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Pharmac Flashcards

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0
Q

Ccr5 inhibitor

A

Maraviroc

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1
Q

Gp41 inhibitor

A

Enfuvirtide

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2
Q

Non nucleoside reverse transcriptase inhibitor

A

Efavirenz

Nevirepine

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3
Q

Nucleotide reverse transcriptase inhibitor

A

Tenofovir

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4
Q

Nucleoside reverse transcriptase inhibitor

A

Zidovudine
Didanosine
Stavudine
Abacavir

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5
Q

Integrase inhibitor

A

Raltegravir

Elvitagravir

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6
Q

Protease inhibitor

A

Saquinavir
Ritonavir
Indinavir

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7
Q

Alkylating agents - nitrogen mustards

A 
Mechlorethamine
Melphalan
Chlorambucil
Cyclophosphamide
Ifosamide
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8
Q

Alkylating agents - nitrosoureas

A

Carmustine

Lomustine

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9
Q

Alkylating agents ethylene amine

A

Thio TEPA

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10
Q

Alkylating agents alkyl sulfonates

A

Busulfan

Adv effect pulmonary fibrosis

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11
Q

Adv effect of cyclophosphamide

A

Causes hemorrhagic cystitis

Treat with mesna

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12
Q

Platinum containing analogues

A

Cisplatin

Carboplatin

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13
Q

Antimetabolites

A

Folate antagonists - a) methotrexate pemetrexed
Purine antagonists a) 6 mercaptopurine b) 6 thioguanine , axathioprim , fludarabine
Pyramidine antagonists - 5 flourouracil , gemsitabine , cytarabine

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14
Q

Microtubule damaging drugs

A

Vinka alkaloids Prevents microtu ule formation vinblastin , vincristine

Taxanes - preventa depolymerisation of microtubule palcitaxel , docetaxel

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15
Q

Topoisomerase 1 inhibitor

A

Topotecan , irinotecan

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16
Q

Topoisomerase 2 inhibitor

A

Etoposide

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17
Q

Alkylating agents - triazines

A

Dacarbazine

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18
Q

Adv effects of terracyclines

A

KAPIL DEV
Kidney disease, antiandrogenic actions,photosensitivity,diabetes insipidus , liver toxicity , dentition stains , expired drugs cause fanconis syndrome , vestibular toxicity(max with minocycline)

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19
Q

Drugs excreted through kidney

A

BOAST

Beta lactam antibiotics, wuinolones , aminoglycosides , amphotericin b , sulfonamides , tetracycline except doxy

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20
Q

Drugs excreted thru bile

A

METABOLISM Can Prevent Dose Adjustment In Renal Diseases -
Metronidazole , erythromycin , ceftriaxone , azithromycin , novobiocin , linezolid , isoniazid , stretogramins , moxyfloxacin, clindamycin , cefoperazone, doxy, ampicillin , nafcillin, rifampin , chloramphenicol

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21
Q

Drugs causing constipation

A

Very Much Tough

Verapamil , MAO inhibitors , tricyclic anti depressants , frusemide

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22
Q

Antidiabetic - glp analogues

Study These Flashcards
A

Exenatide

Livaglutide given parenteral

23
Q

Antidiabetic parenteral - amyline derivatives

24
Drugs following zero order kinetics
Zero WATT Power | Warfarin , alcohol, aspirin, theophylling , tolbutamide , phenytoin
25
Phase one reactions
ORH | Oxidation reduction hydrolysis cyclization decyclization
26
Phase 2 ( also called synthetic)
Glucuronide conjugation acetylation methylation sulfonation
27
Enzyme inducers
GPRS Cell Phone | Gresiofulvin phenytoin. Rifampin. Smoking. Carbamazepine. Phenobarbitone
28
Enzyme inhibitors
VIT K Cannot Cause Enzyme Inhibition | Valproate. Ketoconazole cimetenide ciprofloxacin. Erythromycin. INH.
29
Anticoagulants parenteral
Directly acting thrombin inhibitors - hirudin lepirudin Indirectly acting - heparin . Low molecular weight heparin. Fondaparinux. Idriaparinux( these two act agaisnt factor 10 a)
30
Oral anticoagulants
Vit k inhibitors - warfarin. Dicumarol. Phenindione Factor 10a inhibitors - rivaroxaban. Apixaban Direct thrombin inhibitor - dabigatranetexilate
31
Adv effects of amiodarone
The Periphery of My Lung Liver Cornea is Photosensitive Thyroid. Peripheral neuropathy. Myocardial depression. Lung fibrosis. Liver toxicity. Corneal microdeposits. Photosensitivity
32
Longest acting ocular beta blocker
Betaxolol
33
Weak acids
``` Barbiturates NSAIDS methotrexate Sulfonamides Pencillins ```
34
Weak bases
``` Morphine Atropine Amphetamines Quinines Hyoscine ```
35
Drugs with high first pass metabolism
Nitrates Have Large Pre Systemic Metabolism | Nitrates. Hydrocortisone. Lignocaine. Propranalol. Salbutamol. Morphine
36
Drugs with high plasma protein bindin
Bnzodiazepines. Chlorpropamide. Tolbutamide. Cyclosporine. Fluoxetine. Imipramine. Verspamil. Warfarin
37
Dialysis is not effective in
AVOIDD | Amphetamines. Verapamil. Op. Opoids. Imipramine. Digitalis. Diazepam
38
Drugs showin acetylation
SHIP | SULFONAMIDES. hydralazine. Isoniazid. Procainamide
39
Secondary messengers
Hydrophobic - DAG. IP3. Phosphotidlyinositol Hydrophilic- cAMP. cGMP GASES- NO. CO
40
Druga to be avoided in g6pd deficiency
``` Primaquine Quinine Chloroquine Sulfamethoxazole Nitrofurantoin ```
41
Drugs with high first pass metabolism
Nitrates Have Large Pre Systemic Metabolism | Nitrates. Hydrocortisone. Lignocaine. Propranalol. Salbutamol. Morphine
42
Drugs with high plasma protein bindin
Bnzodiazepines. Chlorpropamide. Tolbutamide. Cyclosporine. Fluoxetine. Imipramine. Verspamil. Warfarin
43
Dialysis is not effective in
AVOIDD | Amphetamines. Verapamil. Op. Opoids. Imipramine. Digitalis. Diazepam
44
Drugs showin acetylation
SHIP | SULFONAMIDES. hydralazine. Isoniazid. Procainamide
45
Secondary messengers
Hydrophobic - DAG. IP3. Phosphotidlyinositol Hydrophilic- cAMP. cGMP GASES- NO. CO
46
Druga to be avoided in g6pd deficiency
``` Primaquine Quinine Chloroquine Sulfamethoxazole Nitrofurantoin ```
47
Contraindications of digitalis
Contraindicated In Weak HEART | carditis. Increased calcium. WPW syndrome. Hypokalemia hypomagnesemia. Av block. Renal failure. Thyroid hypo n hyper
48
Alter cel wal permeability
Polymixins. Bacitracin. Amphotericin B
49
Inhibit cell wall synthesis
Pencillins. Cephalosporins. Vancomycin
50
Inhibit protein synthesis
ProTEC | tetracycline erythromycin. Chloramphenicol
51
Interfere with dna function
Rifampicin. Metronidazole
52
Misleadin of mrna
Aminoglycosides. Streptomycin
53
Interfere wih dna synthesis
Anti virals
54
Inhibit dna gyrase
Flourquinolones. Coprofloxacin
55
Drugs not to b given by IV
Paracetamol Diclofenac Choloquine Adrenaline

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