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SMB 3 > Pharm-Antirheumatic > Flashcards

Pharm-Antirheumatic Flashcards

(21 cards)

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1
Q

Methotrexate- Indications

A

Ra & psoriatic arthritis

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2
Q

Methotrexate- MOA

A

folate agonist- inhibits lymphocyte proliferation

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3
Q

Methotrexate- AE

A

stomach ulcers, nausea, cirrhosis of liver

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4
Q

Hydroxychloroquine- Indications

A

Mild RA, combined with methotrexate

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5
Q

Hydroxychloroquine- MOA

A

inhibits phospholipase A2, and platelet aggregation

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6
Q

Hydroxychloroquine- AE

A

ocular toxicity, retinal damage, CNS disturbances, GI upset, skin discoloration

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7
Q

Sulfasalazine- Indications

A

Early, mild RA in combination with hydroxychloroquine & methotrexate

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8
Q

Sulfasalazine- MOA

A

Unknown, COX & prostaglandin inhibition

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9
Q

Sulfasalazine- AE

A

Leukopenia, anorexia, HA/N/V, hypersensitivity

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10
Q

Azathioprine- Indications

A

RA, lupus, psoriatic arthritis

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11
Q

Azathioprine- MOA

A

T-lymphocyte inhibition

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12
Q

Azathioprine- AE

A

mutagenic in pregnancy, leukopenia, thrombocytopnea, anemia

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13
Q

Penicillamine- Indications

A

Slows progression of bone destruction and RA- in conjunction with NSAIDs/ glucocorticoids

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14
Q

Penicillamine- MOA

A

Unknown, prevents cycstine calculi, removes excess heavy metals

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15
Q

Penicillamine- AE

A

Severe! dermatologic nephritis, aplastic anemia,

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16
Q

Ethanercept- Indications

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A

Moderate to sever RA, psoriatic arthritis, ankylosing sponylitis

17
Q

Ethanercept- MOA

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A

TNF inhibitor

18
Q

Ethanercept- AE

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A

Infection at injection site, sepsis

19
Q

Infliximab- Indications

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A

In conjunction with methotrexate- RA, psoriatic arthritis, ankylosing spondylitis

20
Q

Infliximab- MOA

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A

Antibody- TNF alpha inhibitor

21
Q

Infliximab- AE

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A

Infusion site reaction, chills, pruritis, urticaria, opportunistic infections

SMB 3 (11 decks)

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