Pharm I - Fleckenstein Flashcards Preview

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Flashcards in Pharm I - Fleckenstein Deck (22):
1

Define Pharmacokinetics

Actions the body has ON the drug

2

Define Pharmacodynamics

Actions the drugs has ON the body

3

Describe an Agonist

-A natural drug or Ligand -Activates receptor

4

This is usually competes with the agonist with the binding site but does not activate the receptor

Antagonist (competitive inhibitor)

5

In what direction does the antagonist usually shift the dose response curve?

To the right

6

Describe an allosteric inhibitor

Binds to different site than agonist and antagonist. NONCOMPETITIVE And creates conformational change to receptor as to agonist can no longer bind

7

What is a full agonist

High affinity for Ra. Ra-D complex favored, Larger effect observed

8

Partial agonist

Intermediate affinity for Ra and Ri. Ra-D not stabilized as well than in Full agonist

9

Inverse agonist

Higher affinity for Ri. DON'T confuse with Antagonist. Reduce constitutive activity

10

What is a conventional antagonist

Equal affinity for Ra and Ri NO CHANGE in constitutive activity

11

Which of the following drug receptor interaction has a net effect GREATER than the sum -Additive -Synergistic -Antagonistic

SYNGERSITIC (1+1 = 5) Additive - 1+1 = 2 Antagonistic 1+1 = 0.5

12

This antagonist does not involve a receptor, a good example is a protein disrupting pH counteracting the effects of the drug

Chemical antagonist

13

Define Efficacy

Number of receptos that must be activated to yeild max response

14

How is potency different than efficacy?

Efficacy refers to the number of receptors where as potency refers to the amount of the drug needed. So a POTENT drug would require little dosage to illicit a max response.

15

This is a measure of the drug's ability to produce a change in cellular activity

Intrinsic activity

16

This is a measure of the Tightness that a drug BINDS to the receptor

Affinity

17

Define Therapeutic index

TI = TD(50)/ED(50) You want a large Toxic does over a small effective dose

18

Define margin of safety

T.D (1%) / E.D. (99%)

19

What is the fastest mode of mode of dosage for drugs

Intravenous or (Parenteral)

20

Oral or Rectal administration is an example of .........

Enteral (by way of intestine)

21

What is a disadvantage of oral administration (enteral)

Most unpredictable

22

Which line is the most potent 

Q image thumb

Line B