Pharm- Micro

Question 1

NRTI

Answer 1

Inhibit nucleotide Binding to reverse transcriptase

they lack 3’ OH group

Question 2

Oseltamivir (Ivir)

Answer 2

Inhibit neuraminidase decreasing progeny virus

Question 3

Acyclovir (CLOVIR)

Answer 3

Guanosine analog

DNA POLIMERASE

Question 4

Antiviral used in herpes zoster

Answer 4

Famciclovir

Question 5

Foscarnet

Answer 5

DNA/ RNA POL doesn’t need to be activated

PyroFOSfate analog

Question 6

Protease inhibitor (NAVIR)

Answer 6

Virion depends on HIV protease

Question 7

Enfuvirtide

Answer 7

Inhibit gp41 (Fusion)

Question 8

Maraviroc

Answer 8

Binds CCR5 inhibiting interaction with gp120

Question 9

Amphotericin B

Answer 9

Ergosterol binding. Forms a pore

Question 10

Treatment for cryptococcus meningitis

Answer 10

Flucytosine

Question 11

Azoles

Answer 11

Inhibit ergosterol blocking P-450

Question 12

Terbinafine

Answer 12

Inhibit squalene epoxidase

Question 13

Griseofulvine

Answer 13

Microtibule formation

Question 14

Caspofungin

Answer 14

Synthesis of B- glucan

Question 15

Toxoplasmosis treatment

Answer 15

Pyrimethamine

Question 16

1 Permethrin
2 Malathion
3Lindane

Answer 16

1 Na channel deactivate (depolarized membrane)
2 acetylcholinesterase inhibitor
3 GABA channels

Question 17

Chloroquine

Answer 17

Blocks heme detox so becomes toxic

Question 18

Penicillin

Answer 18

Block of cross- linking peptidoglycan

Question 19

Treatment for S. Aureus not MRSA

Answer 19

Dickoxacillin. Nafcillin

Question 20

Cefepime

Answer 20

Enhances activity vs pseudomonas

Question 21

Cephalosporins

Answer 21

Inhibit cell wall synthesis