PHARM FINAL 100 Flashcards
(58 cards)
contact lens wearers eye drops
want to protect for pseudomonas
CIPRO
aminoglycosides = concerned about
nephrotoxicity
ototoxicity (irreversible)
neuromuscular blockade
therefore aminoglycosides are CI with myasthenia gravis
neuromuscular blockade reversed with CALCIUM GLUCONATE (also reverses magnesium sulfate)
fluoroquinolones = worried about
tendon rupture
higher risk with elderly > 60, patients on steroids, and patients who have had a heart / lung / kidney transplant
which aminoglycoside = most concerned about GI distress / diarrhea
erythromycin
jarisch herxheimer rxn = most often seen with
secondary syphilis treatment with PCN
grey baby syndrome, hemolytic anemia & aplastic anemia = seen with
chloramphenicol
because of interference with human mitochondrial ribosomes, can lead to poor feeding, depressed breathing, cardiovascular collapse, cyanosis, and death
red man syndrome = seen with
vancomycin
histamine release which causes flushing and pruritus
treatment for gonorrhea
treatment for chlamydia
gonorrhea = ceftriaxone (Rocephin) 250mg IM
chlamydia = azithromycin
doxycycline = worried about
GI upset; give with food
can be given in patients with renal compromise because it is cleared from bile duct to feces instead of through urine like the rest of tetracyclines
teeth staining / stunt growth of bones; so don’t give to kids < 8
do not give with dairy
clindamycin = worried about
C. dif
Clostridium difficile is a bug that hangs out in the gut and typically causes zero problems. However, with administration of Clindamycin you can potentially have overgrowth of Clostridium difficile which can lead to a potentially fatal disease referred to as pseudomembranous colitis
treatment for C. dif
1st line = metronidazole
2nd line = vancomycin
anti-pseudomonal penicillins
piperacillin
ticarcillin
community acquired pneumonia treatment
azithromycin
lyme dz & RMSF treatment
doxy
lyme dz = doxy; if < 8 = amoxicillin
RMSF = doxy, even if a kid; pregnant = chloramphenicol
otitis media treatment in children
amoxicillin 90mg/kg/day BID
selective NSAID med
selective vs non-selective
celecoxib (Celebrex)
COX-1 and COX-2. Both enzymes produce prostaglandins that promote inflammation, pain, and fever; however, only COX-1 produces prostaglandins that activate platelets and protect the stomach and intestinal lining.
so non-selective NSAIDS = inhibit COX 1 & 2 = inhibit prostaglandins that promote inflammation / pain / fever, but also inhibit prostaglandins from COX 1 from protect stomach/intestinal lining –> ulcers
- selective NSAIDS = only COX 2 = inhibit inflammation / pain / fever, but don’t inhibit COX 1, therefore doesn’t inhibit stomach/intestinal lining protection - (celebrex / celecoxib) - don’t get ulcers
BPH treatment
Flomax (tamusulosin)
alpha-1 blocker = causes peripheral vasodilation
(alpha 1 receptors cause peripheral vacoconstriction)
SE = 1st dose syncope; orthostatic hypotension
impetigo treatment
mupirocin (Bactroban)
cellulitis treatment (uncomplicated)
complicated cellulitis treatment (worried about MRSA)
uncomplicated = Keflex (cephalexin)
complicated = Vanco or Clindamycin
anaerobic coverage antibiotics
clindamycin & metronidazole
MRSA antibiotics
vancomycin clindamycin doxycycline Bactrim linezolid
dog/cat/human bite treatment
augmentin
cell wall synthesis inhibitor antibiotics
beta lactam antibiotics
- penicillins
- cephalosporins
- beta lactamase inhibitors
- carbapenem
- monobactam
protein synthesis inhibitor antibiotics
30S vs 50S
buy AT 30s
- aminoglycosides
- tetracyclines
CELL at 50s
- chloramphenicol
- erythromycin (all macrolides)
- Lincosamides (clindamycin)
- Linezolid
