Pharmacology

Question 1

Entacapone

Answer 1

COMT Inhibitor

Inhibits conversion of Dopamine to 3-O-Methyldopa,
Increasing levodopa bioavailability and transport to brain
Extend the plasma half-life of dopamine
Prolong dopamine’s duration of action

Question 2

Pramipexole

Answer 2

Dopamine agonist at D2 and D3 receptors.

Question 3

Ropinirole

Answer 3

Dopamine agonist at D2 and D3 receptor

Question 4

Rasagiline

Answer 4

MAO-B Inhibitor

Question 5

Selegiline

Answer 5

MAO-B Inhibitor

Question 6

Selegiline

Answer 6

MAO-B Inhibitor

Question 7

Trihexyophenidyl

Answer 7

Anticholinergic

Primarily used for the treatment of tremors

Question 8

Amantadine

Answer 8

Anti-Glutaminergic: NMDA Antagonist

Increases presynaptic dopamine release
Inhibits re-uptake of synaptic dopamine

Mild-Moderate benefit for decreasing tremor.
Effective for Levodopa-induced dyskinesias.

Question 9

Younger patients with tremor-predominant PD

Answer 9

MAOB Inhibitors: Rasagiline
Antiglutaminergic: Amantadine
Anticholinergic: Trihexyphenidyl, Benztropine

Question 10

Best for younger patients whose predominant symptoms are resting tremor and hypersalivation

Answer 10

Trihexyphenidyl, Benztropine

Question 11

Dopamine Agonists

Answer 11

Bromocriptine (D2)
Pramipexole (D3/D4)
Ropinirole (D2)