Pharm

Question 1

what is the combination treatment for ALL (combination tx is used b/c of resistance)

Answer 1

vincristine + prednisone + ________ (6-MP, cyclophosphamide, or daunorubicin)

Question 2

most active agent for AML

Answer 2

cytarabine

Question 3

best combo tx for AML

Answer 3

cytarabine + idarubicin

Question 4

combo tx for AML is followed by ______

Answer 4

high-dose chemo and total body irradiation followed by immunosuprression

Question 5

3 first line treatments for chronic phase CML

Answer 5

imatibin, dasatibin, nilotinib

Question 6

besides the first line tx for CML imatibin, dasatibin, nilotinib, what other drug can be used

Answer 6

busulfan

Question 7

two regimens for CLL

Answer 7

COP: cyclophosphamide + vincristine + prednisone

CHOP: cyclophosphamide + vincristine + prednisone + doxorubicin

Question 8

besides COP and CHOP, what agents can be used for CLL

Answer 8

bendamustine (monotherapy or w/ prednisone)

fludarabine (monotherapy or w/ cyclophosphamide and mitoxantrone)

Question 9

regimen for hodgkin’s lymphoma stage I and IIa

Answer 9

ABVD - doxorubicin, bleomycin, vinblastine, dacarbazine

Question 10

regimen for hodgkin’s lymphoma stage III and IV

Answer 10

MOPP: mechlorethamine, vincristine, procarbazine, prednisone

ABVD: doxorubicin, bleomycin, vinblastine, dacarbazine

Stanford V: doxorubicin, vinblastine, mechlorethamine, vincristine, bleomycin, etoposide, prednisone

Question 11

compare MOPP, ABVD, and stanford V regimens for hodgkin’s lymphoma III and IV

Answer 11

ABVD: more effective and less toxic than MOPP

stanford V: middle best

MOPP: most adverse effects

Question 12

regimen for diffuse non-hodgkin’s lymphoma

Answer 12

CHOP: cyclophosphamide, doxorubicin, vincristine, prednisone

Question 13

regimen for nodular (follicular) non-hodgkin’s lymphoma

Answer 13

bendamustine

Question 14

regimen for multiple myeloma

Answer 14

melphalan + prednisone

Question 15

treatment for stage 1 breast cancer

Answer 15

surgery alone

Question 16

treatment for stage 2 breast cancer

Answer 16

post-operative:

CMF: cyclophosphamide, methotrexate, 5-FU

FAC: 5-FU, doxorubicin, cyclophosphamide

Question 17

treatment for hormone refractory prostate CA

Answer 17

docetaxel + prednisone

Question 18

regimens for high risk stage II and III colorectal CA

Answer 18

FOLFOX: leucovorin + 5-FU + oxaliplatin

XELOX: capecitabine + oxaliplatin

Question 19

regimens for metastatic colorectal cancer

Answer 19

FOLFIRI: leucovorin + 5-FU + irinotecan

FOLFIRI or FOLFOX + bevacizumab or cetuximab/panitumumab

Question 20

what agent do you use for chemo-refractory setting of colorectal cancer

Answer 20

TAS-102

Question 21

standard treatment for non-small cell lung CA with non-squamous histology

Answer 21

bevacizumab + carboplatin + paclitaxel

Question 22

treatment for non-small cell lung CA with squamous cell histology

Answer 22

cisplatin or carboplatin + cetuximab

Question 23

agent used for maintenance chemotherapy in non-small cell lung CA

Answer 23

pemetrexed

Question 24

targeted therapy for non-small cell lung CA pts with sensitizing EGFR mutations

first line tx for metastatic NSCLC w/ EGFR mutations

tx for metastatic NSCLC w/ EGFR T790 mutations

Answer 24

erlotinib

afatinib

osimertinib

Question 25

what agent is used in NSCLC that has progressed or after standard platinum-based chemo

Answer 25

nivolumab

Question 26

regimen for small cell lung cancer

Answer 26

cisplatin + etoposide or cisplatin + irinotecan

Question 27

what is used as second line monotherapy in small cell lung CA pts that failed platinum based regimen

Answer 27

topotecan

Question 28

tx for stage 1 ovarian CA

Answer 28

cisplatin and cyclophosphamide

Question 29

tx for stage III and IV ovarian CA

Answer 29

carboplatin and paclitaxel

Question 30

tx for recurrent dz of ovarian CA

Answer 30

topotecan or liposomal doxorubicin

Question 31

tx testicular CA

Answer 31

PEB: cisplatin + etoposide + bleomycin

Question 32

tx metastatic malignant melanoma

Answer 32

dacarbazine and cisplatin

Question 33

tx for unresectable or metastatic melanoma as monotherapy

Answer 33

nivolumab or pembrolizumab

Question 34

monotherapy and regmin tx brain cancer

Answer 34

monotherapy: carmustine regimen: PCV: procarbazine + vincristine

Question 35

tx for adult glioblastoma multiforme

Answer 35

bevacizumab