Pharm 49 Cram CSV

Question 1

DOC for influenza A

Answer 1

Amantadine

Question 2

DOC for RSV

Answer 2

Ribavirin

Question 3

DOC for CMV retinitis

Answer 3

Ganciclovir

Question 4

SE for ganciclovir

Answer 4

Neutro, leuko and thrombocytopenia

Question 5

Anti?viral agents associated with Stephen Johnson syndrome

Answer 5

Nevirapine, amprenavir

Question 6

HIV antiviral class known to have severe drug interactions by causing inhibition of metabolism

Answer 6

Protease inhibitors

Question 7

Antivirals that are teratogens

Answer 7

Delavirdine, efavirenz, and ribavirin

Question 8

Antivirals associated with neutropenia

Answer 8

Ganciclovir, zidovudine, saquinavir, and interferon

Question 9

HIV med used to reduce transmission during birth

Answer 9

AZT (zidovudine)

Question 10

MOA for Acyclovir

Answer 10

inhibits viral DNA sysnthesis 1. Competition with deoxyGTP for viral DNA polymerase 2. chain termination

Question 11

DOC for herpes simplex encephalitis and neonatal HSV infection

Answer 11

Intravenous acyclovir

Question 12

Greater t1/2 than acyclovir

Answer 12

Valcyclovir

Question 13

MOA for Docosanol (Abreva)

Answer 13

Inhibits fusion between plasma membrane and HSV envelope

Question 14

What is required to activate Ganciclovir

Answer 14

protein kinase phosphotransferase UL97

Question 15

What drug would you use to treat CMV

Answer 15

Ganciclovir

Question 16

What is the differences in SE Ganciclovir vs Acyclovir

Answer 16

Ganciclovir has dose limiting hematoxicity

Question 17

What drugs increase the levels of Ganciclovir

Answer 17

Probenecid & trimethoprim

Question 18

What dual therapy is effective in delaying CMV retinitis

Answer 18

Ganciclovir & Fosarnet

Question 19

MOA of Foscarnet

Answer 19

inhibits herpesvirus DNA & RNA polymerase & HIV reverse transcriptase

Question 20

What drugs should be avoided when treating with Foscarnet due to nephrotoxicity

Answer 20

amphotericin B, pentamidine, aminoglycosides, Cidofovir

Question 21

SE of Foscarnet

Answer 21

Hypocalcemia

Question 22

Pt is on Pentamidine IV for PCP what drug should be avoided?

Answer 22

Foscarnet

Question 23

Drug used against resistant strains of CMV or HSV

Answer 23

Cidofovir (does not depend on thymidine kinase)

Question 24

IV cidofovir must be given with?

Answer 24

Probenecid to block active tubular secretion to decrease nephrotoxicity

Question 25

What drugs are not useful against HIV?2

Answer 25

NNRTI's

Question 26

Characteristics of NRTI's

Answer 26

1. prodrugs 2. Nonspecific kinase 3. Bone Marrow supression

Question 27

NRTI's associated with dyslipidemia and insulin resistance

Answer 27

Zidovudine and Stavudine

Question 28

NRTI with significant allergy SE

Answer 28

Abacavir (ABC)

Question 29

NRTI with risk of peripheral distal sensory neuropathy

Answer 29

Didanosine (DDI), Zalcitabine

Question 30

CI for taking Emtricitabine (FTC)

Answer 30

Children, Prego, renal or hepatic failure, metronidazole, disulfiram

Question 31

Drug used prophylaxis in reducing HIV acquisition

Answer 31

Emtricitabine (FTC), Tenofovir

Question 32

Common mutation in Emtricitabine and Lamivudine

Answer 32

M184V/I

Question 33

Discontiuation of Lamivudine (ETC) is associated with hepatitis, why?

Answer 33

Lamivudine treats both HIV & HBV

Question 34

Lmivudine works synergistically with

Answer 34

Zidovudine(AZT) and Stavudine

Question 35

Drug favored over AZT due to decreased myelosuppression

Answer 35

Stavudine (d4T)

Question 36

Which drug should be avoid with lactose intolerance

Answer 36

Tenofovir

Question 37

SE of Tenofovir

Answer 37

bone toxicity (osteomalacia)

Question 38

What drug inhibits Zalcitabine in vitro?

Answer 38

Lamivudine

Question 39

MOA of Zidovudine (AZT)(ZDV)

Answer 39

blocks DNA polymerase

Question 40

Which drug is the most hepatotoxic of the NRTIs

Answer 40

Zidovudine (AZT) (ZDV)

Question 41

Characteristics of NNRTI's

Answer 41

1. Not Pro drug 2. No bone marrow suppression 3. metabolism through CYP

Question 42

Which NNRTI prolongs the elimination of indinavir and saquinavir allowing PID

Answer 42

Delavirdine

Question 43

SE of Efavirenz (NNRTI)

Answer 43

Nightmares

Question 44

NNRTI that prevents vertical transmission

Answer 44

Nevirapine

Question 45

Common things among Protease inhibitors

Answer 45

1. Aspartate protease 2. insulin resis 3. QT prolongation

Question 46

PI that has least amount of dyslipidemia

Answer 46

Atazanavir

Question 47

Pi that must be co?administered with ritonavir

Answer 47

Darunavir

Question 48

PI that is CI in pts with sulfa allergy

Answer 48

Fosamprenavir & Tipranavir

Question 49

PI with most common SE dyslipedemia

Answer 49

Indinavir

Question 50

Which PI is contraindicated with rifampin

Answer 50

lopinarvir/ritonavir

Question 51

Which PI can be admisitered to PREGO

Answer 51

Nelfinavir

Question 52

Which PI is most CI in someone with QT prolongation

Answer 52

Ritonvair

Question 53

MOA for Enfuvirtide

Answer 53

binds to gp 41 subunit of viral envelope glycoprotein, prevents conf. change

Question 54

SE of enfuvirtide

Answer 54

painful erythematous nodules

Question 55

MOA for Maraviroc

Answer 55

binds to CCR5

Question 56

Resistance to Maraviroc is associated with

Answer 56

V3 loop of gp 120

Question 57

SE Maraviroc

Answer 57

CYP3A, postural hypotension, hepatox, increased cardiovascular risk

Question 58

MOA of Raltegravir

Answer 58

binds integrase (inhibits strand transfer and final step)

Question 59

MOA of Ribavirin

Answer 59

inhibits viral RNA dependent Polymerase

Question 60

Drugs that affect uncoating

Answer 60

Amantadine & Rimantadine

Question 61

SE of Amantadine

Answer 61

Atropine like, livedo reticularis

Question 62

Areosol given to infants with RSV

Answer 62

Ribavirin