Pharmacology

Question 1

POMP

Answer 1

P is purine thiol (mercaptopurine), O is oncovin (vincristine), M is methotrexate and P is prednisolone

Question 2

Which of the following anticancer agent produces crystalluria?

Answer 2

Methotrexate

Methotrexate is an antimetabolite that inhibits DHFR is weakly acidic and forms crystals in urine. Frequent hydration and alkanization of urine can control crystalluria.

Question 3

Anticancer that inhibit Thymidylate synthethases

Answer 3

5-fluorouracil

inhibits thymidylate synthetase enzyme thereby inhibits the conversion of deoxy uridine monophosphate (dUMP) into deoxythymidine monophosphate (dTMP) leading to decreased synthesis of thymidine.

Question 4

CCS

Answer 4

Vinca alkaloids, taxanes, etoposide, Antimetabolites, Bleomycin

Vinca alkaloids, taxanes, etoposide (Etoposide and teniposide: late S-G2 phase) which act on M phase and Antimetabolites acting on S phase. Bleomycin (G2 phase), even acts by breakage of DNA strands, still cell cylce specific.

Question 5

CCNS

Answer 5

alkylating agents like carmustine, cyclophosphamide and cytotoxic antibiotics like dactinomycin and platinum compounds like cisplatin.

Question 6

MOA Vincristine VS Taxanes

Answer 6

Vincristine inhibits polymerization of free beta tubules into microtubules hence act as spindle poison.

Taxanes like paclitaxel and docetaxel does not inhibit formation of microtubules but cause their stabilization leading to inhibition of mitotic division.

Question 7

Less neurotoxic synthetic Vinca alkaloids

Answer 7

Vinorelbine

because bind specifically to mitotic tubulin rather than neural microtubules

Question 8

Drug that inhibit DNA polymerase

Answer 8

Cytarabine

Question 9

Name Anthracycline Abx

Answer 9

Daunorubicin
Epirubicin
Doxorubicin
IdarubicinN

Question 10

Antibiotic that act as alkylating agent

Antibiotic that effective in hypoxic tumor stem cell

Answer 10

Mitomycin a.k.a mitomycin-C

Question 11

Testicular Cancer can be treated with?

Answer 11

Vinblastine
Cisplatin
Bleomycin

Question 12

Name Top I and Top II inhibitor.

Answer 12

Top I - Etoposide, Teniposide

Top II - Irinotecan, Topotecan, Doxorubicin

Question 13

Anticancer for ALL (Acute Lymphoblastic leukemia).

Answer 13

Asparaginase

Mercaptopurine

Question 14

What are adverse effect of Asparaginase?

Answer 14

Allergic rxn (anaphylaxis)
Hyperglycemia
Pancreatitis
Mental depression
CNS thrombosis
Hyperalbuminemia
Hepatotoxicity (increase transaminase)
Coagulopathy

Question 15

Anticancer for choriocarcinoma?

Answer 15

MTX

Dactinomycin (gestational chorioCA)

Question 16

Can cause significant renal dysfunction and ototoxicity

Answer 16

Ciplastin

Question 17

Anticancer drug that is also used to treat psoriasis and rheumatoid arthritis:

Answer 17

Methotrexate

Question 18

Most common mechanism of resistance to both 6-MP (6-mercaptopurine) and 6-TG (6-thioguanine):
A- increased levels of dihydrofolate
reductase (DHFR)
B- increased drug efflux from the cells by
increased active transport
C- decreased HGPRT activity
D- decreased polyglutamate formation

Answer 18

C

Question 19

Major mechanism of action:polyfunctional alkylating agents
A- alkyl group transfer to mitotic proteins
B- interaction with carboxyl, sulfhydryl,
amino, hydroxyl, and phosphate groups
of non-nuclear cellular constituents
C- alkylation of DNA

Answer 19

C

Question 20

Less gastrointestinal and renal toxicity:
A- cisplatin
B- carboplatin

Answer 20

carboplatin

Question 21

Teniposide used in?

Monocytic leukemia
Testicular CA
Lung CA
Lymphoma

Answer 21

Lymphoma only, others is Etoposide

Question 22

This nitrogen mustard is clinically useful in managing chronic lymphocytic leukemia.
A- Cyclophosphamide (Cytoxan)
B- Chlorambucil (Leukeran)
C- Melphalan (Alkeran)

Answer 22

B