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Pharmacology > Pharmacology > Flashcards

Pharmacology Flashcards

Learn the details of pharmacology

1
Q

Cytochrome P450 3A4

A

metabolizes steroids, Ca2+ channel blockers(nifedipine), Benzodiazepine,

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2
Q

Cytochrome p450 2D6

A

Activates Fluoxetine, metabolizes amitriptyline, ß-blockers (metoprolol), tricyclic antidepressants, dextromethorphan

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3
Q

Cytochrome P450 2C9

A

hexobarbital, ibuprofen, phenytoin, S-warfarin,

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4
Q

CYP 2C19 *2 mutants slow metabolizers

A

increased toxicity citalopram prolonged sedation diazepam increased sedation mephenytoin decreased saturation threshold for phenytoin decreased activity of proguanil decreased response to clopidogrel increased effectiveness of omeprazole against H. pylori

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5
Q

CYP 2C9 slow metabolizers

A

hypersensitive to s-warfarin phenytoin losarthan

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6
Q

CYP1A2*1F

A

Slow caffeine metabolizers increased risk for non-fatal MI

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Pharmacology (1 decks)

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