Pharm Quiz 3

Question 1

SIG E CAPS

Answer 1

Sleep
Interest
Guilt
Energy
Concentration
Appetite
Psychomotor retardation
Suicide/Sex

Question 2

CYP2D6 metabolizes which antidepressants?

Answer 2

TCA, SSRI, SNRI (except desvenlafaxine)

Question 3

Which drug used to help taper off SSRI?

Answer 3

fluoxetine

Question 4

overdosed, cardiac arrested, died

Answer 4

TCA

Question 5

wrong food, stroke, died

Answer 5

MAOI

Question 6

overslept, gaining weight

Answer 6

mirtazapine

Question 7

some good, more better, dies

Answer 7

bupronion

Question 8

TCA 3

Answer 8

imipramine, doxepin, amitryptaline

Question 9

Mechanism of tertiary TCA?

Answer 9

Targets serotonin and NE

Question 10

Mechanism of secondary TCA?

Answer 10

NE target

Question 11

Major SE of TCA?

Answer 11

delirium in old people, cardiac arrythmias

Question 12

toxicity treatment for TCA?

Answer 12

sodium bicarb

Question 13

Toxicity tx for SSRI?

Answer 13

Cyproheptadine

Question 14

SNRI examples

Answer 14

venlafaxin, desvenlafaxine, duloxetine

Question 15

MAOI examples

Answer 15

Isocarboxazid, tranylcypromine, phenelzine, selegiline

Question 16

SE of MAOI?

Answer 16

Orthostatic HTN

Question 17

Phenelzine (MAOI) SE?

Answer 17

hepatic necrosis

Question 18

Tyramine (MAOI) SE?

Answer 18

HTN

Question 19

Mirtazpine mech?

Answer 19

alpha 2 receptor antagonist, increases release of NE and serotonin

Question 20

Bupropion major SE?

Answer 20

seizures

Question 21

Dopamine wins out in

Answer 21

Mesolimbic, tuberhypophyseal

Question 22

Nigrostriatal dopamine SE?

Answer 22

4 hours: dystonia
Parkinsonism
Akthisia
Tardive dyskinesia

Question 23

relationship between dopamine and prolactin?

Answer 23

opposite

Question 24

Which neuroepiletics block D2 preferentially

Answer 24

Chlorpromazine, Haloperidol

Question 25

Which neuroepileptics block D2 AND Serotonin receptors?

Answer 25

Clozapine, Risperidone, Aripiprazole

Question 26

Metabolism of Chlorpromazine, Haloperidol, Clozapine, Risperidone, Aripiprazole

Answer 26

``` 2D6 2D6, 3A4 1A2, 2D6, 3A4 2D6 2D6, 3A4 ```

Question 27

SE of Chlorpromazine

Answer 27

obstructive jaundice

Question 28

SE of haloperidol?

Answer 28

QT prolongation

Question 29

SE of Clozapine?

Answer 29

agranulocytosis

Question 30

SE of Risperidone?

Answer 30

weight gain

Question 31

Sodium channel blockers for epilepsy?

Answer 31

Carbamazepine, Phenytoin, Oxcarbazepine, Lamotrigine

Question 32

GABA receptor agonist for epilepsy?

Answer 32

Benzodiazepine, Barb (phenobarbital)

Question 33

Which epilepsy treatments induce p450?

Answer 33

Carbamazepine, phenytoin, Barb (phenobarbital)

Question 34

Felbamate mech?

Answer 34

antiepilepsy, targets NMDA glutamate

Question 35

Tiagabine mech?

Answer 35

antiepilepsy, kainate receptors

Question 36

T calcium current suppresor?

Answer 36

Ethosuximide

Question 37

Binds alpha 2 delta subunit of Ca channels?

Answer 37

Gabapentin, Pregbalin

Question 38

Presynpaptic protein SV2A on synaptic vesicles?

Answer 38

Levetiracetam

Question 39

Topiramate mech?

Answer 39

antiepilepsy. sodium blocker and GABA agonist

Question 40

Topiramate SE?

Answer 40

weight loss

Question 41

Propofol mech?

Answer 41

antiepilepsy, sodium blocker, GABA agonist

Question 42

Valproate mech?

Answer 42

antiepilepsy sodium blocker, GABA agonist, T current suppressor

Question 43

Toxicity of Valproate?

Answer 43

metabolic bone disease, weight gain

Question 44

Zoisamide mech?

Answer 44

Antiepilepsy, sodium blocker, T current suppressor SE weight loss

Question 45

order of pain block?

Answer 45

pain cold warmth touch deep pressure motor

Question 46

COX inhibitors?

Answer 46

NSAIDs

Question 47

COX inhibitors decrease synthesis and release of what?

Answer 47

prostaglandin

Question 48

NSAIDs work in central or periphery?

Answer 48

periphery

Question 49

Advantages of NSAIDs?

Answer 49

no ceiling effect, decreases inflammation

Question 50

Acetaminophin and NSAIDs difference?

Answer 50

acetaminophen has no effect on inflammation

Question 51

Neuropathic pain treatment?

Answer 51

TCAs, gabapentin, carbamazepine

Question 52

Opiods activate which reprots?

Answer 52

Gi

Question 53

Mu opiod receptors work how?

Answer 53

increases potassum, creating IPSP

Question 54

Opiods work periphery or central?

Answer 54

Central

Question 55

Opiod antagonist?

Answer 55

narcan

Question 56

SE of opiod?

Answer 56

respiratory depression, no ceiling effect

Question 57

Buprenorphine

Answer 57

partial Mu

Question 58

Nalbuphine

Answer 58

moderate kappa

Question 59

Butorphenol

Answer 59

partial Mu, full Kappa

Question 60

Narcan danger?

Answer 60

suddent antagonism can cause sever htn, disrhytmia, acute/fatal PE

Question 61

Benzodiazepine mech?

Answer 61

GABA receptor increases chloride channel opening, hyperpolarizes

Question 62

Benzodiazepine and pain?

Answer 62

NEVER

Question 63

Good for post MI?

Answer 63

morphine

Question 64

mu, weak kappa?

Answer 64

morphine

Question 65

chest rigid after rapid IV admin

Answer 65

fentanyl

Question 66

NMDA antagonist lowers tolerance

Answer 66

Methadone

Question 67

Methadone disadvantage?

Answer 67

accumulation

Question 68

Meperidine advantages?

Answer 68

good for chills, decreases biliary spasms

Question 69

Meperidine disadvantages?

Answer 69

accumulation, long onset

Question 70

Tramadol receptor?

Answer 70

Mu

Question 71

Tramadol mech?

Answer 71

inhibits serotonin and NE reuptake

Question 72

Tramadol SE?

Answer 72

seizures

Question 73

More lipid soluble?

Answer 73

more potent, but slower

Question 74

Thiopental use?

Answer 74

adults, short procedures

Question 75

thiopental pathway

Answer 75

blood, brain, lean tissue takes up bulk and loses it, mostly ends up in fat

Question 76

Inhaled anesthetic given to?

Answer 76

children or for maintenence

Question 77

disadvanage of inhaled

Answer 77

small therapeutic window

Question 78

halothane dange

Answer 78

inhaled, halothane hepatitis

Question 79

SE of inhaled anesthetic

Answer 79

CV: decreases arterial pressure, can be good for CAD Respiratory: bronchodilation hyperthermia: abnormal ryandonine receptor, give dantrolene

Question 80

Ex of inhaled anesthetic

Answer 80

NO, Halothane, flurane

Question 81

Propofol delivery

Answer 81

IV in lipid emulsion

Question 82

SE of propofol

Answer 82

potent CV and respiratory depression, pain at IV site

Question 83

Ketamine delivery

Answer 83

IV but mostly IM

Question 84

use of ketamine

Answer 84

spontaneous breathing

Question 85

SE of ketamine

Answer 85

hallucinations

Question 86

Sedatives/Hynoptics example

Answer 86

Benzodiazepine, Opiates, Barbiturates, GHB

Question 87

Serotonergic ex

Answer 87

SSRI, SNRI MDMA LSD

Question 88

Benzodiazepine vs. barbiturates

Answer 88

barbiturates more easily OD | antianxiety

Question 89

Opiod release mechanism

Answer 89

dopamine in mesolimbic system

Question 90

Ephedrine/Amphetamine vs. MDMA?

Answer 90

E/A acts on DOPAMINE but MDMA on SEROTONIN

Question 91

Anticholinesterase OD?

Answer 91

Atropine

Question 92

Cholinergic OD?

Answer 92

Physostigmine or organophosphates

Question 93

Benzodiazepine OD?

Answer 93

Flumazenil

Question 94

How does flmazenil work?

Answer 94

inhibits benzodiazepine at GABA site

Question 95

Opiod OD

Answer 95

Narcan

Question 96

Acetaminophen OD

Answer 96

N-acetylcysteine, which replenishes glutathione

Question 97

How does folate work on MeOH OD?

Answer 97

promotes formic acid-->CO2

Question 98

Cyanide OD process

Answer 98

1. amyl/sodium nitrate, which promotes hemoglobin-->methemoglobin 2. sodium thisulfate accelerates production of thiocyante (less toxic/more quickly excretes)

Question 99

MeOH and EtGly ingestion?

Answer 99

gives fomepizole to inhibit alcohol dehydrogenase

Question 100

Pralidozime

Answer 100

reactives acetylcholinerase inhibited by organophosphates

Question 101

Warfarin OD

Answer 101

Vitamin K

Question 102

Iron OD

Answer 102

Deferozamine/Deferasirox

Question 103

o Phenytoin treats which epilepsy

Answer 103

Tonic clonic and status epilepticus

Question 104

Phenobarbital epilepsy treats

Answer 104

Neonates

Question 105

Ethosuximide treats what kind of epilepsy

Answer 105

Absense

Question 106

Benzodiazepine treats what epilepsy

Answer 106

acute status epilep

Question 107

Valproate treatswhat kind of epilepsy

Answer 107

Absence and tonic clonic

Question 108

Steven johnson syndrome due to

Answer 108

phenytoin, carbamazepine, ethosuximide toxicity

Question 109

Fetal hydratoin syndrome

Answer 109

phenytoin

Question 110

SSRI toxicity treatment?

Answer 110

Crptoheptadine

Question 111

Is mirtazepine a 2D6 metabolizer?

Answer 111

no

Question 112

SSRI vs SNRI SE?

Answer 112

SSRI-diarrhea and insomnia

Question 113

Thiopental SE?

Answer 113

depressant of pump muscles and upper airway muscles...can produce upper airway obstruction and apnea

Question 114

Maintenance of anesthsia

Answer 114

propofol

Question 115

organophosphate OD?

Answer 115

pralidoxime