Pharmaceutics 3 Flashcards by Ayed 15

What’s types of coating equipments ?

The Standard coating pan
The perforated coating pan
The fluidized bed coated

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Definition of coating tablets

The application of coating composition to a moving bed of tablets with the concurrent use heated air to facilitate evaporation of the solvent

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What’s types of coating use to protect from gastric environment ?

Enteric coating acid resistance

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Mention standard coating pan modifications

The Pellegrini pan
The immersion sword
The immersion tube

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What’s the worst shape for coating tablets ?

Square flat- faced tablets

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True or false Q: tablets properties tablets must be rough to coated ?

False, should have smooth surface

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In tablets properties : what’s the best shape to coated tablets ?

Spherical shape

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In tablets properties : what’s the best shape to coated tablets ?

Spherical shape

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Why’s the sphere is best shape to coated tablets ?

Because 1) it’s allows tablets to rolls freely in the coating pan
And 2) have minimal contact

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Why is square flat-faced is the worst shape ?

Because in coating materials would collect btw the surface to glue them together
راح يتجمع مواد الطلاء بين الأسطح وتلتصق ببعض

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What’s diameter in standard coating pan ?

8 to 60 inches and rotated horizontal axis

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Types of application coating solution ?

Ladling and spray

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True or false
Ladling is a manual ?

True

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True or false
Spraying application is automatic?

True

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Advantage spraying over ladling ?

1) faster
2) more distributions

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Characteristics of the standard coating pan ?

1) inlet air supply and exhaust are separated
2) not immersed
3) open

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Character of immersion swords coating

1) closed
2) inlet and exhaust are one unit “ not separated “
3) perforated
4) immersed

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Characters of immersion tube ?

1) inlet and exhaust are separated
2) open
3) immersed
4) coating solution and heated are fused
5) rapid processing times

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Types of perforated coating pan system ?

1) Accela-Cota
2) Hi-coated

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Accela-Cola are totally perforated ? True or false

True

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Hi-coater are totally perforated? True or false

False
Partially perforated

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What’s the highest efficiency drying coating system?

Fluidized bed system

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Air capacity depends on

1) quantity of air flowing through the tablet bed
2) temperature of the air
3) the quantity of water the inlet air contains

Notes : increase temperatures will increase capacity to evaporate water or solvent

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Coating application depends on

1) spray rate
2) composition of the coating solution
3) droplets size produced ( pressure ,flow rate , viscosity)
4) tablets surface area
5) pan speed

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Increase of pressure will increase droplets size ? True or false

False Increase of pressure will decrease droplets size

Decrease of viscosity will decrease droplets size ? True or false

True

Increase flow rate will decrease droplets size ? True or false

True

In spraying process depends on skill of the coating operator ? True or false

False In ladling process depend on skill of the coating operator

Steps coating sugar in order ?

1) seal coating 2) subcoating 3) syrup 4) polishing

Seal coating must be hydrophilic ? True or false

False Hydrophobic not hydrophilic

In spraying do you need seal coating? Yes or no

No Just in ladling method

Why shellac coating length times to disintegration and dissolution times ?

Because of the polymerization of the shellac

Source of shellac ?

Is resin secreted by female lac bug on tree forest in India and Thailand

Source of Zein ?

Alcohol soluble protein derivation from corn

Role of subcoating ?

To build up the tablet size and increase Thickness

Steps in subcoating ?

2 steps 1) sticky binder solution 2) subcoating powder

In spray method you can mix both sticky binder and insoluble powder ? True or false

True

How many steps in syrup ? Mention steps

3 steps 1) glossy syrup 2) syrup containing color 3) clear coat in end

Machines using in polishing step ? Mention

1) clean standard coating 2) canvas lined polishing

film coating material must be stable in heat and moisture and light only ? True or false

False Must be stable in Moisture and air and light and heat Remember 4 conditions

Using enteric coated for

To be acid resistance and release in intestine

Non enteric coated role ?

