Pharma 1

Question 1

list 4 factors that increase the risk of developing ulcers

Answer 1

smoking, alcohol, vagal stimmulation, Hpylori

Question 2

there are two receptors on the parietal cell that promote its HCl secretion

Answer 2

histamine receptor, ach receptor

Question 3

gastrin secreted by the G cells acts on

Answer 3

ECL cell

Question 4

the ECL cell acts on which cell, and is stimulated by

Answer 4

its stimulated by gasrtrin, and Ach, it secretes histamine that acts on pariteal cells

Question 5

name the drugs used to reduce gastric secretion

Answer 5

antihistamines (h2 receptor antagonists), ppis, prostaglandins, anticholinergics

Question 6

name the drugs used to reuce irritationo n mucosal lining

Answer 6

antacids

Question 7

name the drugs that coat/ form a barrier on the mucosal lining

Answer 7

sucralfate

Question 8

name the drugs that work against Hpylori

Answer 8

antibiotics bitch :D

Question 9

h2 receptor antagonists work on which cell, whats the parent drug, and name the most common drug

Answer 9

pariteal cells, cimetidine = parent drug, ranitidine = most commonly prescribed

Question 10

whats the most problematic side effect of cimetidine

Answer 10

gynaeomastia in males, menstural irregularities in females

Question 11

why does cimetidine cause gynecomastia and mentstural disturbances

Answer 11

because it binds to androgen receptors

Question 12

what is the first line drug for severe ulcers

Answer 12

ppis

Question 13

t or F, ppis reversibly block h-k pumps of g cells

Answer 13

irreversible, parietal cells

Question 14

which drug supresses acids stonger and for longer time, ppis or H2 antagonists

Answer 14

ppi winnnns

Question 15

state examples for h2 receptor antagonists, parent drug and what is used more often

Answer 15

omeprazole = parent drug, esmeprazole used more often because it has less side effects

Question 16

t or f, ppis are alkaline in nature

Answer 16

TRUE

Question 17

impotence, hypersensitivity reactions are SE of

Answer 17

ppis

Question 18

do antacids reach systemic circulation

Answer 18

noppe

Question 19

if calcium carbonate antacis with milk, whats the condition that ppts

Answer 19

milk alkali syndrome –> renal failure

Question 20

other than milk alkali syndrome, whats another side effect of calcium containing anacids

Answer 20

kidney stones

Question 21

SE of sucralfate

Answer 21

constipation

Question 22

SE of bismuth chelate

Answer 22

blacken teeth and stool

Question 23

T or F, bismuth and sucralfate must be given on an empty stomach

Answer 23

true, the drug that needs to be eaten with food is prostaglandins because they cause diarrhea

Question 24

which drug shouldnÕt be used during pregnancy due to abortifacient activity

Answer 24

prostaglandins

Question 25

prostaglandin receptor mediates

Answer 25

bicarb production and mucus secretion

Question 26

name a prostaglandin E analogue

Answer 26

misoprostol

Question 27

whats the first line therapy for h pylori ulcers

Answer 27

omerprazole, amoxixilllin, clarithromyciin

Question 28

prokinetic agents that are used to treat GERD

Answer 28

metoclopramide huydrogloride

Question 29

islet cell tumor of the pancreas or duodenum

Answer 29

Zollinger ellison syndomre

Question 30

t or f, pts with zollinger ellison syndrome present with diarrhea

Answer 30

TRUE

Question 31

management of ZE syndrome

Answer 31

Ppis

Question 32

atropine inhibits

Answer 32

M3r

Question 33

misoprostol activates

Answer 33

EP23R