pharm final

Question 1

Causes vasodilation by blocking L-type calcium channels

Answer 1

Felodopine

Question 2

Movement of sodium with what phase of cardiac AP

Answer 2

Phase 0

Question 3

positive of statin

Answer 3

Improves endothelial function

Question 4

Sildenafil

Answer 4

Phosphodiesterase 5 inhibitor

Question 5

On ACE inhibitor that gives cough, what can they swith to so no cough

Answer 5

ValsartaN

Question 6

epi

Answer 6

neurotransmitter

Question 7

Drug with zero order kinetics

Answer 7

phenytoin

Question 8

Catalyzes rate limiting step

Answer 8

lovastatin

Question 9

First step in atherogenesis

Answer 9

endothelial dysfunction

Question 10

Blocks angiotensin II at At1 receptor:

Answer 10

Candesartan

Question 11

Morphine can produce diff responses in diff tissues because:

Answer 11

heterogeneity of G proteins allows diff actions on downstream effectors

Question 12

Intracellular concentration key in smooth muscle tone

Answer 12

calcium

Question 13

organ responsible for first pass?

Answer 13

liver

Question 14

depolarizing paralytic

Answer 14

succinylcholine sh

Question 15

70% of drug is bound

Answer 15

70% of drug is bound: 30% is unbound

Question 16

dose response curve when add compet antag

Answer 16

shifts right

Question 17

Inhibits COX1 preventing formation of thromboxane A?

Answer 17

Aspirin

Question 18

alpha -1 receptor =

Answer 18

ncreases sympathetic tone

Question 19

FDA definition of drug

Answer 19

intended for use in diagnosis, cure, treatment or prevention of
disease

Question 20

lipoprotein with lowest portion of triglycerides

Answer 20

HDL

Question 21

gynecomastia in men caused by

Answer 21

spironolactone

Question 22

1 transmembrane span in resting state

Answer 22

insulin receptor

Question 23

irreversible bond

Answer 23

covalent

Question 24

Prevents prothrombin to thrombin

Answer 24

factor Xa inhibitor

Question 25

.HMG co A good target because

Answer 25

rate limiting step in synthesis of cholestorl

Question 26

. Basic drug in basic PH

Answer 26

non ionized, deprotonated

Question 27

amount of drug absorbed per amount administed

Answer 27

bioavailability

Question 28

Area between min effective concentration and min toxic concentration

Answer 28

therapeutic window

Question 29

Optimal level for triglycerides?

Answer 29

<150

Question 30

Opioid receptor competitively antagonized by

Answer 30

naloxone

Question 31

Prevents conversion of prothrombin to thrombin by factor Xa =

Answer 31

factor Xa inhibitors

Question 32

Vasodilator that increases intracellular nitrci oxide concentration?

Answer 32

Sodium Nitroprusside

Question 33

Exaggerated immunological response

Answer 33

allergic reaction

Question 34

half life =

Answer 34

.693/ ke

Question 35

Arythmia >100 beats per minute

Answer 35

tachycardia

Question 36

Beta blocker

Answer 36

atenolol

Question 37

Drug must be bound to protein to elicit effect

Answer 37

true

Question 38

Beta blocker safest for severe asthma?

Answer 38

Metoprolol

Question 39

Severe cholinergic toxicity, what is atropine NOT effective in treating?

Answer 39

Paralysis

Question 40

What binds to diff site than the agonist?

Answer 40

Allosteric antagonist

Question 41

Alpha adrenergic antagonists that can occur if patient gets up to quickly from chair

Answer 41

alpha 1 | blockade: orthostatic hypotension

Question 42

Side effect of hair growth

Answer 42

minoxidil

Question 43

Lipoprotein lipase is what role in exogenous pathway?

Answer 43

Metabolized chylomicrons to release triglycerides

Question 44

MTC

Answer 44

minimum toxic concentration

Question 45

Ligand binding domain on the inside of cells-

Answer 45

steroid receptors

Question 46

Plasma proteins are good targets for:

Answer 46

monoclonal antibodies

Question 47

Testosterone induces:

Answer 47

gene transcription and translation to increase protein synthesis

Question 48

Dry mouth and sedation

Answer 48

Diphenhydramine (benadryl)

Question 49

Insulin receptors form homodimers that phosphorylat intracellular proteins at sites containing

Answer 49

tyrosine

Question 50

alpha agonist can be used as nasal decongestant and for short term hypotension

Answer 50

phenylephrine

Question 51

IV doses, bioavailability =

Answer 51

100%

Question 52

Positive pleiotropic effect of statins

Answer 52

improved endothelial function

Question 53

Medication inhibits the final common pathway in platelet aggregation

Answer 53

eptifibatide

Question 54

Aspirin overdose, to get it to leave you

Answer 54

alkalinize the urine

Question 55

myocardial oxygen demand determinant

Answer 55

heart rate

Question 56

Which is not an NOAC

Answer 56

warfarin

Question 57

Weak base trapped in ___ weak acid in ____?

Answer 57

Acidic, alkaline

Question 58

sympathetic, post ganglion neuron release

Answer 58

norepi

Question 59

7 transmembrane receptor

Answer 59

opioid mu receptor

Question 60

acidic drug, acidic ph - non ionized, protonated

Answer 60

acidic drug, acidic ph - non ionized, protonated

Question 61

Beta 2 adrenergic receptors

Answer 61

- triggers bronchodilation

Question 62

1994 DSHEA :

Answer 62

prohibited full FDA review on supplements and botanicals as drugs

Question 63

Quaternary amine:

Answer 63

glycopyrrolate