Pharmacokinetics Flashcards
(34 cards)
What the body does tot he drug
Pharmacokinetics
Movement of a drug from the site of administration into the blood
Absorption
Once int he blood, the drug moves to various parts of the body
Distribution
The drug is converted to a form that is more readily eliminated
Biotransofmation (metabolism)
Metabolism or excretion of the drug from the body
Elimination
When does it change from pharmacokinetics to pharmacodynamics
Once it gets to the site of action
What is the most common type of route of administration
Oral
Convenient route, but slower and less complete than parenteral forms
Oral administration
What are orally administered drugs subject to
First pass effect
Blood from the GI tract passes through the liver before entering other organs; during this, some or nearly all of the drug can be metabolized to an inactive or less active derivative; as a result some drugs are useless when given orally
First pass effect
Parenteral
Goes around the GI tract
What is a parenteral type of administration
IV
Most common route of administration
Oral
What is the safest route of administration
Oral
What is the most economical route of administration
Oral
Where is he major sire of absoprtion after oral administration
Small intestines
What can absorption be affected by when taking it orally
Affected by stomach contents
This route of administration is given under the tongue and offers the same feature as the buccal route
Sublingual
This route is very fast and voids the 1st pass effect
Sublingual
Why is sublingual absorption so fast?
Vasculature of the mouth
Which is faster route of administration, subcuataneous or intramuscular
IM, there is more vasculature in muscle than in fat
Absoprtion from an ______ sire is often faster and mroe complete than with oral
Intramuscular
What is an advantage to IM route of administration other than fast absorption
Large volume may be given
This allows large volume doses but is slower
Subcutaneous
