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Flashcards in pharm test 2 ADR Deck (26)
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1
Q

Insulin

A

hypoglycemia:(tremors, palpitations, sweating, excessive hunger, HA, mood changes, irritability, uncousness, sz)secretion of glucagon and epinephrine are blunted, weight gain, lipohypertrophy, hypokalemia, allergic reaction at injection site, insulin antibodies

2
Q

Pramlintide(symlin)

A

hypoglycemia(black box warning)*** nausea.

3
Q

SulfonylureasRepaglinide

A

hypoglycemia,weight gain, muscular weakness, dizziness, confusion, skin rash, photosensitivity, blood dyscrasias, cholestatic jaundice

4
Q

Repaglinide

A

hypoglycemia, weight gain

5
Q

Metformin

A

diarrhea, abd bloating, nausea, ***lactic acidosiswith greater potential with **renal failure pts

6
Q

Rosiglitazone(Avandia) and pioglitazone(actos)

A

fluid retention and peripheral edema, weight gain, **new onset heart failure. ***Black box warning regarding CHF and MI

7
Q

Acarbose(precise) and miglitol (glyset)

A

NOT well tolerated, loose stools, flatulence, abd cramping

8
Q

Sitagliptin(Januvia) and Saxagliptin (onglyza)

A

well tolerated

9
Q

Colesevelam (WelChol)

A

constipation/nausea, indigestion, increase TG

10
Q

Exenatide (Byetta)

A

N/V/D, modest weight loss, hypoglycemia, anti-exenatide antibodies

11
Q

Levothyroxine(synthroid, levothroid, levoxyl, unithroid)

A

arrhythmias, tachycardia, angina pain, cramps, HA, restlessness, sweating, weight loss, osteoporosis

12
Q

Propylthiouracil(PTU) and Methimazole(Tapazole)(MMI)

A

cause hypothyroidism, arganulocytosis, hypatotoxicity, vasculitis, rash, arthralgia, myalgia, cholestatic jaundice, lymphadenopathy, drug fever, psychosis, alopecia

13
Q

KI

A

hypersensitivity rxn, HA, lacrimation, conjunctivitis, laryngitis, thyrotoxicosis, drug fever, acneform rash, metallic taste in mouth

14
Q

Metyrapone(metopirone)

A

N/V, HTN, alopecia, hirsutism

15
Q

Aminoglutethimide(cytadren)

A

N/V, sedation, hypothyroidism

16
Q

Ketoconazole(Nizoral)

A

hepatotoxicity, gynecomastia, nausea

17
Q

Mitotane(lysodren)

A

N/V, lethargy, somnolence, hypercholesterolemia

18
Q

Spironolactone

A

hyperkalemia, gynecomastia

19
Q

Octreotide

A

N, D, hyperglycemia, arrhythmias, hypothyroidism, cholelithiasis

20
Q

Bromocriptine and Ergot alkaloid

A

N/V, HA, dizziness, hypotension

21
Q

Pegvisomant

A

N,D, AST & ALT elevations

22
Q

Genotropin

A

slipped capital femoral epiphysis, idiopathic intracranial hypertension

23
Q

Mescasermin

A

***Hypoglycemia, dizziness, arthralgias

24
Q

Bromocriptine

A

N/V, HA, dizziness, hypotension

25
Q

Cabergoline

A

N/V, HA, dizziness, hypotension, reports of valvular heart disease when high dose used

26
Q

Glucocorticoids

A

Withdrawal of therapy= flare up of underlying disease, acute adrenal insufficiencyGeneral: wt gain, increase appetiteCNS: mood changes- euphoria leads to depression, psychosisOpthamology: cataracts later in life, **Glaucoma due to increased intraocular pressureCV: HTN, dyslipidemiaHeme: immunosuppression, infection, impaired wound healingGI: Peptic ulcer disease, suppression of response to H. pyloriBone: osteoporosis (prevent w/ bisphos + calcium and Vit D), Aseptic necrosis of hip, growth suppression, myopathyEndocrine: cushing’s syndrome, adrenal suppression, glucose intolerance/ DMmineral corticoid ADRSkin: Acne, easy bruising, thin skin, striae