Pharma MT1 Flashcards
(237 cards)
Which of the following can occur at therapeutic dosage levels in healthy patients? Allergic reactions Teratogenic effects Idiosyncratic reactions All of the above can occur
All of the above can occur
MRL is an acronym for: Minimum relevant level Maximum residue limit Medicine residue level Medicine registry list
Maximum residue limit
Usually for mixing these types of real drugs into the medicated feedstuff, commercial feed compounders need to have a prescription for Medicated Feedstuff (Veterinary Written Direction). POM-V Pharmacy Medicines (P) Prescription only medicines (POM) AVM-GSL
POM-V
Quantal dose response curves are:
Obtainable from the study of intact subjects but not from isolated tissues
Used for determining the maximal efficacy of a drug
Used in determining the therapeutic index of a drug
Invalid in the presence of inhibitors of the drug studied
Used in determining the therapeutic index of a drug
The adhesive of the granules can be:
Distilled water
Which drugs have to be kept in a locked receptacle with the key in possession of a veterinarian?
Schedule 2 and 3 drugs
What is the first pass effect?
Liver decomposes the orally applied drug
In which book can the indications, effects, and side effects of a given drug be found?
British Veterinary Formulary
The capacity of a drug to cause a particular action?
Specificity
A drug that mediates the reversal of histamine bronchoconstricition (mediated at the histamine receptors) by acting at adrenoceptors (e.g epinephrine)
Physiologic antagonist
Sublingual administration is useful for
Drugs with high first pass metabolism
Which is the most informative name of a drug about the major ingredient?
Approved name
Which effect facilitates the oral bioavailability of medicinal products?
Rapid dissolution from the formulation
According to the Misuse of Drug Regulations (UK) this drug is schedule 3:
Pentobarbitone
The maximal activity specific to a drug
Intrinsic activity
Records should be made within 48 hours of the transaction and kept for a period of at least 5 years
Records on food producing animal treatments
Which technology is appropriate for achieving a pulsatile release of an active substance in a bolus?
Chip controlled diaphragms
Solid, single dose or multidose preparation for oral administration containing dry aggregates of powder particles
Granules
What is the proportion of ionized vs non-ionized molecules of a weak basic drig (pKa=7.4) in the stomach (pH=3.4)?
10,000:1
What “veterinary medicines regulation 2013” category can be supplied by pharmacists without prescription?
NFA-VPS
AVM-GSL
This is the name given to a drug by the manufacturers that produce the drug:
Proprietary name
Most appropriate method for the extraction of water soluble, heat sensitive substances from medicinal herbs
Extraction with ether
Which process can move drugs against a concentration gradient?
Active transport
Two drugs have been examined in animal studies, both have a therapeutic index of 2. It can be assumed that:
The dose response curves will be parallel
None of these
When given in ED50 doses, the 2 drugs are equally safe
When given at ED50 doses, no animals will be killed by the drugs
None of these