Pharmacokinetics

Question 1

Propofol:

1) Elimination Half Time
2) Context Sensitive Half Time

Answer 1

1) Elimination Half Time: 0.5-1.5 hours

2) Context Sensitive Half Time: 40 min
(8 hr infusion)

Question 2

Etomidate Fx on SBP:
HR:

Answer 2

SBP: No change or Decreased
HR: No Change

Question 3

Propofol Fx on
SBP:
HR:

Answer 3

SBP: Decreased
HR: Decreased

Question 4

Ketamine Fx on
SBP:
HR:

Answer 4

SBP: Increased
HR: Increased

Question 5

Propofol induction dose for elderly

Answer 5

25-50% less than normal dose (normal: 1.5-2.5 mg/kg IV)

Question 6

Infusions of what dose cause Propofol Infusion Syndrome (Lactic Acidosis)?

Answer 6

> 75
mCG/kg/minute
for >24 hrs

Question 7

Ketamine:
Onset:
DOA:
E 1/2 t:

Answer 7

Onset: 1 min.
DOA: 10-20 min.
60-90 min return to full orientation
E 1/2 t: 2-3 hrs.

Question 8

Higher Vd with Highly Fat-Soluble drugs (like BZDs) causes what 3 effects?

Answer 8

Longer 1/2 Life (delayed clearance)
=> Longer Duration of Action
(stored in fat and Redistributed slowly)

Question 9

Higher Vd => what 2 effects?

Answer 9

Increase Half Life and Decreased Rate of Elimination