Pharmacokinetics Flashcards

(43 cards)

1
Q

Best TCA for in the elderly

A

Lofepramine

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2
Q

What is the protein binding ratio of diazepam?

A

30-40%

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3
Q

What other name does meperidine go by

A

Pethidine

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4
Q

What is the half life of fluoxetine

A

2-3 days

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5
Q

Half life of norfluoxetine

A

2 weeks

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6
Q

Balanced hydrophobic and hydrophilic properties are essential for what quality in a drug

A

High permeability

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7
Q

Zaleplon half life

A

1 hour

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8
Q

Which antipsychotic will be most affected by the air

A

Sodium valproate

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9
Q

Half life of quetiapine

A

7 hours

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10
Q

Buspirone causes severe withdrawal effects, true or false

A

FALSE - causes none

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11
Q

What is the basis of clozapine induced hypersalivation?

A

Muscarinic M4 agonism

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12
Q

Poor response to lithium maintenance treatment is predicted by

A

Rapid cycling

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13
Q

Receptor blockade in which pathway leads to increased prolactin levels

A

Tuberoinfundibular

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14
Q

Weight gain caused by clozapine is due to

A

5Ht2c antagonism

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15
Q

Which antidementia drug acts directly on nicotine receptors

A

Galantamine

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16
Q

Mechanism of action of valproate

A

Inhibits catabolism of GABA
Reduces turnover of arachidonic acid
Activates EC signal related kinase pathway and thereby alters synaptic plasticity
Interfers with IC signalling
Promotes BDNTF expression
Reduces levels of protein kinase C

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17
Q

Buspirone acts on

A

5HT1a receptor

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18
Q

What % patients develop tardive dyskinesia every year of typical antipsychotics?

19
Q

Is moclobemide reversible or irreversible

20
Q

Carbamazepine, SJW, phenytoin and topiramate are inducers of what

21
Q

What do gabapentin, sulpride, amisulpride and lithium have in common

A

Little to no hepatic metabolism

22
Q

What is the active component of SJW

23
Q

In a patient with severe liver disease, the antipsychotic of choice is

24
Q

The SSRI most selective for serotonin reuptake is

25
Active metabolite of imipramine
Desipramine
26
Urinary acidification can help with OD of what
Amphetamines
27
Urinary alkalisation can help with OD of what
Salicylates
28
Effect of smoking on TCAs
Facilitates metabolism, lowers levels 25-50%
29
Effect of TCAs on their own absorption
May reduce own absorption (anticholinergic effects)
30
TCA plasma protein binding
Extensive
31
Which drug induces its own metabolism and reduces its plasma levels after 2 weeks at the same dose
Carbamazapine
32
Effect of fluvoxamine on theophylline
Increases levels by inhibiting CYP1A2
33
Clonidine and guanfacine act on which receptors
Presynaptic alpha 2 (agonists)
34
Paroxetine autoinhibits via what
CYP 450 2D6
35
When plotting plasma conc against time, AUC after a single dose shows
Bioavailability
36
There is poor absorption of antipsychotics in which part of the GI tract
Stomach
37
What is venlafaxine metabolised to
O desmethylvenlafaxine
38
Half life of aripiprazole
75 hours
39
Which treatment for mania can be commenced with a rapid loading dose?
Valproate
40
How many weeks are needed between fluoxetine and phenelzine?
5-6
41
The enhancement of drug effects following repeated administration of the same dose is called
Sensitisation
42
Which benzos skip phase 1 reactions and go straight through phase 2 metabolism?
Lorazepam, oxazepam and temazepam
43
Protein binding reactions become relevant in which condition?
Renal disease