Pharm Quiz 1

Question 1

What is dose response relationship?

Answer 1

No response if dose is too low

Question 2

What is it called when the response plateaus

Answer 2

Maximal efficacy or ceiling effect

Question 3

What is potency

Answer 3

The dose that causes a specific response in a specific magnitude

Question 4

When a drug causes the response at a lower dose it means it is more or less potent ?

Answer 4

More potent

Question 5

What is quantal D-R curve ?

Answer 5

Determine dose that causes a specific response in group of subjects and determine drug safety

Question 6

What two things does quantal Q-R curve measure

Answer 6

Median effective dose (ED50)
median toxic dose (TD 50)

Question 7

What is median effective dose ?

Answer 7

Dose that causes beneficial effect in half the sample

Question 8

What is median toxic dose

Answer 8

Dose that causes toxic effect in half the sample

Question 9

Two analgesic medications are compared and it is found that 10 mg of drug A reduced headache pain by 50% but it takes 60 mg of drug B to cause a similar effect. We conclude that

Answer 9

Drug A is more potent

Question 10

What is ADME

Answer 10

Absorption
Distribution
Metabolism
Excretion

Question 11

What is absorption

Answer 11

When the drug must move from sit of administration into another tissue

Question 12

What are eternal routes of administration

Answer 12

Oral
Lingual
Sublingual
Buccal
Rectal

Question 13

What are parenteral routes of administration

Answer 13

Injection
Inhalation
Topical
Transdermal

Question 14

What is bioavailability

Answer 14

The percent of the administered dose that appears in the bloodstream

Question 15

What is the first pass effect

Answer 15

If the drug is administered orally, some is destroyed in the liver

Question 16

What is drug distribution

Answer 16

When the drug crosses membranes and tissues to reach target site

Question 17

What is drug distribution effected by

Answer 17

Administration route
Physiocochemical properties
Binding to plasma proteins
Barriers and carriers

Question 18

What are primary drug storage sites

Answer 18

Fat, muscle, bone, liver, kidneys

Question 19

What is the primary problem of storage

Answer 19

Local tissue damage
Redistribution

Question 20

What is the primary site of metabolism

Answer 20

The liver

Question 21

What are phase 1 rxns

Answer 21

Oxidation, reduction, hydrolysis

Question 22

What are phase 2 rxns

Answer 22

Conjunction

Question 23

What is the primary sister of excretion

Answer 23

The kidneys

Question 24

What is drug clearance

Answer 24

The rate the drug can be removed completely from the body

Question 25

What 2 variables does clearance depend on

Answer 25

Blood flow to the organs Extraction ration

Question 26

When will a drug clear best

Answer 26

If an organ has high blood flow

Question 27

What is half life ?

Answer 27

Amount of time required for 50% of the active form of the drug to be eliminated

Question 28

What is aspirin half life

Answer 28

2-3 hrs

Question 29

T/f: drugs given continuously can maintain a fairly stable level of drug in the blood stream

Answer 29

True

Question 30

T/f: drugs given intermittently will cause leaks and troughs in plasma levels

Answer 30

True

Question 31

Why should a PT take a med history

Answer 31

May be the primary care Dr

Question 32

What are analgesics

Answer 32

Opioids Non opioids

Question 33

What are anti inflammatory agents

Answer 33

NSAIDS Glucocorticoids

Question 34

What do opioids do?

Answer 34

Alter pain perception

Question 35

What are common opioids

Answer 35

Codeine Fentanyl Hydrocodone Oxycodone

Question 36

What are strong agonist opioids

Answer 36

Morphine Meperidine Fentanyl

Question 37

What are moderate agonist opioids

Answer 37

Codeine Oxycodone

Question 38

What are opioid antagonists

Answer 38

Naloxone Naomefene