To protect the tablet from light and moisture and oxidation and heat

Mention enteric coated examples

1) hydroxypropyl methylcellulose 2) methyl hydroxyethylcellulose 3) ethylcellulose 4) hydroxypropylcellulose 5) povidone 6) sodium carboxymethylcellulose 7) polyethylene glycol

Mention non enteric coated examples

1) hydroxypropyl methylcellulose 2) methyl hydroxyethylcellulose 3) ethylcellulose 4) hydroxypropylcellulose 5) povidone 6) sodium carboxymethylcellulose 7) polyethylene glycol

HPMC high flexibility when use it alone ? True or false

False High flexibility when using plasticiser

HMPC have different viscosity grades ? True or false

True

HMPC no interference with disintegration ? True or false

True and bioavailability

HMPC insoluble in GIF but soluble in organic and aqueous solvent ? True or false

False Soluble in GIF and organic and aqueous solvents

High flexibility mean no filling and no bridges? True or false

True

How to improve flexibility ?

Add plasticizer

What the percentage use mix btw HMPC and ethylcellulose to get fast sustained release ?

75% HMPC + 25% ETHYLcellulose

What the percentage use mix btw HPMC and ethylcellulose to get slow sustained release ?

50% HPMC + 50% ethylcellulose

Mix ethylcellulose with coating have water soluble to improve disintegration? True or false

True

ethylcellulose alone have high disintegration rate ? True or false

False No disintegration rate

Ethylcellulose unstable in most environments conditions? True or false

False Stable

Hydroxypropylcellulose can use it as subcoating in sugar coated ? True or false

True

Hydroxypropylcellulose can use it as subcoating in sugar coated ? True or false

True

Disadvantages of hydroxypropylcellulose is an extremely tacky ? True or false

True

How solve tracky in povidone coated ?

Use 1) plasticizer 2) suspended powder 3) other polymers

Use povidone to improve dispersion of colorant ? True or false

True

Film coating material ideal must be ease to printing on low speed ? True or false

False High speed not low speed that take time

Sodium carboxymethylcellulose insoluble in few organic solvents ? True or false

False Most not few

Polyethylene glycol coating is soft film? True or false

Falseee Hard film

Polyethylene glycol is resistant to elevated temp ? True or false

False Sensitive to elevated temp

Mention reasons to choose enteric coating ?

- to protect acid labile drugs - to prevent gastric distress or nausea due to irritation from drugs - to deliver drug intended for local action in the intestine “ local action “ - to deliver drug that are optimally absorbed in the small intestine to their primary absorption site on their most concentration form - to provide a delayed release component for repeat action tablets

Is design enteric coated for drugs have absorption window ? True or false

True Maximum absorption in intestine

We can use enteric coated for immediate releases ? Yes or no

No For delay and repeated action release

Enteric must be permeable to intestine coated ? True or false

True

No matter if enteric coated is changing stability I aging ? True or false

False Must be stable on aging for changing

Mention enteric film former?

1 cellulose acetate phthalate 2 acrylate polymers 3 hydroxypropyl methylcellulose phthalate 4 polyvinyl acetate phthalate

Cellulose acetate phthalate dissolves only below pH 6 . True or false

False Only above pH 6

Mention disadvantages of cellulose acetate phthalate

Hygroscopic Permeable to moisture Susceptible to hydrolytic Brittle

Phthalic and acetic acid is stable in aqueous media . True or false

False Unstable

How can you solve hygroscopic in CAP ( Cellulose acetate phthalate)

Combined with hydrophobic film forming materials to achieve a better enteric film

Acetylate polymers is a copolymers. True or false

True

Anionic Eudragit S soluble at pH 8?. True or false

True

Choose of plasticizer depend on :

Viscosity Tackiness Solubility Taste Compatibility Stability of the film and the product

Pharmaceutics 3 Flashcards

(77 cards)