Pharma Antibiotics

Question 1

CHON synthesis inhibitor at 50s subunit used in meningitis because it crosses BBB

Answer 1

Chloramphenicol

Question 2

Only macrolide that doesn’t inhibit CYP450

Answer 2

Azithromycin

Also has highest Vd and slowest elimination

Question 3

Bacteriostatic drug that binds to 50s subunit that causes serotonin syndrome as an adverse effect

Answer 3

Linezolid

Question 4

Most important drug in TB; inbihit mycolic acid synthesis

Answer 4

Isoniazid

Question 5

Bactericidal antibiotics

Answer 5

Vancomycin
Fluoroquinolones
Penicillins
Aminoglycosides
Metronidazole

Question 6

Most vestibulotoxic and nephrotoxic aminoglycosides

Answer 6

Tobramycin

Gentamycin

Question 7

Aminoglycoside for drug redistant gonorrhea

Answer 7

Spectinomycin

Question 8

Antimycobacterial that inhibit arabinosyl transferase

Answer 8

Ethambutol

Question 9

3rd gen cephalosporins with disulfiram reaction

Answer 9

Cefoperazone

Question 10

Most ototoxic aminoglycoside

Answer 10

Kanamycin

Amikacin

Question 11

Ototoxicity in aminoglycosides is aggravated when used with?

Answer 11

Loop diuretics

Cisplatin

Question 12

Bacteriostatic inhibitors of folic acid synthesis by competitively inhibiting dihydropteroate synthase

Answer 12

Sulfonamides

Question 13

Cardiotoxic 3rd gen fluoroquinolone

Answer 13

Grepafloxacin

Question 14

Action of rifampicin

Answer 14

Inhibit DNA dependent RNA polymerase

Question 15

Fluoroquinolones block bacterial DNA synthesis by inhibiting ____________ in gram negative organisms and _____________ in gram positive organisms

Answer 15

Topoisomerase II (DNA gyrase)

Topoisomerase IV

Question 16

Antimetabolite class of drug that blocks D-Ala incorporation into the pentapeptide chain of Peptidoglycan

Answer 16

Cycloserine

2nd line drug for MDR TB

Question 17

Aminoglycosides with the narrowest therapeutuc window

Answer 17

Amikacin

Question 18

Penicillin class for staph infection that is resistant to B-lactamase inhibition

Answer 18

Methicillin
Nafcillin
Oxacillin
Cloxacillin

Question 19

Most hepatotoxic anti-TB drug? cidal or static?

Answer 19

Pyrazinamide

Bacteriostatic but can be bactericidal on actively dividing mycobacteria

Question 20

Drug MOA is inhibition by binding to thr D-Ala-D-Ala terminus of nascent peptidoglycan

Answer 20

Vancomycin

Question 21

Used in sulfone resistant leprosy? MOA?

Answer 21

Clofazimine

Binds to guanine bases in bacterial DNA

Question 22

MOA of Flucytosine

Answer 22

Inhibit thimidylate synthase

Question 23

Antifungal that inhibit B-glucan synthase decreasing fungal cell wall synthesis

Answer 23

Caspofungin
Anidulafungin
Micafungin

Question 24

MOA of Terbinafine

Answer 24

Interfere with ergosterol synthesis by inhibiting fungal squalene oxidase

Question 25

Antiviral that inhibit neuraminidase that is causes bronchospasm in asthmatics

Answer 25

Zanamivir

Question 26

DOC for African sleeping sickness

Answer 26

Melarsoprol

Question 27

Antiviral that doesn't require thymidine kinase to become active again strains of HSV

Answer 27

Cifodovir Foscarnet

Question 28

Electrolyte abnormality in patients taking Foscarnet

Answer 28

Hypocalcemia

Question 29

Nucleoside reverse transcriptase inhibitor that causes bone marrow suppresion as an adverse effect

Answer 29

Zidovudine

Question 30

Non nucleoside reverse transcriptase inhibitor that is both a inducer and inhibitor of CYP 450

Answer 30

Etravirine

Question 31

Inhibit HBV DNA polymerase

Answer 31

``` Lamivudine Adefovir Dipovoxil Entecavir Telbivudine Tenofovir ```

Question 32

Antiviral that blocks RNA dependent RNA polymerase

Answer 32

Ribavirin

Question 33

Antimalarial DOC pregnant patients

Answer 33

Quinine

Question 34

DOC for Trichinosis

Answer 34

Thiabendazole

Question 35

Treatment and prophylaxis for chloroquine resistant P. Falciparum

Answer 35

Atovaquone-Proguanil Atovaquone- disrupt mitchodrial electron transport. Blood and tissue schizonticide Proguanil- inhibit folate synthesis. Sporonticide

Question 36

Antiviral that inhibit neuraminidase

Answer 36

Oseltamivir | Zanamivir

Question 37

DOC for uncomplicated falciparum malaria in Philippines

Answer 37

Artemether-Lumentabtine

Question 38

Antiprotozoal DOC for asymptomatic cyst carried of E. histolytica

Answer 38

Diloxanide Furoate

Question 39

Ivermectin DOC for

Answer 39

Strongyloidiasis

Question 40

Antiprotozoal used only for situation where metronidazole cant be used

Answer 40

Emetine

Question 41

Albendazole is the DOC for

Answer 41

Hydatid disease

Question 42

DOC for severe intestinal and extraintestinal amoebiasis

Answer 42

Metronidazole

Question 43

DOC for hookworm and roundworm infections

Answer 43

Pyrantel pamoate Depolarization induced paralysis Enterobius

Question 44

DOC for prophylaxis and treatment of toxoplasmosis. MOA?

Answer 44

Pyrimethamine-sulfadiazine Sequential blockade lf dihydropteroate synthase(sulfadiazine) and dihydrofolate reductase(pyrimethamine)

Question 45

DOC of Cryptosporidiosis

Answer 45

Nitazoxanide

Question 46

DOC for prophylaxis and treatment of Pneumocystosis

Answer 46

Co-trimoxazole

Question 47

Antiprotozoal used in the hemolymphatic stage of African sleeping sickness

Answer 47

Suramin

Question 48

DOC of Chagas disease

Answer 48

Nifurtimox

Question 49

DOC for trematodes

Answer 49

Praziquantel

Question 50

DOC of Advance West African sleeping sickness

Answer 50

Eflornithine Suicide inhibitor of ornithine decarboxylase Crosses BBB

Question 51

DOC of Leishmaniasis? Except in what country?

Answer 51

Sodium stibogluconate India

Question 52

2nd gen cephalosporins with disulfiram reaction

Answer 52

Cefamandole | Cefotetan

Question 53

DOC for Filariasis

Answer 53

Diethylcarbamazine

Question 54

DOC for whipworm infections

Answer 54

Mebendazole Contraindicated in pregnancy Trichuris

Question 55

Only antibiotic with nasal spray route of administration

Answer 55

Pentamidine

Question 56

Antihelminthic that kills scolices and cestode segments but has no effect on ova

Answer 56

Niclosamide aka IRIS JON

Question 57

If you were a cactus why?

Answer 57

If not why not? Breaktime! ?