Pharm

Question 1

What is the precursor for Dopamine?

Answer 1

Tyrosine

Question 2

What is increased in mania, psychosis, and schizophrenia?

Answer 2

Dopamine

Question 3

What is decreased in parkinson’s disease?

Answer 3

Dopamine

Question 4

What is the major inhibitory NT in the CNS?

Answer 4

GABA

Question 5

Alchohol, benzodiazepines, and barbituaates are agonists of what receptor?

Answer 5

GABA

Question 6

Decreased levels of GABA are associated with what disorders?

Answer 6

Anxiety and Epilepsy

Question 7

What is the major excitary NT in the CNS?

Answer 7

Glutamate

Question 8

What is increased in epilepsy, schizophrenia, and Alzheimers?

Answer 8

Glutamate

Question 9

What inhibitory NT controls gultamate activity in the brain and spinal cord?

Answer 9

Glycine

Question 10

What NT is responsible for sleep modulation and sateiy?

Answer 10

Histamine

Question 11

What classes of drugs block H1 and lead to sedation and increased appetite?

Answer 11

Antipsychotics and Tricyclic antidepressants

Question 12

What NT is increased in anxiety?

Answer 12

NE

Question 13

What NT is decreased in depression?

Answer 13

NE

Question 14

What NT regulates mood, temp, sexualilty, and sleep?

Answer 14

Serotonin

Question 15

What is the precursor of serotonin?

Answer 15

Tyrptophan

Question 16

What degrades serototnin?

Answer 16

Monoamine Oxidase

Question 17

What NT is decreased in depression, bipolar, and anxiety, but increased in schizophrenia?

Answer 17

Serotnoinin

Question 18

Where are histaminergic nuerons located?

Answer 18

central posterior hypothalmus

Question 19

Where is thr primary site for NE synthesis?

Answer 19

locus ceruleus

Question 20

What stucture releases serotonin to projections throughout the brain stem?

Answer 20

Raphe Nucelus

Question 21

Substantia nigra pars compacta and tegmenatal area are important sites of what type of neurons in the brain?

Answer 21

dopaminergi nuerons

Question 22

Morphine is what type of drug class?

Answer 22

Opiod

Question 23

What opiod can be used as a iv anesthetic?

Answer 23

Fentanyl

Question 24

3 methyl morphine is what opiod?

Answer 24

Codeine

Question 25

Hydromorphone is more potent than which drug and should never be chewed?

Answer 25

Morphine

Question 26

What opiod is used as a treatment for herione addiction?

Answer 26

Methadone

Question 27

Which opidod is less potent than morphine and can cause CNS depression?

Answer 27

Meperidine

Question 28

Oxycodone is used for what type of pain?

Answer 28

Weak

Question 29

Loperamide is used to treat which symptom?

Answer 29

Diarehhia

Question 30

What drugs are used to treat an OD of opiates?

Answer 30

Naloxene and Naltrexone

Question 31

Which opiods are used as an antitussive?

Answer 31

Dextromethorphan and COedine

Question 32

What is a major endogenous opiod?

Answer 32

Enkephalin

Question 33

What is located in the PAG, Raphe Magnus and doesal horn?

Answer 33

Enkephalin

Question 34

What is the site of action for NSAIDs and other OTC analgesics?

Answer 34

Sensory nerve endings

Question 35

What is the site of action for local anethetics>

Answer 35

Nerve trunks and spinal cord where they prevent nerve conduction

Question 36

What analgesic works at the spinal cord, thalamus, PAG, Raphe Nucleus and cortex of the brain?

Answer 36

OPiates

Question 37

Where do general anthestics work in the NS?

Answer 37

cortex

Question 38

What analgesic hyper polarize and inhibit NT release everywhere except the PAG and Raphe Mangnus?

Answer 38

OPiates

Question 39

What is the mechanism of pain control in the PAG and Raphe Magnus by opaites?

Answer 39

OPiates activate descending [ain control pathways

Question 40

What opidio partial agonist when given with morphine antagonixze its effects?

Answer 40

Buprenorphine

Question 41

How do opiods inhibit NT release and decrease pain?

Answer 41

Increase K+ conductance (outflow), Decrease Ca+ inflow (Inhibit andenyl cyclase)

Question 42

Drowisness, Nausea, Vomiting and Respiratory Depression are side effects of what drugs?

Answer 42

OPiates

Question 43

Which anaglesic do you use after an MI?

Answer 43

Morphine

Question 44

Does Morphine Increase or Decrease Prolactin?

