Pharmacogenomics-Lecture 17

Question 1

Define Pharmacogenomics

Answer 1

The study of the role of inheritance in variation in drug response.
Important b/c: adverse drug run are a major cause of morbidity and mortality

Question 2

Name 3 types of genetic variation that influence pharmcotherapy

Answer 2

1) variation in proteins in drug metabolism or transport (pharmacokinetic)
2) variation in drug targets (pharmacodynamic)
3) variation in proteins associated with idiosyncratic adverse drug effects

Question 3

Butyrylcholinesterase Polymorphism

Answer 3

Defect in BCHE gene–> decreased rate of metabolism of succinylcholine (prolonged paralysis)
Condition transmitted as AR trait