pharma

Question 1

Leukotrienes involved in bronchoconstriction

Answer 1

LTC4 LTD4

Question 2

Person w/allergy to sulfas cannot take this drug

Answer 2

celecoxib (is a sulfa)

Question 3

Glucocorticoid therapy will increase/decrease WBC ?

Answer 3

will increase. (neutrophilic leukocytosis) Impaired migration to sites of inflammation so you will see more in plasma

Question 4

Calcineurin inhibitors are metabolized by

Answer 4

cyt p450 system - many interaction

Question 5

DOC to treat HTN 2ry to cyclosporine/tacrolimus toxicity?

Answer 5

Diltiazem bc inhibits p450 so you treat the HTN and also decrease the Dose of cyclosporine/tacrolimus

Question 6

Penicillin allergy is common and can present as ?????

Answer 6

a rash, anaphylaxis, hemolytic anemia, and acute interstitial nephritis (AIN). AIN classically presents as elevated creatinine with urinary WBC casts and eosinophilia.

Question 7

Adverse effects of imipinem:

Answer 7

gastrointestinal distress, thrombophlebitis, skin rashes, and seizures.

Question 8

mycophenolate and ribavirin mechanism is

Answer 8

inhibit IMP dehydrogenase (X purine synthesis)

Question 9

hydroxyurea mechanism of action is

Answer 9

inhibits Ribonucleotide reductase (X pyrimidine synthesis, UDP to dUDP step)

Question 10

6 MP & prodrug azathioprine inhibit

Answer 10

de novo purine synthesis (PRPP to IMP)

Question 11

5FU and its prodrug capecitabine inhibit

Answer 11

form 5F-dUMP which inhibits thymidylate synthase (decrease dTMP) @pyrimidine synthesis

Question 12

MTX, TMP and pyrimethamine inhibit

Answer 12

dihydrofolate reductase (decreases dTMP so does not form DNA)

Question 13

LEflunomide inhibits

Answer 13

Dihydroorotate dehydrogenase

Question 14

which drug interfere with both purine and pyrimidine synthesis

Answer 14

hydroxyurea (S phase specific)

Question 15

which drugs interfere w purine synthesis

Answer 15

6 MP and prodrug azathioprine and mycophenolate and ribavirin

Question 16

drugs that interfere w pyrimidine synthesis

Answer 16

LEFLUNOMIDE
MTX, TMP, PYRIMETHAMINE
5 FU

Question 17

name the 2 calcineurin inhibitors

Answer 17

cyclosporine and tacrolimus (FK506)

Question 18

the 2 calcineurin inhibitors are highly

Answer 18

nephrotoxic

Question 19

name cyclosporine toxicities

Answer 19

nephrotoxicity, htn, hyperlipidemia, neurotox, gingival hyperplasia, hirsutism.

Question 20

cyclosporin prevents transcription of

Answer 20

blocks T cell activation by preventing IL2 transcription

Question 21

cyclosporine binds

Answer 21

cyclophilin

Question 22

tacrolimus binds

Answer 22

FK binding protein

Question 23

Sirolimus (rapamycin) binds

and inhibits

Answer 23

FKBP . mTOR

Question 24

sirolimus blocks

Answer 24

T cell activation and B cell diferentiation by preventing response to IL2

Question 25

blocks IL2, tox is edema, htn, tremor

Answer 25

basiliximab

Question 26

3 examples of weak acids

Answer 26

phenobarbital, Mtx and aspirin are

Question 27

2 weak bases are

Answer 27

tcas, amphetamines, quinidine, phencyclidine PCP

Question 28

Nicotinic Ach receptors are

Answer 28

ligand-gated Na/K channels. (Nm and Nn)

Question 29

Muscarinic Ach receptors are

Answer 29

G protein coupled Receptors.

Question 30

Name AchEst i to treat Alzheimer

Answer 30

Donepezil, Rivastigmine, Galantamine, (Dona Riva dances at the GALA) problem is No Ach

Question 31

why di you use Benztropine to treat Parkinson or acute dystonia

Answer 31

To decrease Ach (is a muscarinic antagonist)

Question 32

neostigmine _ crosses BBB and is a _amine

Answer 32

do not, quaternaty amine

Question 33

Physostigmine _ crosses BBB and is a _ amine

Answer 33

phreely enters CNS and is a Tertiary amine