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ENDOREPRO II Exam I > [PHARM] Antenatal and Perinatal Pharmacology [Wolff] > Flashcards

[PHARM] Antenatal and Perinatal Pharmacology [Wolff] Flashcards

(48 cards)

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1
Q

What is the drug used for?

Misoprostol

A

Induction of labor

&

Control post-partum bleeding

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2
Q

What is the drug used for?

Dinoprostone

A

Induction of labor

&

Post-partum bleeding

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3
Q

What is the drug used for?

Carboprost

A

Induction of labor

&

Control of post-partum bleeding

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4
Q

What is the drug used for?

Oxytocin

A

Induction of labor

&

Control post-partum bleeding

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5
Q

What is the drug used for?

Ergot alkaloids

A

Induction of labor

&

Control post-partum bleeding

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6
Q

What is the drug used for?

Terbutaline

A

Delay labor

(tocolytics)

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7
Q

What is the drug used for?

Nifedipine

A

Delay labor

(tocolytics)

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8
Q

What is the drug used for?

MgSO4

A

Delay labor

(tocolytics)

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9
Q

What is the drug used for?

Atosiban

A

Delay labor

(tocolytics)

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10
Q

What is the drug used for?

Alprostadil

A

Maintain patent ductus arteriosus

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11
Q

What is the drug used for?

Indomethacin

A

Delay labor (tocolytic)

AND

CLOSE patent ductus arteriosus

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12
Q

What is the drug used for?

Ibuprofen

A

CLOSE patent ductus arteriosus

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13
Q

What is the drug used for?

Alpha-methyldopa

A

Anti-hypertensive in pregnancy

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14
Q

What is the drug used for?

Labetalol

A

Anti-hypertensive in pregnancy

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15
Q

What is the drug used for?

Hydralazine

A

Anti-hypertensive in pregnancy

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16
Q

What is the drug used for?

Sodium nitroprusside

A

Anti hypertensive in pregnancy

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17
Q

What are the (3) corticosteroids?

A

Cortisol

Bethamethasone

Dexamethasone

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18
Q

What are key prostaglandins involved in uterine myocyte RELAXATION?

A

CRH

B2 sympathomimetics

Prostaglandin E2

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19
Q

What are key prostaglandins involved in uterine myocyte CONTRACTION?

A

Oxytocin

Thrombin

Prostaglandin F2alpha

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20
Q

Describe what is occuring during cervical ripening

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A

Initially, the cervix contains a densely packed collagen fiber plug that prevents the fetus from leaving the uterus

During cervical ripening, the plug becomes loosely associated

21
Q

What are the drugs that are used to stimulate the uterus called?

22
Q

MOA of misoprostol?

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A

Prostaglandin E1 analog

23
Q

Clinical indications for misoprostol?

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A
  • Termination of intrauterine pregnancy
  • OFF LABEL = cervical ripening
24
Q

Contraindications of misoprostol

Study These Flashcards
A

Pregnancy (unless aborting)

Previous cesarean delivery (disrupts uterine scar leading to rupture)

25
AE of **misoprostol?**
MATERNAL = N/V, chills, shivering, Tachysystole FETAL= **hypoxia** due to prolonged uterine contractions
26
MOA of **dinoprostone?**
Prostaglandin E2 analog
27
Clinical indications for **dinoprostone?**
Cervical ripening Induction of labor
28
Contraindications for **dinoprostone?**
Pregnancy (unless aborting) Previous cesarean delivery (disrupts previous uterine scar)
29
Maternal AE for **dinoprostone?**
N/V, fever, chills During abortion, **fever unresponsive to NSAIDS**
30
Fetal AE of **dinoprostone?**
Hypoxia
31
MOA of **carboprost?**
Prostaglandin F2alpha analog
32
Indications for **carboprost?**
3rd line treatment for Inducing **abortion** and Post-partum hemostasis for **refractory bleeding**
33
Important to note about Maternal AE of **carboprost?**
TONS of AE, pt will feel awful after taking Hypertension, pulmonary edema, chills/shivering, dizziness, gagging, heartburn, etc...
34
MOA of **oxytocin?**
Posterior pituitary hormone
35
Clinical indications of **oxytocin?**
Induction of labor
36
AE of **oxytocin?**
Water intoxication (rare)
37
Contraindications for **oxytocin?**
DO NOT INDUCE LABOR IF... Lungs are not mature or Cervix is NOT RIPE
38
What is the historic drug used to induce labor?
Ergot alkaloids
39
What is the issue with using **ergot alkaloids?**
Causes **prolonged tonic uterine contraction** CONSTRICTS aterioles and veins
40
What are two conditions that would warrent pre-term delivery?
**HELLP** (hemolysis, elevated liver enzymes, low platelet count) **Pre-eclampsia**
41
What is the function of **fetal cortisol?**
Drives lung maturation
42
What are the two options to give to drive fetal lung maturation?
Bethamethasone Dexamethasone
43
What is **magnesium sulfate** used for?
Prevents **eclamptic seizures**
44
MOA of **terbutaline?**
Beta2 agonist
45
MOA of **nifedipine?**
Calcium channel blocker
46
What are the BEST choices to use as a **tocolytic** in the USA?
Nifedipine Indomethacin
47
MOA of alprostadil?
Synthetic PGE1
48

ENDOREPRO II Exam I (26 decks)

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