pharm Qs bank

Question 1

which method avoids first pass metabolism?

Answer 1

sublingual

Question 2

how is salbutamol given?

Answer 2

inhalation

Question 3

which drug is totally metabolised in first pass metabolism?

Answer 3

GTN (glyceryl trinitate)

Question 4

a quaternary ammonium compound can only be deliverd by the following route:

Answer 4

intravenous

Question 5

which of the following statements concerning atropine is false?

Answer 5

paralyses skeletal muscle

Question 6

the alpha adrenergic receptor antagonist phentolamine causes which one of the following effects:

Answer 6

fall in blood pressure in pheochromocytoma

Question 7

which is a selective alpha-1 antagonist?

Answer 7

prazosin

Question 8

which is an acetylcholine antagonist?

Answer 8

benztropine

Question 9

what is the action of salbutamol?

Answer 9

bronchodilation

Question 10

what is an adrenoceptor neurone blocker?

Answer 10

used as hypertensive drugs

Question 11

which of the following is incorrect:

Answer 11

all ionised drugs are lipid soluble

Question 12

what is the ration of distribution of aspirin across biological membrane?

Answer 12

9900:01:00

Question 13

which drug can be absorbed from the stomach?

Answer 13

aspirin

Question 14

what do acidic drugs bind to?

Answer 14

albumin

Question 15

what do basic drugs bind to?

Answer 15

albumin and alpha-acid glycoprotein

Question 16

in which process is there the introduction of groups so that is can undergo phase 2 reactions?

Answer 16

functionalisation

Question 17

what does conjugation reactions involve?

Answer 17

generally increase in rate of excretion

Question 18

name a drug that can proceed without phase 1 reaction?

Answer 18

temazepam

Question 19

an usual site of excretion

Answer 19

sweat

Question 20

which is not the fator that affects drug concentration in blood plasma?

Answer 20

conjugation

Question 21

what is the loading dose?

Answer 21

given at the beginning of treatment as one big dose

Question 22

which is not a factor of multiple dosing (long 0.5t)?

Answer 22

hard to maintain in therapeutic window

Question 23

which is not a factor of multiple dosing (short 0.5t)?

Answer 23

small fluctuations between doses

Question 24

ionisation affects

Answer 24

distribution

Question 25

which is not a structure of quarternary ammonium ions?

Answer 25

R group is not an aryl group

Question 26

the ANS can be:

Answer 26

excitatory or inhibitory

Question 27

the ANS is controlled by:

Answer 27

None of the above

Question 28

the SNS can be:

Answer 28

excitatory only

Question 29

the SNS is controlled by

Answer 29

cerebrum

Question 30

what do SNS terminals produce?

Answer 30

acetylcholine

Question 31

what do ANS terminals produce?

Answer 31

noradrenaline and acetylcholine

Question 32

which divisions of the hypothalamus has direct parasympathetic innervations?

Answer 32

anterior and medial regions

Question 33

which divisions of the hypothalamus has direct sympathetic innervations?

Answer 33

lateral and posterior regions

Question 34

which is not a muscarinic agonist?

Answer 34

BDZ

Question 35

Which is an adverse effect of alpha-2 adrenergic agonists?

Answer 35

hypotension

Question 36

which is not an anti- muscarinic effect?

Answer 36

tremors

Question 37

which is not a property of pyridostigmine?

Answer 37

tertiary ammonium

Question 38

which cranial nerve is not involved in parasympathetic innervations?

Answer 38

trigeminal

Question 39

what is the function of occulomotor nerve?

Answer 39

innervates four extrinsic muscles of the eye

Question 40

what is the function of facial nerve?

Answer 40

innervates facial expression muscles

Question 41

suxamethonium

Answer 41

is a depolarising blocker at neuromuscular junction end-plate

Question 42

which of the following statements is correct?

Answer 42

physiological antagonism is exhibited by salbutamol in asthma

Question 43

the mechanism of action of ipratropium in the treatment of asthma is:

Answer 43

inhibition of the effect of the vagus

Question 44

which of the following statements is correct?

Answer 44

histamine release from mast cells stimulates H2 receptors on the parietal cell

Question 45

what is the mode of action of ipratropium?

Answer 45

anticholinergic drug

Question 46

which is not a property of pyridostigmine?

Answer 46

tertiary ammonium

Question 47

what is the function of glossopharyngeal nerve

Answer 47

innervates tongue and pharynx

Question 48

what produce acetylcholine neurotransmitter?

Answer 48

choline acetyl transferase (CAT)

Question 49

excess production of acetylcholine neurotransmitter doesn't result in:

Answer 49

stimulation of respiratory and cardiovascular centres

Question 50

NM junctions function by

Answer 50

sodium-potassium channel

Question 51

the M1/M3/M5 receptors function by

Answer 51

phospholipase C

Question 52

the M2/M4 receptors function by

Answer 52

cAMP

Question 53

which cranial nerve innervates parotid salivary gland?

Answer 53

glossopharyngeal

Question 54

which cranial nerve innervates parotid, iris radial muscle, and ciliary muscle?

Answer 54

occulomotor

Question 55

which is the cofactor for dopa beta- hydroxylase?

Answer 55

Ascorbate

Question 56

selective agonists of alpha-1 > alpha 2?

Answer 56

phenylephrine

Question 57

selective agonists of alpha-2> alpha 1?

Answer 57

clonidine

Question 58

selective agonists of beta-1= beta-2?

Answer 58

dobutamine

Question 59

what is the resting membrane potential?

Answer 59

-60 to -90mV

Question 60

where does acetylcholine neurotransmitter get broken down?

Answer 60

synaptic basal lamina

Question 61

selective agonists of alpha-1, alpha-2, and beta-1?

Answer 61

noradrenaline

Question 62

how does hemicholinium function?

Answer 62

competes with choline transporter for uptake

Question 63

how does botulinum toxin function?

Answer 63

inhibits fusion of vesicles at pre-synaptic membrane

Question 64

how does streptomycin/ tetracycline function?

Answer 64

calcium channel blocker

Question 65

how does Black widow spider function?

Answer 65

promotes exocytosis

Question 66

which is an example of competitive non depolarising antagonist?

Answer 66

tubocurare

Question 67

which is not a side effect of depolarising blocker?

Answer 67

inhibits potassium release

Question 68

which is not a clinical function of NMJ blockers?

Answer 68

hypothermia

Question 69

which is eMax?

Answer 69

max effect

Question 70

pAx values can only be determined for

Answer 70

competitive antagonists