onset of action in lithium?
5-7 days
118
What are some factors that increase lithium levels?
- dehydration - salt deprivation - sweating (salt loss) - impaired renal function
119
What are some factors that decrease lithium levels?
- NSAIDs
120
What is specific use of carbamazepine?
useful in treating mixed episodes and rapid cycling bipolar, also trigeminal neuralgia
121
What tests should you order before starting carbamazepine?
CBC and LFTs --> can cause high LFTs leading to hepatitis and agranulocytosis/leukopenia
122
What are major side effects of lithium?
``` benign leukocytosis hypothyroid flat T wave on EKG GI disturbance weight gain nephrogenic DI fine tremor ```
123
What are specific uses of valproate?
mixed epsidoes bipolar and rapid cycling
124
What should you monitor in valproate?
LFTs and CBC --> can cause hepatitis
125
What is relationship valproate and lamotrigine levesl?
valproate increases lamotrigine | lamotrigine decreaes valproate
126
What is clinical use of lamotrtigien?
bipolar depression, modulate glutamate and aspartate via sodium channels
127
What is psych use of gabapentin?
adjunct for anxiety/sleep
128
What is psych use of pregabalin?
GAD and fibromyalgai
129
What are clinical uses of topiramate?
impulse vcontrol, anxiety
130
What is unique about topiramate?
can cause weight loss hypohchloremic non anion gap met acidosis and kidney stones cognitive slowing
131
When should you avoid clonazepam?
avoid w/ renal dysfunction
132
What is mech of action of zolpidema/zaleplon/escopiclone?
selective receptor binding tp benzo receptor 1 that is responsible for sedation use for short term treatment of insomnia
133
What is mech of action buspirone?
partial agonist at 5HT-1a not as effective as other options so often used in bombo with SRI for anxiety
134
What is mech of action hydroxyzine?
antihistamine used for quick acting short term anxiety
135
What are psych uses of propanolol?
autonomic effects of panic attacks or performance naxiety | akathisia
136
What should you watch out for in methylphenidate use?
wach for leukopenia, anemia, high LFTs | monitor BP and watch for weight loss, insmonia
137
What should you watch out for in atomoxetine?
rare liver toxicity, possible increase SI in kids/adolescents
138
What are some drugs that can cause psychosis?
sympathomimetics, analgesics, antibiotics (INH), anticholinergics, anticonvulsants, antihistamines, steroids, anti-PD
139
What are some drugs that can cause agitation/confusion/delirium?
antipsychotics, antidepressants, antiarrhythmics, steroids, glycosides, NSAIDS, antiasthmatics, antibiotics, anti PD, thyroid hormone
140
What are some drugs that can cause depression?
antihypertensives, antiPD, steroids, Ca cahnel blockers, NSAIDS, antibiotics, peptic ulcer drugs
141
What is psych effect of procainamide/quinidine?
confusion, delirium
142
What is psych effect of albuterol?
anxiety, confusion
143
What is psych effect of isoniazid?
psychosis
144
What is psych effect of tetracycline?
depression
145
What is psych effect of nifedipine, verapamil?
depression
146
What is psych effect of cimetidine?
depression, psychosis
147
What is psych effect of steroids?
aggressive/agitation, hypomania, anxiety, psychosis
148
what determines effectiveness of ECT?
length of postictal suppression not seizure duration
149
What are indications for ECT?
depression w/ psychotic feat, acute mania, catatonia, pts who fail other treatment or cannot tolerate
150
What is use of DBS?
chronic pain, PD, tremor, dystonia, MDD
151
What is use of repetitive transcranial magnetic stimulation?
weak electric current induced by rapidly changing mangentic field
152
What is use of light therapy?
sesonal affect d/o

Psych Clerkship (3 decks)

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