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Flashcards in Pharma Antibiotics Deck (57):
1

CHON synthesis inhibitor at 50s subunit used in meningitis because it crosses BBB

Chloramphenicol

2

Only macrolide that doesn't inhibit CYP450

Azithromycin

Also has highest Vd and slowest elimination

3

Bacteriostatic drug that binds to 50s subunit that causes serotonin syndrome as an adverse effect

Linezolid

4

Most important drug in TB; inbihit mycolic acid synthesis

Isoniazid

5

Bactericidal antibiotics

Vancomycin
Fluoroquinolones
Penicillins
Aminoglycosides
Metronidazole

6

Most vestibulotoxic and nephrotoxic aminoglycosides

Tobramycin
Gentamycin

7

Aminoglycoside for drug redistant gonorrhea

Spectinomycin

8

Antimycobacterial that inhibit arabinosyl transferase

Ethambutol

9

3rd gen cephalosporins with disulfiram reaction

Cefoperazone

10

Most ototoxic aminoglycoside

Kanamycin
Amikacin

11

Ototoxicity in aminoglycosides is aggravated when used with?

Loop diuretics
Cisplatin

12

Bacteriostatic inhibitors of folic acid synthesis by competitively inhibiting dihydropteroate synthase

Sulfonamides

13

Cardiotoxic 3rd gen fluoroquinolone

Grepafloxacin

14

Action of rifampicin

Inhibit DNA dependent RNA polymerase

15

Fluoroquinolones block bacterial DNA synthesis by inhibiting ____________ in gram negative organisms and _____________ in gram positive organisms

Topoisomerase II (DNA gyrase)

Topoisomerase IV

16

Antimetabolite class of drug that blocks D-Ala incorporation into the pentapeptide chain of Peptidoglycan

Cycloserine

2nd line drug for MDR TB

17

Aminoglycosides with the narrowest therapeutuc window

Amikacin

18

Penicillin class for staph infection that is resistant to B-lactamase inhibition

Methicillin
Nafcillin
Oxacillin
Cloxacillin

19

Most hepatotoxic anti-TB drug? cidal or static?

Pyrazinamide

Bacteriostatic but can be bactericidal on actively dividing mycobacteria

20

Drug MOA is inhibition by binding to thr D-Ala-D-Ala terminus of nascent peptidoglycan

Vancomycin

21

Used in sulfone resistant leprosy? MOA?

Clofazimine

Binds to guanine bases in bacterial DNA

22

MOA of Flucytosine

Inhibit thimidylate synthase

23

Antifungal that inhibit B-glucan synthase decreasing fungal cell wall synthesis

Caspofungin
Anidulafungin
Micafungin

24

MOA of Terbinafine

Interfere with ergosterol synthesis by inhibiting fungal squalene oxidase

25

Antiviral that inhibit neuraminidase that is causes bronchospasm in asthmatics

Zanamivir

26

DOC for African sleeping sickness

Melarsoprol

27

Antiviral that doesn't require thymidine kinase to become active again strains of HSV

Cifodovir

Foscarnet

28

Electrolyte abnormality in patients taking Foscarnet

Hypocalcemia

29

Nucleoside reverse transcriptase inhibitor that causes bone marrow suppresion as an adverse effect

Zidovudine

30

Non nucleoside reverse transcriptase inhibitor that is both a inducer and inhibitor of CYP 450

Etravirine

31

Inhibit HBV DNA polymerase

Lamivudine
Adefovir Dipovoxil
Entecavir
Telbivudine
Tenofovir

32

Antiviral that blocks RNA dependent RNA polymerase

Ribavirin

33

Antimalarial DOC pregnant patients

Quinine

34

DOC for Trichinosis

Thiabendazole

35

Treatment and prophylaxis for chloroquine resistant P. Falciparum

Atovaquone-Proguanil

Atovaquone- disrupt mitchodrial electron transport. Blood and tissue schizonticide

Proguanil- inhibit folate synthesis. Sporonticide

36

Antiviral that inhibit neuraminidase

Oseltamivir
Zanamivir

37

DOC for uncomplicated falciparum malaria in Philippines

Artemether-Lumentabtine

38

Antiprotozoal DOC for asymptomatic cyst carried of E. histolytica

Diloxanide Furoate

39

Ivermectin DOC for

Strongyloidiasis

40

Antiprotozoal used only for situation where metronidazole cant be used

Emetine

41

Albendazole is the DOC for

Hydatid disease

42

DOC for severe intestinal and extraintestinal amoebiasis

Metronidazole

43

DOC for hookworm and roundworm infections

Pyrantel pamoate

Depolarization induced paralysis

Enterobius

44

DOC for prophylaxis and treatment of toxoplasmosis. MOA?

Pyrimethamine-sulfadiazine

Sequential blockade lf dihydropteroate synthase(sulfadiazine) and dihydrofolate reductase(pyrimethamine)

45

DOC of Cryptosporidiosis

Nitazoxanide

46

DOC for prophylaxis and treatment of Pneumocystosis

Co-trimoxazole

47

Antiprotozoal used in the hemolymphatic stage of African sleeping sickness

Suramin

48

DOC of Chagas disease

Nifurtimox

49

DOC for trematodes

Praziquantel

50

DOC of Advance West African sleeping sickness

Eflornithine

Suicide inhibitor of ornithine decarboxylase

Crosses BBB

51

DOC of Leishmaniasis? Except in what country?

Sodium stibogluconate

India

52

2nd gen cephalosporins with disulfiram reaction

Cefamandole
Cefotetan

53

DOC for Filariasis

Diethylcarbamazine

54

DOC for whipworm infections

Mebendazole

Contraindicated in pregnancy

Trichuris

55

Only antibiotic with nasal spray route of administration

Pentamidine

56

Antihelminthic that kills scolices and cestode segments but has no effect on ova

Niclosamide

aka IRIS JON

57

If you were a cactus why?

If not why not?

Breaktime! ?