Pharmacokinetics Flashcards
(3 cards)
1
Q
Absorption
A
Unaltered
2
Q
Distribution
A
Reduced liver first-pass metabolism
Reduced lean body mass with inc in fat
Lipid soluble drugs (diazepam): GREATER volume of distribution with prolonged half-life
Water soluble drugs (digoxin, ETOH): REDUCED volume of distribution
Reduced protein binding as albumin falls in UNWELL ELDERLY with inc potential for free drug (warfarin)
3
Q
Clearance
A
Hepatic
- 10% reduction in hepatic blood flow/unit volume
Renal
- renal excretion reduced in parallel with reduced GFR and reduced tubular secretion
