Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Repro Flash Cards > Pharm: GU and Prostate Drugs > Flashcards

Pharm: GU and Prostate Drugs Flashcards

(64 cards)

Start Studying
1
Q

Finasteride is in what drug class?

A

5 alpha reductase inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is Finasteride used for?

A

2nd line drug to treat mod to severe BPH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

How does finasteride work?

A
  • Reduces static factor
  • induces apoptosis of glandular cells which then reduce prostate size
  • inhibits Type II alpha reductase, interfering with conversion of testosterone to 5 alpha dihydrotestosterone
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the common s/e of using finasteride

A 
Impotence
decreased libido
orthostatic hypotension
abnormal ejaculation
sexual dysfunciton
gynecomastia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Does finasteride have adverse CV effects?

A

Nope

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Contraindications of using finasteride for BPH

A

don’t handle the drug if pregnant because the drug has the potential to cause feminization of the male fetus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Does finasteride have a slower or faster onset than Tamulosin?

A 
Slower onset (up to 6 months) 
can use concurrently to produce rapid systematic improvement
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Why do you need to obtain a baseline PSA level when starting finasteride?

A

Because it produces a 50% reduction of [PSA]

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the drug class for Tamulosin?

A

alpha1 adrenergic antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the DOC for BPH?

A

Tamulosin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How does Tamulosin work?

A
  • It acts to reduce the dynamic factor in urinary tract outflow by neurologic inhibition
  • It selectively antagonizes prostate alpa 1 a adrenergic receptors, relaxing smooth muscle and improving urine flow
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is tamulosin indicated for?

A

Mod to Severe BPH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

The common side effects of using Tamulosin are what?

A

Retrograde ejaculation with 0.8mg dosing

Dizziness, syncope, infection, somnolence, decreased libido

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Where is Tamulosin metabolized?

A

In the liver - metabolized by CYP3A4 and CYP2D6 enzyme systems

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Does Tamulosin act slowly or quickly?

A

quickly! within 1 - 2 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What do you need to remember about Tamulosin and the eye?

A

If using prior to cataract sx, can cause floppy iris syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

When taking Tamulosin with a PDE5 inhibitor, how long do you need to wait after administering one before the other?

A

4 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is an herbal supplement that can be used for treatment of BPH?

A

Saw Palmetto

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

MoA of saw palmetto

A

shrinks inner lining of prostate gland that puts pressure on the urethra

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Is saw palmetto currently recommended?

A

Nope

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What two medications are used for the treatment of prostate cancer?

A

Leuprolide

Flutamide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What is the MoA of Leuprolide?

A

Agonist of both gonadotropin releasing hormone (GnRH) and leutenizing hormone receptor hormone (LHRH)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What is Leuprolide used for?

A

Palliative treatment of prostate cancer

Endometriosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

A common drug drug interaction with leuprolide is what?

