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LEVEL II > PHARMA 6 > Flashcards

PHARMA 6 Flashcards

1
Q

Which of the following drug characteristics would best ensure percutaneous absorption?

A. Molecular mass > 500 Da
B. Low partition coefficient
C. Adequate solubility in both water and oil
D. Capacity to pass through the stratum corneum

A

D. Capacity to pass through the stratum corneum

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2
Q

Which drug is indicated for neurogenic pruritus?

A. Cetirizine
B. Gabapentin
C. Naloxone
D. Thalidomide

A

B. Gabapentin

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3
Q

Prolonged use of this topical drug has the propensity to cause adrenal insufficiency when stopped abruptly

A. Betamethasone dipropionate
B. Permethrin
C. Isoretinoin
D. Silver sulfadiazine

A

A. Betamethasone dipropionate

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4
Q

Which of the following components of sunscreens acts as a “physical blocker”?

A. Titanium dioxide
B. Salicylate
C. Camphor
D. Aminobenzoate

A

A. Titanium dioxide

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5
Q

A 19-year-old male went to a dermatologic clinic due to multiple pustules and papules located on the cheeks and forehead. Closer examination also revealed presence of white and black comedones. Patient attributed the condition to stress from his upcoming final exams. What is the cornerstone of therapy for this patient?

A. Removal of comedones
B. Benzoyl peroxide
C. Adapalene
D. Clindamycin solution

A

C. Adapalene

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6
Q

Which vehicle for topically applied drugs spreads and removes easily and can be applied in many locations of the body?

A. Gel
B. Lotion
C. Ointment
D. Cream

A

D. Cream

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7
Q

A 28-year-old male deprived of liberty consulted in the infirmary clinic due to severe generalized pruritus particularly on the hands, feet and groin. He claimed that his cell mates also manifested the same condition. Physical examination showed presence of “burrows” in interdigital webs and wrists and erythema and excoriations on the groin and feet. If an arthropod infestation is highly considered in this patient, which drug is indicated?

A. Lindane
B. Mupirocin
C. Tretinoin
D. Salicylic acid

A

A. Lindane

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8
Q

Prolonged use of which of these topical glucocorticoids will most likely cause skin atrophy?

A. Triamcinolone acetonide cream 0.5%
B. Diflorasone diacetate cream 0.05%
C. Diflorasone diacetate cream 0.05%
D. Clobetasol propionate cream 0.05%

A

D. Clobetasol propionate cream 0.05%

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9
Q

Which antibiotic for cutaneous bacterial infections is relatively safest on the premise that it does not affect normal skin flora?

A. Gentamicin
B. Neomycin
C. Mupirocin
D. Bacitracin

A

C. Mupirocin

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10
Q

Photochemotherapy using methoxsalen is indicated in patients with

A. 2nd degree sunburn
B. hyperkeratotic disorders
C. psoriasis
D. acne vulgaris

A

C. psoriasis

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11
Q

Which of the following methods in photochemotherapy is indicated in psoriasis?

A. PUVA
B. Photophoresis
C. Photodynamic therapy
D. Any of these

A

A. PUVA

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12
Q

Which of the following vehicles for topical drugs has the least amount of water?

A. Ointment
B. Gel
C. Lotion
D. Cream

A

A. Ointment

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13
Q

Which of the following retinoid targets the retinoid X receptor?

A. Tretinoin
B. Tazarotene
C. Alitretinoin
D. Adapalene

A

C. Alitretinoin

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14
Q

Which of the following drug characteristics would best ensure percutaneous absorption?

A. Molecular mass less than 500 Da
B. High partition coefficient
C. Adequate solubility in both water and oil
D. Capacity to pass through the stratum corneum

A

D. Capacity to pass through the stratum corneum

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15
Q

Which of the following components of sunscreens acts as a “chemical blocker” for UVA?

A. Camphor
B. Zinc oxide
C. Aminobenzoate
D. Titanium dioxide

A

A. Camphor

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16
Q

Which of these topical antibiotics has specific activity against aerobic gram-negative bacilli?

