PHARM M01-FL01 Behavior Modifying Drugs (flashcards)

Question 1

The major neurotransmitter targeted for behavior modifying drugs

Answer 1

serotonin

Question 2

The receptor type targeted by behavior modifying drugs that act at serotonin

Answer 2

5-HT (1-5)

Question 3

These catecholamines may also be targeted by behavior modifying drugs

Answer 3

Norepineprhine, epinephrine

Question 4

Most behavior modifying drugs are inhibitory in nature: True or False

Answer 4

False (most result in stimulatory actions)

Question 5

Of the neurotransmitters targeted by CNS drugs, the one that is most likely to be inhibitory in nature

Answer 5

GABA (gamma amino butyric acid).

Question 6

The abnormal behavior indicated for behavior modifying drugs approved for use in dogs or cats.

Answer 6

separation anxiety

Question 7

Adaptation of the brain to behavior modifying drugs may result in these to phenomena

Answer 7

Tolerance and physical dependence (which may lead to withdrawal)

Question 8

The term used to refer to the need for higher drug concentrations to produce the same response

Answer 8

tolerance

Question 9

The term used to refer to the state in which rapid discontinuation of a drug may lead to clinical signs of withdrawal

Answer 9

Physical dependance

Question 10

A common, extralabel indication for behavior modifing drugs in dogs and cats.

Answer 10

obsessive compulsive disorders, urinary spraying

Question 11

Drugs which induce sedation or calmness without sleep

Answer 11

tranquilizers

Question 12

Tranquilizers which alter behavior or response to environment

Answer 12

neuroleptics

Question 13

The receptors targeted by tranquilizers

Answer 13

dopamine-2

Question 14

Acepromazine is a high or low potency tranquilizer (choose one)?

Answer 14

low

Question 15

Non-dopamine receptors targeted (blocked) by acepromazine that may cause hypotension

Answer 15

alpha (1 more than 2)

Question 16

Non-dopamine receptors targeted (blocked) by acepromazine that contribute to sedation

Answer 16

histamine

Question 17

Phenothiazines worsen seizures: yes, no or its controversial

Answer 17

its controversial

Question 18

This behavior may be worsened by acepromazine

Answer 18

aggression

Question 19

The sole behavior disorder for which acepromazine might be used to treat in animals

Answer 19

anxiety

Question 20

Antidepressants are CNS stimulants: true or false

Answer 20

TRUE

Question 21

Clomipramine belongs to what class of behavior modifying drug?

Answer 21

Tri-cyclic antidepressants

Question 22

The primary neurotransmitter targeted by clomipramine

Answer 22

serotonin

Question 23

Two reasons why the effects of behavior modifying drugs may be characterized by a lag time.

Answer 23

Time to steady-state, CNS adaptation

Question 24

Drugs with a short half-life should not be rapidly discontinued because of this concern.

Answer 24

Physical dependance

Question 25

The dose of behavior modifying drugs is generally the same among most species: True or False

Answer 25

That's a big negatory

Question 26

This characteristic balances the potential disadvantage of first pass metabolism

Answer 26

metabolites are active

Question 27

This characteristic of metabolites often results in longer duratio nof effect of a drug

Answer 27

half-life that is longer than the parent

Question 28

the half-life of clomipramine and its metabolite in dogs

Answer 28

about 9 hrs

Question 29

A drug approved for use in dogs to treat separation anxiety

Answer 29

clomipramine, fluoxetine

Question 30

The volume of distribution of behavior modifying drugs is large or small? Choose one

Answer 30

Large, indeed, very large.

Question 31

Side effects of TCA in general, but less so for clomipramine, because autonomic receptors are targeted

Answer 31

cardiovascular

Question 32

All CNS stimulants increase the risk of this adversity

Answer 32

seizures

Question 33

The class of drugs to which fluoexitine belongs

Answer 33

Selective serotonin re-uptake inhibitor

Question 34

The half-life of fluoxetine in dogs

Answer 34

about 6 hrs

Question 35

The half-life of norfluoxetine in dogs

Answer 35

about 50 hrs

Question 36

The half-life of fluoxetine and its metabolite in dogs

Answer 36

35 hrs

Question 37

The lag time that characterizes fluoxetine

Answer 37

about 2 weeks

Question 38

Behavior modifying drugs are generally subject to the impact of drug metabolizing enzyme inducers or inhibitors: true or false

Answer 38

TRUE

Question 39

This behavior modifying drug may inhibit drug metabolizing enzymes

Answer 39

fluoxetine, trazodone

Question 40

A behavior modifying drug whose extralabel indication is anxiety in intensive care

Answer 40

trazodone

Question 41

The mechanism of action of deprenyl (seligiline)

Answer 41

monoamine oxidase inhibitor, B

Question 42

The target neurotransmitter for cognitive disorders associated with geriatric dementia

Answer 42

dopamine