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Flashcards in PHARM FINAL 100 Deck (58):
1

contact lens wearers eye drops

want to protect for pseudomonas

CIPRO

2

aminoglycosides = concerned about

nephrotoxicity
ototoxicity (irreversible)
neuromuscular blockade

therefore aminoglycosides are CI with myasthenia gravis

neuromuscular blockade reversed with CALCIUM GLUCONATE (also reverses magnesium sulfate)

3

fluoroquinolones = worried about

tendon rupture

higher risk with elderly > 60, patients on steroids, and patients who have had a heart / lung / kidney transplant

4

which aminoglycoside = most concerned about GI distress / diarrhea

erythromycin

5

jarisch herxheimer rxn = most often seen with

secondary syphilis treatment with PCN

6

grey baby syndrome, hemolytic anemia & aplastic anemia = seen with

chloramphenicol

because of interference with human mitochondrial ribosomes, can lead to poor feeding, depressed breathing, cardiovascular collapse, cyanosis, and death

7

red man syndrome = seen with

vancomycin

histamine release which causes flushing and pruritus

8

treatment for gonorrhea

treatment for chlamydia

gonorrhea = ceftriaxone (Rocephin) 250mg IM

chlamydia = azithromycin

9

doxycycline = worried about

GI upset; give with food

can be given in patients with renal compromise because it is cleared from bile duct to feces instead of through urine like the rest of tetracyclines

teeth staining / stunt growth of bones; so don't give to kids < 8

do not give with dairy

10

clindamycin = worried about

C. dif

Clostridium difficile is a bug that hangs out in the gut and typically causes zero problems. However, with administration of Clindamycin you can potentially have overgrowth of Clostridium difficile which can lead to a potentially fatal disease referred to as pseudomembranous colitis

11

treatment for C. dif

1st line = metronidazole

2nd line = vancomycin

12

anti-pseudomonal penicillins

piperacillin

ticarcillin

13

community acquired pneumonia treatment

azithromycin

14

lyme dz & RMSF treatment

doxy

lyme dz = doxy; if < 8 = amoxicillin

RMSF = doxy, even if a kid; pregnant = chloramphenicol

15

otitis media treatment in children

amoxicillin 90mg/kg/day BID

16

selective NSAID med

selective vs non-selective

celecoxib (Celebrex)

COX-1 and COX-2. Both enzymes produce prostaglandins that promote inflammation, pain, and fever; however, only COX-1 produces prostaglandins that activate platelets and protect the stomach and intestinal lining.

so non-selective NSAIDS = inhibit COX 1 & 2 = inhibit prostaglandins that promote inflammation / pain / fever, but also inhibit prostaglandins from COX 1 from protect stomach/intestinal lining --> ulcers

- selective NSAIDS = only COX 2 = inhibit inflammation / pain / fever, but don't inhibit COX 1, therefore doesn't inhibit stomach/intestinal lining protection - (celebrex / celecoxib) - don't get ulcers

17

BPH treatment

Flomax (tamusulosin)

alpha-1 blocker = causes peripheral vasodilation
(alpha 1 receptors cause peripheral vacoconstriction)

SE = 1st dose syncope; orthostatic hypotension

18

impetigo treatment

mupirocin (Bactroban)

19

cellulitis treatment (uncomplicated)

complicated cellulitis treatment (worried about MRSA)

uncomplicated = Keflex (cephalexin)

complicated = Vanco or Clindamycin

20

anaerobic coverage antibiotics

clindamycin & metronidazole

21

MRSA antibiotics

vancomycin
clindamycin
doxycycline
Bactrim
linezolid

22

dog/cat/human bite treatment

augmentin

23

cell wall synthesis inhibitor antibiotics

beta lactam antibiotics
- penicillins
- cephalosporins
- beta lactamase inhibitors
- carbapenem
- monobactam

24

protein synthesis inhibitor antibiotics

30S vs 50S

buy AT 30s
- aminoglycosides
- tetracyclines

CELL at 50s
- chloramphenicol
- erythromycin (all macrolides)
- Lincosamides (clindamycin)
- Linezolid

25

bacteriostatic vs bactericidal

BACTERIOSTATIC = ECSTaTiC
- Erythromycin (macrolides)
- Chloramphenicol
- Bactrim (sulfamethoxazole - trimethoprim)
- Tetracyclines
- Clindamycin

BACTERICIDAL = Very Finely Proficient At Cell Murder
- Vancomycin
- Fluoroquinolones
- Penicillins
- Aminoglycosides
- Cephalosporins
- Metronidazole

26

You should evaluate _________ function in anyone taking lithium

thyroid

27

treatment for a heparin overdose

protamine sulfate

28

reversal of benzos

flumazenil (Romazicon)

29

reversal of opioids

naloxone (Narcan)

30

max daily dose of acetaminophen

4g

31

reversal of acetaminophen overdose

acetylcysteine

32

medication associated with malignant hyperthermia

magnesium sulfate

33

torsades de pointes med

magnesium sulfate

34

reversal of magnesium sulfate

calcium gluconate

35

TB treatment

RIPE
rifampin - turns pee orange & hepatotoxicity
isoniazid - peripheral neuropathy & hepatotoxicity
pyrazinamide - gout & hepatotoxicity
ethambutol - optic neuritis, color-blindness

36

SE of rifampin

Orange body fluids
Thrombocytopenia

37

SE of ethambutol

Optic neuritis & color disturbance
Peripheral neuropathy

38

long term PPI use = associated with ______ deficiency

B12

39

gout medications


Indomethacin
Allopurinol--decreased formation & increased excretion
Probenecid--increases uric acid excretion

40

What do you co-administer with methotrexate?

folate

41

SE of bleomycin

pulmonary fibrosis

42

MC beta lactam abx associated with diarrhea

augmentin

43

respiratory fluoroquinolones

moxifloxacin
Gemifloxacin
levofloxacin

44

pseudomonas quinolones

ciprofloxacin
levofloxacin

45

DNA synthesis inhibitors (abx)

Fluoroquinolones
Metronidazole

46

folic acid synthesis inhibitors

bactrim

47

RNA synthesis inhibitor

RIfampin

48

Mycolic acid synthesis inhibitor

Isoniazid

49

which fluoroquinolone is not cleared renally, and therefore does NOT have to be adjusted with renal dysfunction

moxifloxacin

50

most ototoxic aminoglycoside

amikacin

51

which abx = worried about kernicterus with pregnancy

sulfonamides

52

metronidazole indications

trichomonas vaginalis (bacterial vaginosis)

c. dif

h. pylori (when allergic to amoxicillin)

53

BBW of metronidazole

carcinogenic in mice

54

do not give which drug with vancomycin

AMINOGLYCOSIDES
- due to enhanced effects of nephrotoxicity & ototoxicity

also don't give NSAIDS & Piperacillin with vanco

55

treatment for pericarditis

colchicine (indomethacin)

NSAIDS + ASA

56

treat HTN in black people with

CCB

57

patients with CAD & HTN should be treated with

beta blocker

58

HTN & pregnancy can be treated with

methyldopa (1st line)

hydralazine

labetalol

do NOT use ACEI/ARBs in pregnancy