Pharm chapter 6

Question 1

What is. The study of the role of inheritance in variation in drug response

Answer 1

Pharmacogenetics

Question 2

What happens. When. One nucleotide is exchanged for another at a given position

Answer 2

SNP

Question 3

What is it called when the SNP changes the encoded amino acid

Answer 3

Nonsynonymous coding (cSNP)

Question 4

What are the factors that influence the coenntrations of drug reaching its target(s)

Answer 4

Pharmacokinetics

Question 5

What is the most common factor responsible for pharmacogenetic variation in response to medications

Answer 5

Inherited variation in enzymes that catalyze drug metabolism

Question 6

Describe phase 1 reactions

Answer 6

Functionalization reactions that typically involve oxidation or reduction reactions

Question 7

Describe phase 2 reactions

Answer 7

Conjugation reactions that add groups, such as glucoronic acid, that enhance drug solubility and thus drug excretion

Question 8

What happens to patients with variations in BChE

Answer 8

Have a decreased rate of metabolism of succinylcholine, resulting in prolonged paralysis after drug exposure

Question 9

What does NAT2 do

Answer 9

Genetically polymorphic phase 2 enzyme that catalyzes the acetylation of isoniazid

Question 10

What type of phase of drug enzyme is CYP2D6

Answer 10

Phase 1

Question 11

What type of medications does CYP2D6 contribute to the metabolism of

Answer 11

Antidepressants, antiarrhythmics, and analgesics

Question 12

What is the affected drug class of CYP1A2

Answer 12

Acetaminophen, caffeine, propranolol

Question 13

What is the affected drug class of CYP1B1

Answer 13

Estrogens

Question 14

What is the affected drug class of CYP2A6

Answer 14

Halothane, nicotine

Question 15

What is the affected drug class of CYP2B6

Answer 15

Cyclophosphamide

Question 16

What is the affected drug class of CYP2C8

Answer 16

Pacilitaxel, retinoic acid

Question 17

What is the affected drug class of CYP2C9

Answer 17

Nonsteroidal anti-inflammatory drugs, phenytoin, warfarin

Question 18

What is the affected drug class of CYP2C19

Answer 18

Omeprazole, phenytoin, propranolol

Question 19

What is the affected drug class of N-acetyltransferase 1

Answer 19

Sulfamethoxazole

Question 20

What is the affected drug class of N-acetyltransferase 2

Answer 20

Dapsone, hydralazine, isoniazid, procainamide, sulfonamides

Question 21

What is the affected drug class of SULTs

Answer 21

Acetaminophen, dopamine, epinephrine, estrogens

Question 22

What is the affected drug class of thiopurine S-methyltransferase

Answer 22

Azathioprine, mercaptopurine, thioguanine

Question 23

What is the affected drug class of UDP-glucoronosyltransferases

Answer 23

Androgens, ibuprofen, irinotecan, morphine, naproxen

Question 24

What breast cancer drug is CYP2D6 genetic polymorphisms important for the efficacy of

Answer 24

Tamoxifen

Question 25

What is tamoxifen used for

Answer 25

To block the estrogen receptor in approximately 60% of breast cancer patients with ER-positive tumors

Question 26

What does TPMT do

Answer 26

Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptupurine and azathioprine

Question 27

What is the affected drug class of the protein 5-lipoxygenase

Answer 27

Zilueton

Question 28

What is the affected drug class of the protein ACE

Answer 28

ACE inhibitors

Question 29

What is the affected drug class of the protein Apolipoprotein E

Answer 29

Statins

Question 30

What is the affected drug class of the protein Epidermal growth factor receptor

Answer 30

Gefitinib

Question 31

What is the affected drug class of the protein Sulfonylurea receptor

Answer 31

Tolbutamide

Question 32

What does the medication zilueton treat

Answer 32

Asthma

Question 33

What type of mutation can occur in patients with nonsmall cell lung cancer (NSCLC)

Answer 33

Somatic DNA involving gain of functio mutations in EGFR

Question 34

What type of inhibitor is abacavir and what is it important for

Answer 34

It is a reverse-transcriptase inhibitor and is important HIV agent

Question 35

What does rofecoxib (voids) inhibitor

Answer 35

COX-2