A

Anti-diabetic medications

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
What is something that you need to know when taking leuprolide?
May cause a tumor flare after 2 weeks which includes bone pain, neuropathy, bladder outlet obstruction due to 2ndary increase in serum testosterone
26
Overall, does leuprolide increase or decrease testosterone?
Reduces testosterone levels to below castration levels
27
Flutamide has an MoA of what?
Non-steroidal anti-androgen that inhibits androgen binding in target tissues
28
Indications for Flutamide are what?
Metastatic prostate cancer with LHRH agonist
29
What are some common S/E of using flutamide?
``` Gynecomastia Hot flashes galactorrhea impotence possible liver failure ```
30
When do you not want to use flutamide?
severe hepatic impairment | G6PD deficiency
31
How much does the use of flutamide and leuprolide increase cancer survival rate?
7 months
32
Testosterone is used what what?
Hypogonadism
33
What are common S/E of Testosterone
``` prostate hypertrophy emotional liability altered libido Increased risk of hepatitis DVT HTN Agression acne ```
34
Contraindications of Testosterone
Serious hepatic, renal, cardiac disease
35
What are common dx dx interactions with using testosterone
increased effectiveness of Vitamin K antagonists (warfarin)
36
What is the tricyclic antidepressant used for treatment of urinary incontinence?
Imipramine
37
The MoA of imipramine is what?
Increases synaptic concentrations of serotonin and NE which down regulated beta adrenergic receptors and an anti-cholinergic effect on detrusor muscle of bladder
38
What are common s/e of imipramine
Sedation Anticholinergic effects (can't see, can't pee, can't spit, can't shit) Orthostatis Impotence
39
Is imipramine a first line drug for UI?
No. It has a lot of S/E and drug interactions
40
Should you use imipramine in the elderly?
Not really
41
Tolterodine is what drug class?
Anti-cholinergic agent
42
What is the MoA of tolterodine?
selective antagonist of bladder muscarinic receptors which then decrease detrusor muscle pressure in bladder to increase residual urine volume
43
What are the indications for tolterodine?
Overactive bladder and urge incontinence
44
Common s/e of tolterodine?
Anti-cholinergic effects | HA, diarrhea, arthralgia, QT prolongation
45
When do you not want to use tolterodine?
Pre-existing urinary retention Gastric retention Narrow angle glaucoma
46
Oxybutinin is in what drug class?
Anticholinergic agent
47
The MoA of oxybutinin is what?
Same as tolterodine (selective antagonist of bladder muscarinic receptors which then decrease detrusor muscle pressure in bladder to increase residual urine volume)
48
What are some added contraindications for using oxybutinin for UI compared to tolterodine?
Hyperthyroidism GERD Ulcerative cholitis
49
What drug may increase the concentration of Oxybutinin?
Pramlintide (anti diabetic drug)
50
Oxybutinin may decrease the effectiveness of what drug?
Doneprezil (alzheimer medication)
51
What are the 2 drugs used to treat erectile dysfunction?
Sildenafil (Viagra) | Tadalafil (cialis)
52
The MoA of Sildenafil and Tadalafil is what?
Inhibits PDE5 to increaesd concentration of nitric oxide leading to corpus cavernosum relaxation and inflow of blood to cause erection
53
Indications for Sildenafil and Tadalafil are what?
ED | Pulmonary artery hypertension
54
What are common s/e of PDE5 inhibitors?
``` dyspepsia flushing diarrhea color vision changes hypotension angina arrythmias ```
55
Drugs that should not be taken with PDE5 inhibitors are what?
Nitrates!! Also, anti-HTN Grapefruit juice
56
Considerations of taking PDE5 inhibitors when it comes to length of erection
If >4 hours, go to hospital so epinphrine can be injected into penis and counteract parasympathetic effect --> flaccidity
57
What is an added consideration when it comes to using this substance and Tadalafil?
Avoid high doses of EtOH with Tadalafil use
58
Is the half life of Tadalafil or Sildenafil longer?
Tadalafil is longer (15-17.5 hours) so it can be taken daily at a lower dose
59
Mirabegron is used for what?
Overactive bladder withs/s of urinary frequency, urgency, Urge UI
60
What is the MoA of Mirabegron?
Activate beta 3 adrenergic receptors in bladder resulting in relaxation of detrusor muscle during urge storage phase thus increasing bladder capacity
61
Common S/E of Mirabegron include what?
HTN | Angioedema of face, tongue, lips, larynx
62
Contraindications of Mirabegron
- Use with caution in patients with BOO due to increased risk of Urinary retention - Chronic uncontrolled HTN
63
What are dx dx interactions that should be considered with use of Mirabegron?
Anticholinergic agents may enhance ADRs of the drug Rifampin may increase concentration of drug Anticholinergic meds in this module: Tolterodine and oxybutinin
64
Are dose adjustments necessary with Mirabegron in the elderly?
Yes

Repro Flash Cards (2 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions