Pharm Quiz #3

Question 1

(3) Antibiotic Classes that bind to 50s Ribosomal Subunit

Answer 1

1. Macrolides
2. Lincoamides
3. Oxazolidinones

Question 2

(2) Antibiotic Classes that bind to 30s Ribosomal Subunit

Answer 2

1. Tetracyclines

2. Aminoglycosides

Question 3

Antibiotic class that Inhibits Dihydrofolate Reductase in Protozoa.

Answer 3

Pyrimethamines— Pyrimidine

Question 4

Antibiotic Class that Blocks folate production and folate synthesis by “pretending to be PABA”

Answer 4

Sulfonamides

Question 5

Fosfomycin, Nitrofuration, and Phenazopyridine are all examples of ____ Drugs. (3 letters)

Answer 5

UTI drugs

Question 6

This drug binds to cell wall precursors (Lipid II) and makes them too large for incorporation.

Answer 6

Vancomycin

Question 7

MOA of Mupirocin?

Answer 7

Inhibits bacterial Protein synthesis

Question 8

New expensive C. Diff medication?

Answer 8

Bezlotoxumab (-mab) = expensive

Question 9

Old school drug that Increases cell membrane permeability and Neutralizes Endotoxins?

Answer 9

Colistin (Polymyxin E)

Question 10

Antibiotic class that inhibits bacterial synthesis by Inhibiting DNA gyrase and Topoisomerase IV

Answer 10

Fluoroquinolones

Question 11

Antibiotic Duo that Inhibit early and late protein synthesis?

Answer 11

Quinupristin/Dalfopristin (Synercid)

Q = late D = early (in ribosome)

Question 12

Name 2 Oxazolidinones

Answer 12

1. Linezolid

2. Tedizolid

Question 13

Name 4 Macrolides

Answer 13

1. Erythromycin
2. Clarithromycin
3. Azithromycin
4. Fidaxomicin

Question 14

Name the only Lincoamide

Answer 14

Clindamycin

Question 15

Name 5 Aminoglycosides

Answer 15

1. Amikacin
2. Gentamicin
3. Neomycin
4. Streptomycin
5. Tobramycin

Question 16

What drug could you use to decrease buring, dysuria, and frequency with urination?

Answer 16

Phenazopyridine (Pyridium)

-Urinary tract Analgesic

Question 17

Antibiotic class that interferes with Cross-Linking of peptidoglycan in bacterial cell walls.

Answer 17

Lipoglycopeptides

Question 18

Name 2 Lipoglycopeptides

Answer 18

1. Oritavancin

2. Dalbavancin

Question 19

Name 2 Oxazolidinones

Answer 19

1. Linezolid

2. Tedizolid

Question 20

What kind of molecules indicate that Baceria are present in Urine?

Answer 20

Nitrates

Question 21

Name 4 Fluoroquinolones

Answer 21

1. Ciprofloxacin
2. Levofloxacin
3. Moxifloxacin
4. Gatifloxacin

Question 22

Name 5 Tetracyclines

Answer 22

1. Tetracycline
2. Doxycycline
3. Minocycline
4. Demeclocycline
5. Tigecycline

Question 23

What does Steven-Johnson Syndrome (SJS) affect?

Answer 23

Skin and Mucous Membranes (can be fatal)

—-Erythromycins, PCNS, barbituates, Sulfamides

Question 24

What does TENS stand for?

Answer 24

Toxic Epidermal Necrolysis

Question 25

Name 4 Sulfonamides

Answer 25

1. Silver Sulfadiazine 2. Sulfacetamides 3. Sulfasalazine 4. Sulfamethoxazole/Trimethoprim (trimethoprim = dihydrofolate reductase inhibitor)

Question 26

What drugs cover MRSA?

Answer 26

1. Vancomycin 2. Oxazolidinones (Linezolid and Tedizolid) 3. Lipoglycopeptides (Oritavancin and Dalbavancin) 4. Quinupristin/Dalfopristin 5. Clindamycin 6. Sulfamethoxanzole/trimethoprim (skin MRSA) 7. Moxifloxacin 8. Mupirocin

Question 27

Drugs to worry about Ototoxicity

Answer 27

1. Aminoglycosides | 2. Vancomycin

Question 28

Drug associated with Red Man Syndrome?

Answer 28

Vancomycin

Question 29

2 main ADRs associated to Aminoglycosides?

Answer 29

1. Ototoxicity | 2. Nephrotoxicity

Question 30

Drugs that affect Pseudomonas?

Answer 30

1. Ciprofloxacin 2. Nitrofurantoin 3. Levofloxacin 4. Colistin (last resort)

Question 31

2 Big P450 interacting drugs

Answer 31

Erythromycin | Quinupristin/Dalfopristin

Question 32

2 Big Respiratory antibiotics (bronchitis and pneumonia)

Answer 32

1. Levofloxacin | 2. Moxifloxacin

Question 33

2 Classes of drugs that prolong QT.

Answer 33

1. Macrolides | 2. Fluoroquinolones

Question 34

Diarrhea in a pill?

Answer 34

Clindamycin (good for malaria and anaerobes)

Question 35

(3) Drug Classes requiring renal adjustment?

Answer 35

1. Tetracyclines (for lyme disease) 2. Fluoroquinolones 3. Vancomycin