Pharm 6 Anti-virals

Question 1

DNA virus RNA (protein transcription) blocker

Answer 1

Foscarnet

Question 2

DNA virus DNA blocker (4)

Answer 2

Foscarnet
Trifluridine
Acyclovir
Gancyclovir

Question 3

4 DNA viruses

Answer 3

Adenoviruses (pharyngoconjunctivitis)
Papillomaviruses
HSV
VZV

Question 4

Acyclovir

Answer 4

Prodrug (Ac-TP)

• SE Nausea, diarrhea
• SE Transient renal dysfunction (hydrate)

Question 5

Gancyclovir toxicity

Answer 5

Neutropenia

-CNS effects, carcinogenic

Question 6

Foscarnet

Answer 6

Block DNA/RNA replication

• Tx gancyclovir-resistant CMV
• SE Nephrotoxicity

Question 7

Trifluridine

Answer 7

Block DNA replication

• Tx HSV keratoconjunctivitis
• SE Corneal inflammation

Question 8

HSV mnemonic

Answer 8

For herpes give Acyclovir To patient

• Foscarnet
• Acyclovir
• Trifluridine

Question 9

CMV mnemonic

Answer 9

For CMV give Gancyclovir

• Foscarnet
• Gancyclovir

Question 10

Flu Tx

Answer 10

Neuraminidase inhibitors (prevention)

• Zanamivir
• Oseltamivir

Question 11

Zanamivir SE

Answer 11

Bronchospasm in asthmatics

Question 12

Oseltamivir SE

Answer 12

Nausea

Question 13

Interferons

Answer 13

Immune response against virus

-Induce JAK-STAT in patients, cease protein transcription

Question 14

Interferon indication

Answer 14

Kaposi sarcoma
Hep C (w/Ribavirin)

Question 15

Ribavirin mnemonic

Answer 15

RIBAvirin

• RSV
• Influenza B
• Adenoviruses

Question 16

Ribavirin SE

Answer 16

Anemia (systemic, not aerosol)

Teratogenic

Question 17

HIV Tx indication

Answer 17

Not at CD4 above 400

Question 18

HAART therapy SE (4)

Answer 18

Metabolic syndrome (DM)
Lipodystrophy (hunchback)
Liver problems
Increased bleeding

Question 19

AZT

Answer 19

Thymidine-like reverse-transcriptase inhibitor

-Given for pregnant women

Question 20

AZT toxicity inducing drugs

Answer 20

PAL, I Care

• Probenecid (gout)
• Acetaminophen
• Lorazepam
• Indomethacin (NSAID)
• Cimetidine (anti-H)

Question 21

AZT toxicity

Answer 21

-Bone marrow (anemia, leukopenia)

Question 22

Didanosine

Answer 22

AZT resistance

-SE severe (pancreas, liver)

Question 23

Zalcitabine

Answer 23

AZT adjunct

-SE peripheral neuropathy

Question 24

Stavudine SE

Answer 24

• peripheral neuropathy

- lactic acidosis, hyperlipidemia (w/AZT)

Question 25

Lamuvidine | Emtricitabine

Answer 25

Slows AZT resistance | -SE pancreatitis in children

Question 26

Trizivir

Answer 26

Lamuvidine, Zidovudine (AZT), Abacavir

Question 27

Abacavir

Answer 27

Adjunct to AZT or Lamuvidine | -SE hypersensitivity reaction

Question 28

Tenofovir

Answer 28

Chain terminator, NRTI - Tx HIV, HBV - Prophylactic??

Question 29

Tenofovir SE

Answer 29

- Flatulence | - CI with lamuvidine, abacavir, didanosine

Question 30

Nucleoside RT inhibitor mnemonic

Answer 30

ZIDdy went NUClear and DID STAB A BABy LAMb - Zidovudine - Didanosine - Stavudine - Abacavir - Lamivudine

Question 31

NNRTI mechanism

Answer 31

Modify reverse transcriptase conformation

Question 32

Efavirenz

Answer 32

NNRTI - Use with lamuvidine, AZT - SE CYP2B6 (psych) interactions

Question 33

Nevirapine

Answer 33

NNRTI - SE Rash - CI St. John's wort - lowers estrogen OC effectiveness

Question 34

Delavirdine

Answer 34

NNRTI | -CYP3A4 interactions (psych, rifampin)

Question 35

Protease inhibitor -suffix

Answer 35

-navir

Question 36

Good protease inhibitor Tx for resistant HIV

Answer 36

Amprenavir | -Lopinavir/Ritonavir

Question 37

Enfuvirtide

Answer 37

``` Fusion inhibitor (hemagglutinin) -Inject twice daily ```

Question 38

Maraviroc

Answer 38

``` Fusion inhibitor (CCR5 chemokine-R) -Many toxicities ```

Question 39

DNA virus Tx -suffix

Answer 39

-lovir-

Question 40

RNA virus Tx -suffix

Answer 40

- ine - mivir - avir