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Flashcards in Pharmacokinetics Deck (27):
1

Metoclopramide

Absorption: Enhances gastric emptying rate

2

Antacids

Absorption: affects absorption of drugs requiring gastric fluid acidity for dissolution, forms unabsorbable complexes with drugs in gastrointestinal tract

3

Proton pump inhibitors

Absorption: affects absorption of drugs requiring gastric fluid acidity for dissolution

4

Cholestyramine

Absorption: adsorbs drugs in gastrointestinal tract

5

Iron

Absorption: forms unabsorbable complexes with drugs in gastrointestinal tract

6

Thiopental

Distribution: anesthetic inducing agent, rapid distribution to brain (seconds)

7

Theophylline

Metabolism: substrate of CYP1A2

8

Warfarin

Metabolism: substrate of CYP2C9. Completely bound by plans plasma proteins and had GFR = 0

9

Cigarette smoke

Metabolism: inducer of CYP1A2

10

Carbamazepine

Metabolism: Inducer of CYPs 2C9, 2C19, 3A4

11

Phenobarbital

Metabolism: Inducer of CYPs 2C9, 2C19, 3A4

12

Phenytoin

Metabolism: Inducer of CYPs 2C9, 2C19, 3A4, example of saturable kinetics of elimination

13

Rifampin

Metabolism: Inducer of CYPs 2C9, 2C19, 3A4

14

St. John’s Wort

Metabolism: Inducer of CYPs 2C9, 2C19, 3A4

15

Ethanol

Metabolism: Inducer of CYP2E1

16

Azole antifungals

Metabolism: Inhibitors of CYP2C9 and CYP3A4

17

Macrolide antibacterials

Metabolism: Inhibitors of CYP3A4

18

HIV protease inhibitors

Metabolism: Inhibitors of CYP3A4

19

Grapefruit juice

Metabolism: Inhibitors of CYP3A4 (intestinal form only)

20

Cimetidine

Metabolism: broad spectrum inhibitor of many CYP450

21

Ammonium chloride

Excretion: used to acidify urine and increase excretion of weak base drugs

22

Sodium bicarbonate

Excretion: used to alkalinize urine and increase excretion of weak acid drugs

23

Probenecid

Excretion: weak acid inhibitor of tubular secretion of weak acids by OATs

24

Cimetidine

Excretion: weak base inhibitor of tubular secretion of weak bases by OCTs

25

Penicillin

Excretion: weak acid drug eliminated primarily by renal tubular secretion

26

Creatinine

Excretion: used to estimate GFR

27

p-Aminohippuric acid

Excretion: used to estimate renal plasma flow