Pharm: Cardio

Question 1

Alpha Blocks MOA

Answer 1

antagonizes peripheral alpha-1 adrenergic receptors

Question 2

What are the first line meds uses for AA w/HTN?

Answer 2

• Diuretics (Thiazide - HCTZ)
• Calcium Channel Blocker

Question 3

Alpha Blockers: Cautions

Answer 3

• NO pregnancy & hypotension if used w/ Sildenofil (Viagra)

Question 4

List Alpha Blocker Meds

Answer 4

• Prazosin
• Terazosin
• Doxazosin
• Tamsulosin

Question 5

Alpha Blockers work mostly in:

Answer 5

• vascular SM
• bladder neck
• prostate gland

Question 6

If a patients has a sulfa allergy, what should you avoid & what should you use?

Answer 6

• avoid HCTZ
• uses CCB

Question 7

Prazosin: Uses

Answer 7

-HTN
- BPH
- Nightmares, PTSD

Question 8

Terazosin: Uses

Answer 8

• HTN
• BHP

Question 9

Doxazosin: Uses

Answer 9

• HTN
• BPH

Question 10

Tamsulosin: Uses

Answer 10

• BPH
• nephrolithiasis

Question 11

When do you take Prazosin?

Answer 11

1st dose at bedtime

Question 12

When do you take Terazosin?

Answer 12

@ bedtime

Question 13

When do you take Doxazosin?

Answer 13

@ bedtime

Question 14

When do you take Tamsulosin?

Answer 14

30 mins after eating in the morning

Question 15

Tamsulosin: Common Rxns

Answer 15

• abnormal ejaculation
• dizziness
• Rhinitis
• Cough

Question 16

Beta Blockers are located where & causes what?

Answer 16

• cardiac nodal tissue (Incr CO)
• conducting system (decr HR)
• contracting myocytes (reduce contractility)

Question 17

BB: Relative Contraindications

Answer 17

• Asthma & COPD (especially non-selective Beta Blockers–>Carbetalol)
• Cocaine Use
• Diabetes Mellitus

Question 18

BB: Absolute Contraindications

Answer 18

Bradycardia or heart block

Question 19

List the 1st gen non-selective BB

Answer 19

• Propranolol
• Timolol

Question 20

List the 2nd gen selective B1B

Answer 20

• Atenolol
• Metoprolol

Question 21

List the 3rd gen non-selective B & A1 Blocker)

Answer 21

Non-selective
- carvedilol
- Labetalol

Question 22

List BB meds

Answer 22

• Atenolol
• Metoprolol
• Propranolol
• Carvedilol
• Labetalol

Question 23

BB: Cautions

Answer 23

• avoid abrupt discontinuation can cause rebound tachycardia
• DON’T USE in 2nd/3rd degree AV block, decomp HF, sinus brady

Question 24

List the selective antagonist for B1 adrenergic receptor meds

Answer 24

• Atenolol
• Metoprolol

Question 25

Atenolol: Uses

Answer 25

- HTN - Angina - CV event, prevention, post MI (2ndary) - migraine HA, prophy

Question 26

Metoprolol: Uses

Answer 26

- HTN - Angina - CHF - *migraine HA prophy Consider giving a BB if a NEW diastolic murmur to decr pulsatile flow in case of a potential aortic dissection “tearing chest (or back) pain”

Question 27

List the non-selective antagonist for B1& B2 adrenergic receptor meds

Answer 27

- Propranolol - Carvedilol

Question 28

Propranolol: Uses

Answer 28

- HTN - Angina - CV prevention, post-MI - AFib/flutter - supraventricular arrhythmias - migraine HA prophy - essential tremor - idiopathic hypertrophic subaortic stenosis (IHSS) - pheochromocytoma, adjunct tx

Question 50

Initial Tx: black pts

Answer 50

CCB or thiazide diuretic

Question 50

Initial Tx: nonblack pts < 60yo (**)

Answer 50

ARB or ACE inhibitor

Question 51

Initial Tx: Pts w/ chronic kidney dz (**)

Answer 51

ARB or ACE inhibitor

Question 51

Initial Tx: Pts w/ CAD

Answer 51

BB and ARB or ACE inhibitor

Question 51

Initial Tx: w/ HF

Answer 51

ARB or ACE inhibitor & BB & spironolactone

Question 51

Initial Tx: Nonblack Pts >/= 60yo

Answer 51

CCB, thiazide diuretic, ARB or ACE inhibitor

Question 52

Initial Tx: Pts w/ DM

Answer 52

ARB or ACE inhibitor (CCB or thiazide diuretic in black pts)

Question 53

Initial Tx: w/ history of stroke

Answer 53

ARB or ACE inhibitor