A. Polymyxin B
B. Neomycin
C. Bacitracin
D. Mupirocin

A

A. Polymyxin B

17
Q

Which of the following glucocorticoids is most potent?

A. Flucinolone acetonide, cream 0.2%
B. Betamethasone dipropionate cream 0.05%
C. Clobetasol propionate cream 0.05%
D. Betamethasone valerate cream 0.1%

A

C. Clobetasol propionate cream 0.05%

18
Q

Which of the following drugs is used for hyperkeratotic disorders?

A. Diphenhydramine
B. Calamine
C. Salicylic acid
D. Lindane

A

C. Salicylic acid

19
Q

Which of the following drug characteristics best ensure percutaneous absorption?

A. High partition coefficient
B. Molecular mass of <500 Da
C. Adequate solubility in both water and oil
D. Capacity to pass through the stratum corneum

A

A. High partition coefficient

20
Q

On topical drugs, oil preparation is more advantageous than cream preparation because:

A. Spreads easily
B. requires a humectant
C. increases skin moisture
D. greaseless and non-staining

A

C. increases skin moisture

21
Q

Which of the following is most potent?

A. Betamethasone valerate cream 0.1%
B. Betamethasone valerate ointment 0.1%
C. Betamethasone diproprionate cream 0.05%
D. Betamethasone diproprionate ointment 0.05%

A

D. Betamethasone diproprionate ointment 0.05%

22
Q

Which of these topical glucocorticoids will most likely cause skin atrophy?

A. Diflorasone Diacetate cream 0.05%
B. Clobetazol Propionate cream 0.05%
C. Fluocinolone Acetonide cream 0.2%
D. Triamcinolone Acetonide cream 0.5%

A

B. Clobetazol Propionate cream 0.05%

23
Q

Which of the ff. is a component of sunscreen and acts as a physical barrier?

A. Camphor
B. Salicylate
C. Zinc Oxide

A

C. Zinc Oxide

24
Q

Which of the following method of photochemotherapy is associated with psoriasis

A. PUVA
B. Photophoresis
C. Photodynamic Therapy
D. All of the above mentioned

A

A. PUVA

25
Q

Used to treat hyperkeratotic infection

A. Permethrine
B. Propylene Glycol
C. Urea
D. Salicylic acid

A

D. Salicylic acid

26
Q

Which of the ff vehicle extremely maximizes drug efficacy when used on the skin?

A. Lotion
B. Powder
C. Cream
D. Gel

A

D. Gel

27
Q

Which of the following vehicles allow metered release of the drug, thus producing less of the skin irritation?

A. Oil-in-water creams
B. Water-in-oil creams
C. Microparticles
D. Liposomes

A

C. Microparticles

28
Q

Which of the following topical corticosteroids are of value in facial application?

A. Betametasone diproprionate cream 0.05%
B. Desoximethasone ointment 0.25%
C. Triaminoclone acetonide ointment 0.1%
D. Hyrocortisone cream 0.5%

A

D. Hyrocortisone cream 0.5%

29
Q

Which of the following is a 3rd generation retinoid?

A. Tretinion
B. Isotretinoin
C. Etretinate
D. Tazarotene

A

D. Tazarotene

30
Q

Which of the following is effective for basal cell carcinoma?

A. Isotretinoin
B. Alitretinoin
C. Bexarotene
D. Adapalene

A

A. Isotretinoin

31
Q

A 10 y/o girl was brought by her mother for consultation because of head lice.
Lindane was prescribed. Which of the following should you instruct to your
patient?

A. Apply the undiluted cream to the hair for 10 mins, rinse with warm water
B. Apply the lotion to the dry hair for 10 mins, rinse with water
C. Apply the shampoo to the dry hair for 4 mins, rinse with water
D. Apply the lotion to the dry hair for 4-6 hours, rinse with water

A

D. Apply the lotion to the dry hair for 4-6 hours, rinse with water

32
Q

This drug is effective for treatment of impetigo caused by Staphyloccus aureus and Gram A beta-hemolytic streptococci

A. Bacitracin
B. Muciprocin
C. Gramicidin
D. Polymyxin B

A

B. Muciprocin

LEVEL II (16 decks)

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