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I&D Quiz 2 > Pharm (Quiz 2) > Flashcards

Pharm (Quiz 2) Flashcards

(52 cards)

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1
Q

Herpesevirus drugs

A

acyclovir, ganciclovir, foscarnet (Herpesevirus)

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2
Q

Deoxyguanosine (dG) analog

A

acyclovir, ganciclovir (Herpesevirus)

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3
Q

Phosphorylated by viral thymidine kinase (TK)

A

acyclovir, ganciclovir (Herpesevirus)

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4
Q

Preferential incorporation by viral DNA polymerase

A

acyclovir, ganciclovir (Herpesevirus)

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5
Q

causes chain termination

A

acyclovir (Herpesevirus)

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6
Q

primary/chronic HSV/VZV infections

A

acyclovir (Herpesevirus)

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7
Q

CMV (Cytomegalovirus), Less so for HSV/VZV

A

Ganciclovir (Herpesevirus)

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8
Q

Generally well tolerated

A

acyclovir, ganciclovir (Herpesevirus)

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9
Q

bone marrow suppression

A

Ganciclovir (Herpesevirus)

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10
Q

activated by HSV/VZV thymidine kinase (TK)

A

acyclovir (Herpesevirus)

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11
Q

activated by HSV/VZV TK or CMV UL97 kinase

A

Ganciclovir (Herpesevirus)

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12
Q

Drug effective only in infected cells

A

acyclovir, ganciclovir (Herpesevirus)

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13
Q

Mutation in viral thymidine kinase or viral DNA polymerase (vPol)

A

acyclovir, ganciclovir resistance (Herpesevirus)

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14
Q

Pyrophosphate Analog

A

Foscarnet (Herpesevirus)

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15
Q

Binds to pyrophosphate site of viral polymerase (also RTase)

A

Foscarnet (Herpesevirus)

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16
Q

100-fold greater selective inhibitor of viral versus human polymerase

A

Foscarnet (Herpesevirus)

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17
Q

Acyclovir/ganciclovir resistant HSV/CMV

A

Foscarnet (Herpesevirus)

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18
Q

Hypocalcemia and CNS toxicity, Precipitates out Ca2+ and forms foscarnet-Ca2+ crystals

A

Foscarnet (Herpesevirus)

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19
Q

Nephrotoxicity

A

Foscarnet (Herpesevirus)

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20
Q

Mutation in viral DNA polymerase (vPol)

A

Foscarnet (Herpesevirus)

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21
Q

Hepatitis C drugs

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A

paritaprevir, ledipasvir, ombitasvir, sofosbuvir (Hepatitis C)

22
Q

Influenza drugs

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A

oseltamivir, amandatine, baloxavir (Influenza)

23
Q

Coronavirus drug

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A

remdesivir (Coronavirus)

24
Q

Neurominidase inhibitor

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A

oseltamivir (influenza)

25
Blocks release of influenza virus from infected cells
oseltamivir (influenza)
26
Treat influenza A and B
oseltamivir, baloxavir (influenza)
27
Binds viral M2 protein that functions as an ion channel
amandatine (influenza)
28
Prevents acidificaiton of viral core
amandatine (influenza)
29
Blocks uncoating of virus in host cell
amandatine (influenza)
30
Central nervous system toxicity
amandatine (influenza)
31
Only treat influenza A; | Resistant strains has limited use
amandatine (influenza)
32
Binds influenza PA protein and inhibits cap-dependent endonuclease activity
amandatine (influenza)
33
Inhibits intiation of influenza RNA synthesis
amandatine (influenza)
34
Inhibits Hepatitis C protease NS3/NS4A
Paritaprevir (Hepatitis C)
35
Prevents processing of HCV polyprotein
Paritaprevir (Hepatitis C)
36
Inhibits Hepatitis C NS5A phosphoprotein required for viral RNA synthesis and assembly
ledipasvir, ombitasvir (Hepatitis C)
37
Inhibits Hepatitis C RNA polymerase NS5B
sofosbuvir (Hepatitis C)
38
Blocks viral DNA synthesis
acyclovir, ganciclovir (Herpesevirus)
39
Inhibits viral DNA polymerase and incorporates into DNA causing chain termination
acyclovir (Herpesevirus)
40
Requires activation by viral "thymidine kinase"
acyclovir, ganciclovir (Herpesevirus)
41
HSV/VZV treatment
acyclovir (Herpesevirus)
42
Bone marrow depression
ganciclovir (Herpesevirus)
43
CMV treatment
ganciclovir (Herpesevirus)
44
Less selective for viral enzyme so more toxic than acyclovir
ganciclovir (Herpesevirus)
45
Inhibits viral DNA polymerase activity
foscarnet (Herpesevirus)
46
Binds pyrophosphate site of viral enzyme
foscarnet (Herpesevirus)
47
Does NOT require kinase activation
foscarnet (Herpesevirus)
48
Hypocalcemia; Can lead to seizures
foscarnet (Herpesevirus)
49
Alternative when ganciclovir fails or acyclovir-resistant
foscarnet (Herpesevirus)
50
Delayed viral RNA chain termination at postion +3
remdesivir (Coronavirus)
51
Triphosphate form incorporated into viral RNA by RNA dependent RNA polymerase
remdesivir (Coronavirus)
52
Prodrug; Used for adult and pediatric COVID patients requiring hospitalization
remdesivir (Coronavirus)

I&D Quiz 2 (3 decks)

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