Answer 44

Increase

Question 45

Does Morphine increase or Decrease Growth Hormone?

Answer 45

INcrease

Question 46

Does Morphine Increase or Decrease TSH?

Answer 46

reduce

Question 47

Does Morphine Increase or Decrease ACTH

Answer 47

reduce

Question 48

Does Morphine Increase or Decrease LH?

Answer 48

reduce

Question 49

Which Local ANthestics are Amides?

Answer 49

Lidocaine and Bupivacine

Question 50

What local analgesic causes vascontriction because of inhibition of NE uptake?

Answer 50

Cocaine

Question 51

SHorter nerves are blocked before....

Answer 51

Longer nerves

Question 52

Which fire faster: pain or motor?

Answer 52

Pain

Question 53

Which pain fibers are the most susceptible to block in order from most to least?

Answer 53

C>delta>gamma>beta>alpha

Question 54

What is usually coadminsitred with local anthestics to decrease sysstemic distrubution and toxicity?

Answer 54

Epinephrine or vasoconstrictors

Question 55

Local ansthetics side effects include:

Answer 55

CNS: seizures-->depression--->death | Cardio depression

Question 56

Which 3 local anthestics are suitable for injection?

Answer 56

Procaine, Lidocaine, Bupivacaine

Question 57

Which 3 local anthestis are suitable for mucous membranes and skin?

Answer 57

Benzocaine, Lidocaine, Cocaine

Question 58

What is the only anthestics used for eyes?

Answer 58

Proparacaine

Question 59

What are the drugs of choice for Anxiety?

Answer 59

SSRI SNRI buspirone

Question 60

What drugs do you use for bipolar disorder?

Answer 60

``` Lithium Aytpical antipsychotics Valporic Acid Carbamazepine (LAVAC) ```

Question 61

Drugs of choice for Depression?

Answer 61

``` SSRI SNRI TCAs buspirone mirtazapine ```

Question 62

Drugs for panic disorder?

Answer 62

SSRI venlafaxine benzodiazepines

Question 63

PTSD drugs?

Answer 63

SSRI

Question 64

What are the drugs for SSRIs?

Answer 64

``` FLuoxetine PARoxetine SErtraline CITalopram FLashbacks PARalyze SEnior CITizens ```

Question 65

Which Anti-depressants cause serontinin syndrome?

Answer 65

MAOI SSRI SNRI TCAs

Question 66

Name the SNRI drugs (2)

Answer 66

Venlafaxine | Duloxetine

Question 67

TCA-depressant drugs (4)

Answer 67

``` Desipramine Amitriptyline Notriptyline Imipramine DANI needs TRIple ```

Question 68

What is the major antidepressant that causes sexual dysfunction?

Answer 68

SSRI

Question 69

SNRI's cause...

Answer 69

increase in BP

Question 70

What are the Tri-C's of TCA side effects?

Answer 70

Convulsions Coma Cardiotoxicity

Question 71

What type of drug is Tranylcypromine?

Answer 71

MAOI

Question 72

What are MAOI used for?

Answer 72

Atypical depression

Question 73

What are the three atypical antidepressants?

Answer 73

Bupropion Mirtazapine Trazodone

Question 74

What anti-depressant has no sexual sideeefect?

Answer 74

Bupropion

Question 75

What drug group is a agonist for serotonin 5HT1?

Answer 75

Triptans and Ergot alkaloids

Question 76

What are three drugs that are used for prophylactic for migraines?

Answer 76

Propanolol Topiramate Amitryptyline

Question 77

What are triptans contraindicated for?

Answer 77

Hypertension, Heart Disease, Cerebrovascular

Question 78

Will a shorter or longer nerve be blocked first?

Answer 78

Shorter

Question 79

Will a nerve firing more often than be blocked before a nerve that fires less?

Answer 79

More

Question 80

The fibers on the outside are blocked before the fibers on the inside. T/F?

Answer 80

True

Question 81

Sensory nerve fibers are blocked...

Answer 81

before motor fibers

Question 82

Which non-benzos increase sleep duration?

Answer 82

Zolpidem and Eszopicolone

Question 83

Which non benzo decreasae the latency to sleep?

Answer 83

Zaleplon

Question 84

What sleep drug is an agnoist for MT1/MT2?

Answer 84

Rameleton

Question 85

baclofen targets is an agonist for which receptor?

Answer 85

GABA-B

Question 86

Tizanidine is a agonsit for which receptor?

Answer 86

Alpha 2